Patent US3161061A successfully refreshed from Google Patents.
US4105798A
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Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1977-08-22
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Granted: 1978-08-08
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Expires: 1997-08-22
Abstract
Abstract Novel emulsions of non-aromatizable perfluorinated compounds are useful as blood substitutes or as perfusion materials for the storage of organs such as kidneys prior to transplant. The compounds employed are polycyclic compounds and emulsions prepared from the perfluorinated derivatives thereof possess extremely high stability, zero or extremely low ultimate residue in the body, and a vapor pressure which is just about right for use in the body without adverse effects thereon.
Inventors
- 👤 Robert E. Moore
- 👤 Leland C. Clark, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K31/025; A61K31/035; C; C07; C07C; C07C17/00; C07C17/093; C07C17/10; C07C17/18; C07C17/26; C07C17/30; C07C23/00; C07C23/18; C07C23/20; C07C23/27; C07C23/28; C07C23/32; C07C23/38; C07C23/46; C07C2602/00; C07C2602/36; C07C2602/42
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
55 words
An artificial blood comprising an emulsion of a non-aromatizable perfluorinated material in water, the amount of water being greater than 40% by volume, said emulsion containing a non-toxic emulsifier and a perfluorinated C 9 -C 18 polycyclic hydrocarbon containing at least two bridgehead carbon atoms linked through a bridge containing at least one carbon atom.
Claim 2
Dependent Claim
55 words
An artificial blood comprising an emulsion of a non-aromatizable perfluorinated material in water, the amount of water being greater than 40% by volume, said emulsion containing a non-toxic emulsifier and a perfluorinated C 9 -C 18 polycyclic hydrocarbon containing at least two bridgehead carbon atoms linked through a bridge containing at least one carbon atom.
Claim 3
Dependent Claim
14 words
Composition according to claim 1 wherein the amount of said perfluorinated material is 10-30%.
Claim 4
Dependent Claim
13 words
Composition according to claim 1 wherein said perfluorinated material contains 9-12 carbon atoms.
Claim 5
Dependent Claim
13 words
Composition according to claim 1 wherein said perfluorinated material contains 10-11 carbon atoms.
Claim 6
Dependent Claim
17 words
Composition according to claim 1 additionally containing a yolk-phospholipid or poly(C 2 -C 3 alkylene oxide) surfactant.
Claim 7
Dependent Claim
16 words
Composition according to claim 1 wherein said perfluorinated material has a boiling point of 125°-156° C.
Claim 8
Dependent Claim
12 words
Composition according to claim 1 stable for several months at room temperature.
Claim 9
Dependent Claim
23 words
Composition according to claim 1 wherein the particle size of the perfluorinated material in the emulsion is from about 0.001 to 10 microns.
Claim 10
Dependent Claim
19 words
The composition according to claim 8 wherein the particle size of the perfluorinated material is from about 0.05-0.5 microns.
Claim 11
Dependent Claim
21 words
The composition according to claim 9 wherein about 50 weight percent of the particles have diameters of from about 0.05-0.3 microns.
Claim 12
Dependent Claim
13 words
Composition according to claim 1 wherein said perfluorinated material is a perfluorinated bicyclononane.
Claim 13
Dependent Claim
13 words
Composition according to claim 1 wherein said perfluorinated material is a perfluorinated bicyclooctane.
Claim 14
Dependent Claim
14 words
Composition according to claim 1 wherein said perfluorinated material is a perfluorinated adamantane hydrocarbon.
Claim 15
Dependent Claim
16 words
Composition according to claim 1 wherein the perfluorinated material is a mixture comprising perfluoromethyladamantane and perfluorodimethylbicyclo[3.3.1]nonane.
Claim 16
Dependent Claim
17 words
Composition according to claim 1 wherein the perfluorinated material is a mixture comprising perfluorodimethyladamantane and perfluorotrimethylbicyclo [3.3.1]nonane.
Claim 17
Dependent Claim
18 words
Composition according to claim 1 wherein the perfluorinated material is a mixture comprising perfluorotetrahydrodicyctopentadiene and perfluorobicyclo [5.3.0 decane.
Claim 18
Dependent Claim
23 words
Composition according to claim 1 additionally containing 10-100 cc O 2 (25° C, 760 mm Hg) per 100 cc of the perfluorinated material.
Claim 19
Dependent Claim
11 words
Composition according to claim 17 wherein said perfluorinated material is perfluorotetrahydrodicyclopentadiene.
Claim 20
Dependent Claim
13 words
Composition according to claim 17 wherein said perfluorinated material is a perfluorinated bicyclononane.
Claim 21
Dependent Claim
13 words
Composition according to claim 17 wherein said perfluorinated material is a perfluorinated bicyclooctane.
Claim 22
Dependent Claim
14 words
Composition according to claim 17 wherein said perfluorinated material is a perfluorinated adamantane hydrocarbon.
Claim 23
Dependent Claim
18 words
Composition according to claim 17 wherein the perfluorinated material is a mixture comprising perfluoromethyladamantane and perfluorodimethylbicyclo [3.3.1] nonane.
Claim 24
Dependent Claim
18 words
Composition according to claim 17 wherein the perfluorinated material is a mixture comprising perfluorodimethyladamantane and perfluorotrimethylbicyclo [3.3.1] nonane.
Claim 25
Dependent Claim
18 words
Composition according to claim 17 wherein the perfluorinated material is a mixture comprising perfluorotetrahydrodicyclopentadiene and perfluorobicyclo [5.3.0] decane.
Claim 26
Dependent Claim
24 words
A method for supporting oxygen-carbon dioxide transport in an animal body which comprises the intravascular administration of an artificial blood defined in claim 1.
Claim 27
Dependent Claim
55 words
A method for supporting oxygen transfer in an animal organ which comprises externally perfusing the animal organ with an artificial blood defined in claim 1 having oxygen dissolved therein, the perfluorinated material in said blood having a vapor pressure which permits it to leave the organ without causing adverse gas collection in the organ tissue.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-07 | 1982-02-06 | 1982-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-07 | 1986-02-06 | 1986-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-07 | 1990-02-06 | 1990-08-08 | $7700.00 | Window Closed / Lapsed |