US4895876A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Concentrated stable fluorochemical aqueous emulsions containing triglycerides
Assignee: Versum Materials US LLC
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Filing: 1987-03-20
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Granted: 1990-01-23
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Expires: 2007-03-20
Abstract
Abstract A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include additional emulsifiers of SURFYNOL®SE surfactant and PLURONIC® P-105 surfactant. The emulsion is produced using an improved emulsification technique. The invention includes methods of oxygen transport in vascular systems wherein the oxygen carrying capacity of the vascular systems is improved with the emulsions of the present invention. Methods are also described for organ preservation extra-vivo by perfusing, suffusing, flushing and filling organs outside the body with the oxygen carrying emulsions of the present invention. Finally, methods of synthesis of the emulsions by emulsifying the components and aqueous medium using high shear mixing is also described.
Inventors
- 👤 Frank K. Schweighardt
- 👤 Charles R. Kayhart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/0012; A61K9/0019; A61K9/0026; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61P; A61P7/00; A61P7/08
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
48 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 60 weight/volume percent or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 2
Dependent Claim
48 words
A stable aqueous emulsion of a perfluorochemical comprising approximately 60 weight/volume percent or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 3
Dependent Claim
30 words
The emulsion of claim 1 wherein the perfluorochemical is selected from the group consisting of perfluoroalkylcyclohexane having 3 to 5 carbon atoms in the alkyl group, perfluorooctylbromide, perfluorodecalin and perfluoromethyldecalin.
Claim 4
Dependent Claim
10 words
The emulsion of claim 1 wherein the perfluorochemical is perfluorodecalin.
Claim 5
Dependent Claim
18 words
The emulsion of claim 1 wherein the perfluorochemical is present in the amount of approximately 75 weight/volume %.
Claim 6
Dependent Claim
12 words
The emulsion of claim 1 wherein the phospholipid is an egg phosphatide.
Claim 7
Dependent Claim
18 words
The emulsion of claim 1 wherein the phospholipid is present in a range of approximately 1-2 weight percent.
Claim 8
Dependent Claim
25 words
The emulsion of claim 1 wherein the triglyceride of fatty acids is selected from the group consisting of safflower oil, soybean oil and mixtures thereof.
Claim 9
Dependent Claim
23 words
The emulsion of claim 1 wherein the triglyceride of fatty acids is present in the range of approximately 10 to 20 weight %.
Claim 10
Dependent Claim
18 words
The emulsion of claim 1 wherein the triglyceride of fatty acids is present in approximately 20 weight %.
Claim 11
Dependent Claim
14 words
The emulsion of claim 1 including an additional emulsifier adjuvant of an acetylenic diol.
Claim 12
Dependent Claim
107 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorodecalin having essentially no detectable hydrogen or olefinic character and a mean particle size of about 0.15 microns which comprises said perfluorodecalin in a concentration of 60 to 90 weight/volume %, a phospholipid as an emulsifier in a concentration of approximately 1.2 weight %. at least one triglyceride of fatty acids as an emulsifier adjuvant in a concentration of 10 to 20 weight % wherein the fatty acids have 16 to 18 carbon atoms, and glycerin in an amount of approximately 2.5 weight %. said emulsion being suitable for use as a blood substitute.
Claim 13
Dependent Claim
107 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorodecalin having essentially no detectable hydrogen or olefinic character and a mean particle size of about 0.15 microns which comprises said perfluorodecalin in a concentration of 60 to 90 weight/volume %, a phospholipid as an emulsifier in a concentration of approximately 1.2 weight %. at least one triglyceride of fatty acids as an emulsifier adjuvant in a concentration of 10 to 20 weight % wherein the fatty acids have 16 to 18 carbon atoms, and glycerin in an amount of approximately 2.5 weight %. said emulsion being suitable for use as a blood substitute.
Claim 14
Dependent Claim
19 words
The emulsion of claim 11 including an additional emulsifier adjuvant of an acetylenic diol and a polyoxyethylene, polyoxypropylene copolymer.
Claim 15
Dependent Claim
9 words
The emulsion of claim 11 including an albumin component.
Claim 16
Independent Claim
103 words
A method of enhancing the oxygen carrying capacity of oxygen through the vascular system and into the tissue of mammals which comprises administering a volumetric amount of a perfluorochemical emulsion to said mammal sufficient to maintain the total vascular volume of said mammal and subjecting the respiratory function of the mammal to elevated concentrations of oxygen above atmospheric concentrations wherein said emulsion comprises approximately 60 weight/volume % or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 17
Independent Claim
103 words
A method of enhancing the oxygen carrying capacity of oxygen through the vascular system and into the tissue of mammals which comprises administering a volumetric amount of a perfluorochemical emulsion to said mammal sufficient to maintain the total vascular volume of said mammal and subjecting the respiratory function of the mammal to elevated concentrations of oxygen above atmospheric concentrations wherein said emulsion comprises approximately 60 weight/volume % or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 18
Independent Claim
60 words
A method of preserving internal organs outside the body which comprises perfusing the same with a preoxygenated perfluorochemical emulsion comprising approximately 60 weight/volume % or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 19
Independent Claim
60 words
A method of preserving internal organs outside the body which comprises perfusing the same with a preoxygenated perfluorochemical emulsion comprising approximately 60 weight/volume % or greater of a perfluorochemical, approximately 0.5 up to 7 weight % of a phospholipid which emulsifies said perfluorochemical, approximately 5-30 weight % of a triglyceride of fatty acids, and the remainder of an aqueous medium.
Claim 20
Independent Claim
92 words
The method for preparing a stable aqueous emulsion of a perfluorochemical in a perfluorochemical concentration range of approximately 60 wt/vol % or greater wherein an aqueous emulsifier is mixed with a first portion of the perfluorochemical volume maintaining a temperature below 35° C. to produce an initial perfluorochemical emulsion and thereafter mixing the remaining portion of the perfluorochemical volume to the initial perfluorochemical emulsion while maintaining a temperature below 35° C. to result in a final aqueous perfluorochemical emulsion having a perfluorochemical concentration in the range of 60 wt/vol % or greater.
Claim 21
Independent Claim
92 words
The method for preparing a stable aqueous emulsion of a perfluorochemical in a perfluorochemical concentration range of approximately 60 wt/vol % or greater wherein an aqueous emulsifier is mixed with a first portion of the perfluorochemical volume maintaining a temperature below 35° C. to produce an initial perfluorochemical emulsion and thereafter mixing the remaining portion of the perfluorochemical volume to the initial perfluorochemical emulsion while maintaining a temperature below 35° C. to result in a final aqueous perfluorochemical emulsion having a perfluorochemical concentration in the range of 60 wt/vol % or greater.
Claim 22
Dependent Claim
20 words
The method of claim 16 wherein the emulsion during mixing is maintained at a temperature no greater than 20° C.
Claim 23
Dependent Claim
13 words
The method of claim 16 wherein the mixing is a high shear mixing.
Claim 24
Dependent Claim
26 words
The method of claim 16 wherein the first portion of perfluorochemical mixed with the emulsifier is approximately half of the total perfluorochemical volume to be emulsified.
Claim 25
Dependent Claim
35 words
The method of claim 16 wherein the perfluorochemical is prepared by initial fluorination of a chemical in the presence of cobalt trifluoride and subsequent complete fluorination of said chemical in the presence of elemental fluorine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-22 | 1993-07-24 | 1994-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-22 | 1997-07-24 | 1998-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-22 | 2001-07-24 | 2002-01-23 | $7700.00 | Window Closed / Lapsed |