US3993581A
Expired / Lapsed
US
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Process for preparing stable oxygen transferable emulsion
Assignee: Tanabe Pharma Corp
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Filing: 1974-07-02
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Granted: 1976-11-23
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Expires: 1994-07-02
Abstract
Abstract Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C3-5-alkylcyclohexanes), perfluoro(C4-6-alkyl tetrahydropyrans), perfluoro(C5-7-alkyltetrahydrofurans), perfluoro(C5-7-alkylmorpholins) and perfluoro(C9-11-trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 mu . It is usable as a blood substitute or a perfurate for preservation of the internal organs.
Inventors
- 👤 Kazumasa Yokoyama
- 👤 Koichi Yamanouchi
- 👤 Ryoichiro Murashima
- 👤 Ryozo Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; Y; Y10; Y10S; Y10S516/00; Y10S516/01; Y10S516/06
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
199 words
A process for preparing a stable emulsion in a physiologically acceptable aqueous medium, of an oxygen-transferable saturated aliphatic perfluorocarbon compound having 9 to 11 carbon atoms and a particle size of about 0.05 to about 0.3 μ, the perfluorocarbon compound having a boiling point ranging from about 140° to about 160° C. and having at least one alicyclic ring, heterocyclic ring, nitrogen atom or oxygen atom, consisting essentially of homogeneously mixing a phospholipid of 2 to 6% (W/V) as emulsifier, at least one fatty acid compound of 0.001 to 0.1% (W/V) as emulsifying adjuvant selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof, and said perfluorocarbon compound of 10 to 40% (W/V) in said physiologically acceptable aqueous medium to obtain a crude emulsion, and further emulsifying the crude emulsion by injecting it at a temperature of 45° to 55° C through a slit under a pressure of about 100 kg/cm 2 to 500 kg/cm 2 , thereby subjecting it to shearing force and mixing action based on a strong velocity gradient until the particle size of the perfluorocarbon compound in the resulting emulsion reaches 0.05 to 0.3 μ.
Claim 2
Dependent Claim
199 words
A process for preparing a stable emulsion in a physiologically acceptable aqueous medium, of an oxygen-transferable saturated aliphatic perfluorocarbon compound having 9 to 11 carbon atoms and a particle size of about 0.05 to about 0.3 μ, the perfluorocarbon compound having a boiling point ranging from about 140° to about 160° C. and having at least one alicyclic ring, heterocyclic ring, nitrogen atom or oxygen atom, consisting essentially of homogeneously mixing a phospholipid of 2 to 6% (W/V) as emulsifier, at least one fatty acid compound of 0.001 to 0.1% (W/V) as emulsifying adjuvant selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof, and said perfluorocarbon compound of 10 to 40% (W/V) in said physiologically acceptable aqueous medium to obtain a crude emulsion, and further emulsifying the crude emulsion by injecting it at a temperature of 45° to 55° C through a slit under a pressure of about 100 kg/cm 2 to 500 kg/cm 2 , thereby subjecting it to shearing force and mixing action based on a strong velocity gradient until the particle size of the perfluorocarbon compound in the resulting emulsion reaches 0.05 to 0.3 μ.
Claim 3
Dependent Claim
16 words
The process according to claim 1, wherein the perfluorocarbon compound is a perfluorocycloalkane or perfluoro (alkylcycloalkane).
Claim 4
Dependent Claim
14 words
The process according to claim 2, wherein the perfluorocycloalkane is perfluorodecalin or perfluoro (methyldecalin).
Claim 5
Dependent Claim
22 words
The process according to claim 2, wherein the perfluorocycloalkane is a perfluoro (butylcyclohexane), perfluoro (methylpropylcyclohexane), perfluoro (trimethylcyclohexane), perfluoro (ethylpropylcyclohexane) or perfluoro (pentylcyclohexane).
Claim 6
Dependent Claim
15 words
The process according to claim 1, wherein the perfluorocarbon compound is a perfluoro-saturated heterocyclic compound.
Claim 7
Dependent Claim
31 words
The process according to claim 5, wherein the perfluoro-saturated heterocyclic compound is perfluoro (butyltetrahydropyran), perfluoro (pentyltetrahydrofuran), perfluoro (hexyltetrahydrofuran), perfluoro (heptyltetrahydrofuran), perfluoro (N-hexylpiperidine), perfluoro (N-butylpiperidine), perfluoro (N-pentylmorpholine), perfluoro (N-hexylmorpholine) or perfluoro (N-heptylmorpholine).
Claim 8
Dependent Claim
16 words
The process according to claim 1, wherein the perfluorocarbon compound is a perfluoro-tert-amine or perfluoro (dioxa-alkane).
Claim 9
Dependent Claim
19 words
The process according to claim 7, wherein the perfluoro compound is a perfluoro (diethylhexylamine), perfluoro (dipropylbutylamine) or perfluoro (diethylcyclohexylamine).
Claim 10
Dependent Claim
27 words
The process according to claim 7, wherein the perfluoro compound is perfluoro (tetramethylene glycol diisobutyl ether), perfluoro (trimethylene glycol diisobutyl ether) or perfluoro (isopropylidene glycol di-n-propyl ether).
Claim 11
Dependent Claim
16 words
The process according to claim 1, wherein the physiologically acceptable aqueous medium is an isotonic solution.
Claim 12
Dependent Claim
17 words
The process according to claim 10, wherein the isotonic solution is 2.5% by weight aqueous glycerine solution.
Claim 13
Dependent Claim
35 words
The process according to claim 1, wherein the fatty acid compound is caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid or arachidonic acid.
Claim 14
Dependent Claim
49 words
The process according to claim 1 wherein the fatty acid compound is an alkali metal salt of a fatty acid selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
Claim 15
Dependent Claim
18 words
The process according to claim 13, wherein the alkali metal salt of the fatty acid is potassium palmitate.
Claim 16
Dependent Claim
18 words
The process according to claim 13, wherein the alkali metal salt of the fatty acid is sodium oleate.
Claim 17
Dependent Claim
47 words
The process according to claim 1, wherein the fatty acid compound is a monoglyceride of a fatty acid selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
Claim 18
Dependent Claim
16 words
The process according to claim 1, wherein the phospholipid is egg yolk phospholipid or soybean phospholipid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-23 | 1980-05-24 | 1980-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-23 | 1984-05-24 | 1984-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-23 | 1988-05-24 | 1988-11-23 | $7700.00 | Window Closed / Lapsed |