Patent US5725590A successfully refreshed from Google Patents.
Patent US5171755A successfully refreshed from Google Patents.
US5171755A
Expired / Lapsed
US
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Emulsions of highly fluorinated organic compounds
Assignee: Hemagen PFC LP
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Filing: 1988-04-29
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Granted: 1992-12-15
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Expires: 2008-04-29
Abstract
Abstract Improved emulsions of highly fluorinated organic compounds. The emulsions comprise a highly fluorinated organic compound, an oil, that is not substantially surface active and not significantly water soluble, and a surfactant. They are characterized by a well-defined relationship in the relative amounts of the three components.
Inventors
- 👤 Robert J. Kaufman
- 👤 Thomas J. Richard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:27
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
157 words
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 400 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 400 nm after 5 days in serum or ionic solutions, (3) an LD 50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 4° C.
Claim 2
Dependent Claim
157 words
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 400 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 400 nm after 5 days in serum or ionic solutions, (3) an LD 50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 4° C.
Claim 3
Dependent Claim
25 words
The emulsion according to claim 1, wherein the highly fluorinated organic compound is present in an amount between about 30% and about 55% by volume.
Claim 4
Dependent Claim
19 words
The emulsion according to claim 1, wherein the highly fluorinated organic compound is present in about 40% by volume.
Claim 5
Dependent Claim
28 words
The emulsion according to any one of claims 1, 2 or 3, wherein the highly fluorinated organic compound is selected from the group consisting of perfluorodecalin and perfluorooctylbromide.
Claim 6
Dependent Claim
21 words
The emulsion according to claim 1, wherein the oil is selected from the group consisting of safflower oil and soybean oil.
Claim 7
Dependent Claim
13 words
The emulsion according to claim 1, wherein the surfactant is egg yolk lecithin.
Claim 8
Dependent Claim
29 words
The emulsion according to claim 1, further comprising at least one compound selected from the group consisting of isotonic agents, osmotic pressure controlling agents, serum extending agents and antioxidants.
Claim 9
Dependent Claim
36 words
A red blood cell substitute comprising an amount of an emulsion according to any one of claims 1, 2, 4, 5, or 6, 7, said amount being therapeutically effective for oxygen transport and delivery in humans.
Claim 10
Dependent Claim
32 words
A composition for minimizing the adverse effects of coronary balloon angioplasty comprising a therapeutically effective amount of an emulsion according to any one of claims 1, 2, 4, 5, or 6, 7.
Claim 11
Dependent Claim
26 words
A composition for preserving organs comprising a preserving effective amount of an emulsion according to any one of claims 1, 2, 4, 5 or 6, 7.
Claim 12
Dependent Claim
31 words
A composition for treating heart attack, stroke and vascular occlusions comprising a therapeutically effective amount of an emulsion according to any one of claims 1, 2, 4, 5 or 6, 7.
Claim 13
Dependent Claim
31 words
A method for sustaining the oxygen requirements of a living organism comprising administering to the living organism in a therapeutically acceptable manner a red blood cell substitute according to claim 8.
Claim 14
Dependent Claim
27 words
A method for minimizing the adverse effects of coronary balloon angioplasty by perfusion of a composition according to claim 9 through the central lumen of the catheter.
Claim 15
Dependent Claim
14 words
A method for preserving organs by perfusion of a composition according to claim 10.
Claim 16
Dependent Claim
29 words
A method for treating heart attack, stroke and vascular occlusions comprising the step of administering to a patient in a therapeutically acceptable manner a composition according to claim 11.
Claim 17
Dependent Claim
157 words
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 300 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 300 nm after 5 days in serum or ionic solutions, (3) an LD 50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 25° C.
Claim 18
Dependent Claim
157 words
A physiologically acceptable emulsion comprising a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly water soluble, and a surfactant, wherein (a) the highly fluorinated organic compound is present in an amount between about 20% and about 60% by volume and (b) the amounts of the surfactant and oil are dependent on the volume percent of highly fluorinated organic compound and are present in amounts effective to produce emulsions characterized by (1) a particle size distribution of less than 300 nm after sterilization, (2) a serum stability characterized by a particle size distribution of less than 300 nm after 5 days in serum or ionic solutions, (3) an LD 50 in rats of at least 16 ml/kg of the highly fluorinated organic compound component of the emulsion, (4) an at least 70% survival upon total exchange in rats and (5) a shelf stability of at least several months at 25° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-15 | 1996-06-15 | 1996-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-15 | 2000-06-15 | 2000-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-15 | 2004-06-15 | 2004-12-15 | $7700.00 | Window Closed / Lapsed |