Emulsification of fluorocarbon compounds for biological application as oxygen transporters

Claim 1

A method of preparing an aqueous oxygen-transporting emulsion suitable for injection into the bloodstream which comprises i. combining water with from about 5 to 35% by volume base on the water of a polyfluorinated carbon compound which is perfluorobutylamine, perfluorotributylamine, perfluorinated butyltetrahydrofuran, perfluorooctane, perfluoronaphthalane, perfluoromethylnaphthalene, 1,1,2-trihydroperfluoro-1-decane, 1,1,1,2,2-pentahydroperfluorodecane or a substance having the formula C.sub.p F.sub.2p.sub.+1 --CH=CH--C.sub.q F.sub.2q.sub.+1 wherein p and q are identical or different whole numbers from 2 to 10 and wherein their sum (p+q) is equal to or greater than 8; and a mixture of polyfluorinated surfactants whose total weight is from about 5 to 20% of the weight of the water, said mixture containing (1) predominantly hydrophilic surfactants (H) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 6 to 40, and (2) predominantly lipophilic surfactants (L) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub. 2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 1 to 5; the weight ratio of hydrophilic surfactants to lipophilic surfactants is from about 1/1 to 2.5/1, ii. heating said emulsifiable composition, with stirring, to at least about 70° C and iii. cooling the heated composition with continued stirring until a

Claim 2

A method of preparing an aqueous oxygen-transporting emulsion suitable for injection into the bloodstream which comprises i. combining water with from about 5 to 35% by volume base on the water of a polyfluorinated carbon compound which is perfluorobutylamine, perfluorotributylamine, perfluorinated butyltetrahydrofuran, perfluorooctane, perfluoronaphthalane, perfluoromethylnaphthalene, 1,1,2-trihydroperfluoro-1-decane, 1,1,1,2,2-pentahydroperfluorodecane or a substance having the formula C.sub.p F.sub.2p.sub.+1 --CH=CH--C.sub.q F.sub.2q.sub.+1 wherein p and q are identical or different whole numbers from 2 to 10 and wherein their sum (p+q) is equal to or greater than 8; and a mixture of polyfluorinated surfactants whose total weight is from about 5 to 20% of the weight of the water, said mixture containing (1) predominantly hydrophilic surfactants (H) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 6 to 40, and (2) predominantly lipophilic surfactants (L) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub. 2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 1 to 5; the weight ratio of hydrophilic surfactants to lipophilic surfactants is from about 1/1 to 2.5/1, ii. heating said emulsifiable composition, with stirring, to at least about 70° C and iii. cooling the heated composition with continued stirring until a

Claim 9

The method of promoting the transport of oxygen in the bloodstream which comprises injecting into said bloodstream an effective amount of an aqueous emulsion which contains water, from about 5 to 35% by volume of the water of a polyfluorinated carbon compound which is perfluorobutylamine, perfluorotributylamine, perfluorinated butyltetrahydrofuran, perfluorooctane, perfluronaphthalane, perfluoromethylnaphthalane, 1,1,2-trihydro-perfluoro-1-decane, 1,1,1,2,2-pentahydroperfluorodecane, or a substance having the formula: C.sub.p F.sub.2p.sub.+1 --CH=CH--C.sub.q F.sub.2q.sub.+1 wherein p and q are identical or different whole numbers from 2 to 10 and wherein their sum (p+q) is equal to or greater than 8, and a mixture of nonionic polyfluorinated surfactants whose total weight is from about 5 to 20% of the weight of the water, said mixture containing (1) predominantly hydrophilic surfactants (H) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 6 to 40, and (2) predominantly lipophilic surfactants (L) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4 and n is 1 to 5; the weight ratio of hydrophilic surfactants to lipophilic surfactants is from about 1/1 to 2.5/1.

Claim 10

The method of promoting the transport of oxygen in the bloodstream which comprises injecting into said bloodstream an effective amount of an aqueous emulsion which contains water, from about 5 to 35% by volume of the water of a polyfluorinated carbon compound which is perfluorobutylamine, perfluorotributylamine, perfluorinated butyltetrahydrofuran, perfluorooctane, perfluronaphthalane, perfluoromethylnaphthalane, 1,1,2-trihydro-perfluoro-1-decane, 1,1,1,2,2-pentahydroperfluorodecane, or a substance having the formula: C.sub.p F.sub.2p.sub.+1 --CH=CH--C.sub.q F.sub.2q.sub.+1 wherein p and q are identical or different whole numbers from 2 to 10 and wherein their sum (p+q) is equal to or greater than 8, and a mixture of nonionic polyfluorinated surfactants whose total weight is from about 5 to 20% of the weight of the water, said mixture containing (1) predominantly hydrophilic surfactants (H) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4, and n is 6 to 40, and (2) predominantly lipophilic surfactants (L) of the formula: C.sub.m F.sub.2m.sub.+1 --(CH.sub.2).sub.a --O(CH.sub.2 CH.sub.2 O).sub.n H wherein m is 4 to 10, C m F 2m +1 -- is linear or branched, a is 1 to 4 and n is 1 to 5; the weight ratio of hydrophilic surfactants to lipophilic surfactants is from about 1/1 to 2.5/1.