US3911138A
Expired / Lapsed
US
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Artificial blood and method for supporting oxygen transport in animals
Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER A NONPROFIT OHIO CORP
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Filing: 1973-02-26
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Granted: 1975-10-07
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Expires: 1993-02-26
Abstract
Abstract Perfluorocyclocarbons and emulsions containing emulsified particles of these perfluorocarbons are useful is supporting life as intravascular oxygen and carbon dioxide transport agents. Stable emulsions of perfluorocarbocyclic derivatives are prepared for use as artificial bloods and perfusates for organs. Intravenously infused emulsions containing perfluorocyclocarbons such as perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), and the like, serve as intravascular oxygen and carbon dioxide transport agents. Fluorocarbon liquids are also useful as an external respiration media for transporting oxygen-carbon dioxide necessary to support intravascular respiration. Perfluorocyclocarbons have been found after intravenous emulsion infusion as artificial bloods to collect in the reticuloendothelial system (RES) of the amimal body. However, it has also been found that perfluorocyclocarbon compounds leave the RES of the animal body and certain of these compounds, e.g., perfluoro(decahydronaphthalene), leave the RES at a much faster rate than others. Furthermore, after the intravenously infused perfluorocyclocarbon emulsions function as artificial bloods, the perfluorocyclocarbons have the capability of leaving the animal body through the tissue, e.g., the lungs and skin.
Inventors
- 👤 Jr Leland C Clark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:23
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K31/025; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/105831
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
67 words
AN ARTIFICIAL BLOOD COMPRISING AN AQUEOUS EMULSION CONTAINING EMULSIFIED PARTICLES HAVING A PARTICLE SIZE UP TO ABOUT 100 MICRONS OF A RES-PHOBIC PERFLUOROCYCLOCARBON AN EMULSIFYING AGENT IN A NON-TOXIC NON-HEMOLYTIC AMOUNT AND WATER, SAID PARTICLES CONTAINED IN AN AMOUNT SUFFICIENT TO SUPPORT AN OXYGEN CARRING FUNCTION SAID PERFLUOROCLYCLOCARBON HAVING A VAPOR PRESSURE WHICH PERMITS IT TO LEAVE THE RES WITHOUT CAUSING ADVERSE GAS COLLECTION IN ANIMAL TISSUE.
Claim 2
Dependent Claim
67 words
AN ARTIFICIAL BLOOD COMPRISING AN AQUEOUS EMULSION CONTAINING EMULSIFIED PARTICLES HAVING A PARTICLE SIZE UP TO ABOUT 100 MICRONS OF A RES-PHOBIC PERFLUOROCYCLOCARBON AN EMULSIFYING AGENT IN A NON-TOXIC NON-HEMOLYTIC AMOUNT AND WATER, SAID PARTICLES CONTAINED IN AN AMOUNT SUFFICIENT TO SUPPORT AN OXYGEN CARRING FUNCTION SAID PERFLUOROCLYCLOCARBON HAVING A VAPOR PRESSURE WHICH PERMITS IT TO LEAVE THE RES WITHOUT CAUSING ADVERSE GAS COLLECTION IN ANIMAL TISSUE.
Claim 3
Dependent Claim
29 words
The composition of claim 1 wherein said fluorocarbon is selected from the group consisting of perfluoro (methylcyclohexane), perfluoro (1,3-dimethylcyclohexane), perfluoro (decahydronaphthalene), perfluoro (decahydro-1-methylnaphthalene) and perfluoro (decahydrodimethylnaphthalene), or mixtures thereof.
Claim 4
Dependent Claim
25 words
The composition of claim 1 wherein said perfluorocyclocarbon has a vapor pressure of within the range of about 1 to about 50 torr at 37.5*C.
Claim 5
Dependent Claim
11 words
The composition of claim 1 wherein said perfluorocyclocarbon is perfluoro (decahydronaphthalene).
Claim 6
Dependent Claim
17 words
The composition of claim 1 whereiin said perfluorocyclocarbon comprises a mixture of perfluoro (decahydronaphthalene) and perfluoro (1,3-dimethylcyclohexane).
Claim 7
Dependent Claim
15 words
The composition of claim 2 wherein said emulsion contains an emulsifying agent comprising polyoxyethylene-polyoxypropylene copolymer.
Claim 8
Dependent Claim
20 words
The composition of claim 6 wherein said emulsion contains an ionic component in an amount to provide a non-hypertonic emulsion.
Claim 9
Dependent Claim
25 words
A method for supporting intravascular oxygen-carbon dioxide transport in an animal body which comprises the intravascular administration of an artificial blood defined in claim 1.
Claim 10
Dependent Claim
25 words
The method of claim 8 wherein said perfluorocyclocarbon has a vapor pressure of within the range of about 1 to about 50 torr at 37.5*C.
Claim 11
Dependent Claim
29 words
The method o claim 8 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro (methylcyclohexane), perfluoro (1,3-dimethylcyclohexane), perfluoro (decahydronaphthalene), perfluoro (decahydro-1-methylnaphthalene) and perfluoro (decahydrodimethylnaphthalene) or mixtures thereof.
Claim 12
Dependent Claim
22 words
The method of claim 8 further comprising the step of exposing the animal lungs to an outside environment comprising a perfluorocyclocarbon vapor.
Claim 13
Dependent Claim
21 words
The method of claim 11 wherein said intravascularly administerEd perfluorocyclocarbon has a vapor pressure greater than about 40-50 torr at 37.5*C.
Claim 14
Dependent Claim
24 words
The method of claim 8 wherein said perfluorocyclocarbon is present in a concentration of about 10 to about 30% by volume of said emulsion.
Claim 15
Dependent Claim
20 words
The method of claim 8 wherein said intravascularly administered perfluorocarbon escapes from the animal body by way of the tissue.
Claim 16
Dependent Claim
16 words
The method of claim 14 wherein the perfluorocarbon escapes as vapor excreted from the animal lungs.
Claim 17
Dependent Claim
17 words
The method of claim 14 wherein the perfluorocarbon escapes as a vapor excreted from the animal skin.
Claim 18
Dependent Claim
23 words
The composition of claim 1 wherein said particles have an average particle size within the range of about 0.001 to about 0.1 micron.
Claim 19
Independent Claim
54 words
A method for supporting respiration of an animal which comprises external exposure of the animal to a fluid external respiration medium consisting essentially of a liquid RES-phobic perfluorocyclocarbon having oxygen dissolved therein, said perfluorocyclocarbon having a vapor pressure which permits it to leave the RES without causing adverse gas collection in the animal tissue.
Claim 20
Independent Claim
54 words
A method for supporting respiration of an animal which comprises external exposure of the animal to a fluid external respiration medium consisting essentially of a liquid RES-phobic perfluorocyclocarbon having oxygen dissolved therein, said perfluorocyclocarbon having a vapor pressure which permits it to leave the RES without causing adverse gas collection in the animal tissue.
Claim 21
Independent Claim
48 words
A method for supporting oxygen transfer in an animal organ which comprises externally perfusing the animal organ with a liquid RES-phobic perfluorocyclocarbon having oxygen dissolved therein, said perfluorocyclocarbon having a vapor pressure which permits it to leave the organ without causing adverse gas collection in the organ tissue.
Claim 22
Independent Claim
48 words
A method for supporting oxygen transfer in an animal organ which comprises externally perfusing the animal organ with a liquid RES-phobic perfluorocyclocarbon having oxygen dissolved therein, said perfluorocyclocarbon having a vapor pressure which permits it to leave the organ without causing adverse gas collection in the organ tissue.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-10-06 | 1979-04-07 | 1979-10-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-10-06 | 1983-04-07 | 1983-10-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-10-06 | 1987-04-07 | 1987-10-07 | $7700.00 | Window Closed / Lapsed |