US4395393A
Expired / Lapsed
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Artificial blood emulsifiers
Assignee: BASF Corp
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Filing: 1981-08-10
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Granted: 1983-07-26
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Expires: 2001-08-10
Abstract
Abstract An artificial blood composition comprises a perfluoro chemical, physiological saline and a polyoxybutylene-polyoxyethylene block copolymer. The block copolymer provides stable emulsions.
Inventors
- 👤 Irving R. Schmolka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
164 words
An artificial blood comprising from 10 to 40 percent by weight of a perfluoro chemical, from 40 to 80 percent by weight physiological saline and from 2 to 8 percent by weight of a polyoxybutylene-polyoxyethylene block copolymer emulsifier, said emulsifier being a cogeneric mixture of conjugated polyoxybutylene-polyoxyethylene compounds containing in their structure oxybutylene groups, oxyethylene groups and an organic radical derived from a water-soluble organic compound containing a plurality of reactive hydrogen atoms and 2 to 12 carbon atoms; the compounds being characterized in that all of the oxybutylene groups are present in polyoxybutylene chains that are attached to the organic radical at the site of a reactive hydrogen atom thereby constituting a polyoxybutylene polymer; the oxyethylene groups being attached to the polyoxybutylene polymer in polyoxyethylene chains; the average molecular weight of the polyoxybutylene polymers in the mixture being between about 1200 and 3000, as determined by hydroxyl number, and the oxyethylene groups present constituting 60 to 85 percent by weight of the mixture.
Claim 2
Dependent Claim
164 words
An artificial blood comprising from 10 to 40 percent by weight of a perfluoro chemical, from 40 to 80 percent by weight physiological saline and from 2 to 8 percent by weight of a polyoxybutylene-polyoxyethylene block copolymer emulsifier, said emulsifier being a cogeneric mixture of conjugated polyoxybutylene-polyoxyethylene compounds containing in their structure oxybutylene groups, oxyethylene groups and an organic radical derived from a water-soluble organic compound containing a plurality of reactive hydrogen atoms and 2 to 12 carbon atoms; the compounds being characterized in that all of the oxybutylene groups are present in polyoxybutylene chains that are attached to the organic radical at the site of a reactive hydrogen atom thereby constituting a polyoxybutylene polymer; the oxyethylene groups being attached to the polyoxybutylene polymer in polyoxyethylene chains; the average molecular weight of the polyoxybutylene polymers in the mixture being between about 1200 and 3000, as determined by hydroxyl number, and the oxyethylene groups present constituting 60 to 85 percent by weight of the mixture.
Claim 3
Dependent Claim
25 words
The artificial blood of claim 1 wherein the perfluoro chemical is selected from the group consisting of perfluorodecalin, perfluoromethyldecalin, perfluorotributylamine, and perfluoro 2,2,4,4 tetramethyl pentane.
Claim 4
Dependent Claim
17 words
The artificial blood of claim 2 wherein the polyoxybutylene polymer has a molecular weight of about 1200.
Claim 5
Dependent Claim
17 words
The artificial blood of claim 2 wherein the polyoxybutylene polymer has a molecular weight of about 1800.
Claim 6
Dependent Claim
36 words
The artificial blood of claim 1 wherein the perfluoro chemical is perfluorodecalin and the polyoxybutylene polymer has a molcular weight of about 1200 and the oxyethylene content is about 80 percent by weight of the mixture.
Claim 7
Dependent Claim
37 words
The artificial blood of claim 1 wherein the perfluoro chemical is perfluorodecalin and the emulsifier polyoxybutylene polymer has a molecular weight of about 1800 and the oxyethylene content is about 80 percent by weight of the mixture.
References Cited (Backward Citations)
US4110474A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-25 | 1987-01-24 | 1987-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-25 | 1991-01-24 | 1991-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-25 | 1995-01-24 | 1995-07-26 | $7700.00 | Window Closed / Lapsed |