US4452818A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extraocular method of treating the eye with liquid perfluorocarbons
Assignee: Individual
•
Filing: 1982-03-19
•
Granted: 1984-06-05
•
Expires: 2002-03-19
Abstract
Abstract Extraocular ophthalmic preparations useful as therapeutic, lubricating or protective agents are disclosed. Liquid perfluorocarbons and substituted derivatives are the active components of the ophthalmic preparations. The neat perfluorocarbon liquids are not aqueous, wherefore, isotonicity and pH need not be considered in their preparation. Liquid sterility may be maintained without the addition of preservatives. Cornea and conjunctiva surfaces are provided with greater amounts of oxygen when the perfluorocarbon liquids are employed as eye drops.
Inventors
- 👤 Sterling J. Haidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/02; A61K31/025; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
57 words
A method for treating the eyes and providing lubrication and protection to the surface of the eye which comprises topically applying to the eye a composition comprising as an essential ingredient a transparent or light transmissive, stable, inert, viscous perfluorocarbon or substituted derivative thereof having oxygen carrying properties in an amount sufficient to act as a lubricant.
Claim 2
Independent Claim
57 words
A method for treating the eyes and providing lubrication and protection to the surface of the eye which comprises topically applying to the eye a composition comprising as an essential ingredient a transparent or light transmissive, stable, inert, viscous perfluorocarbon or substituted derivative thereof having oxygen carrying properties in an amount sufficient to act as a lubricant.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said liquid is a perfluorocyclocarbon.
Claim 4
Dependent Claim
29 words
The method of claim 2 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(mthylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.
Claim 5
Dependent Claim
10 words
The method of claim 1 wherein said perfluorocarbon is perfluoro-1-methyldecalin.
Claim 6
Dependent Claim
12 words
A method of claim 1 wherein said eye contains a contact lens.
Claim 7
Dependent Claim
22 words
A therapeutic method as defined in claim 1 wherein said composition is applied topically by instilling said composition into an eye cul-de-sac.
Claim 8
Dependent Claim
22 words
A therapeutic method as defined in claim 1 wherein said composition is dispersed across the corneal and conjunctiva surfaces of the eye.
Claim 9
Dependent Claim
22 words
A therapeutic method as defined in claim 1 wherein said composition also contains a pharmaceutical agent present in a therapeutically effective amount.
Claim 10
Dependent Claim
35 words
A therapeutic method as defined in claim 1 wherein said composition is in a form selected from the group consisting of a neat liquid, an emulsion, an ointment, a gel, a solution, and a suspension.
Claim 11
Dependent Claim
27 words
A therapeutic method as defined in claim 5 wherein said composition is dispersed to the corneal epithelium prior to inserting the contact lens onto the corneal epithelium.
Claim 12
Dependent Claim
31 words
A therapeutic method as defined in claim 5 wherein said composition has been applied to the contact lens after or before the contact lens has been inserted onto the corneal epithelium.
References Cited (Backward Citations)
US3911138A
Cited
US3911138B1
Cited
US4141973A
Cited
US4141973B1
Cited
US4105798A
Cited
US4110474A
Cited
US4187252A
Cited
US4366169A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-05 | 1987-12-05 | 1988-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-05 | 1991-12-05 | 1992-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-05 | 1995-12-05 | 1996-06-05 | $7700.00 | Window Closed / Lapsed |