US6416549B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antithrombogenic annuloplasty ring having a biodegradable insert
Assignee: Corcym SRL
•
Filing: 1999-07-20
•
Granted: 2002-07-09
•
Expires: 2019-07-20
Abstract
Abstract This invention provides an antithrombogenic annuloplasty rings, and methods for making the same, wherein the annuloplasty rings have a desired degree of initial rigidity to facilitate ease of handling during implantation but which becomes flexible some time after implantation. The annuloplasty ring contains a relatively rigid insert enclosed by a fabric sheath, the insert being at least partly comprised of a biodegradable material. Following surgical implantation of the annuloplasty ring, the rigid insert component of the ring, upon exposure to blood and/or other physiological fluids, undergoes a controlled biodegradation which decreases its rigidity, thereby increasing the flexibility of the implanted annuloplasty ring. Furthermore, at least some portion of the annuloplasty ring has incorporated into or onto its structure one or more antithrombogenic agents or materials in a manner which reduces the likelihood of thrombosis following implantation.
Inventors
- 👤 Joseph A. Chinn
- 👤 R. Michael Casanova
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:38
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2442; A61F2/2445; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
62 words
An annuloplasty ring comprising: a ring insert at least partly comprised of a surface eroding biodegradable polymer material group consisting of polyanhydrides, polyvinylpyrolidone, and polyvinyl alcohol; an elastomeric sheath enclosing said ring insert; a fabric sheath enclosing said ring insert and said elastomeric sheath; and one or more antithrombogenic agents or materials incorporated into at least some portion of the annuloplasty ring.
Claim 2
Dependent Claim
62 words
An annuloplasty ring comprising: a ring insert at least partly comprised of a surface eroding biodegradable polymer material group consisting of polyanhydrides, polyvinylpyrolidone, and polyvinyl alcohol; an elastomeric sheath enclosing said ring insert; a fabric sheath enclosing said ring insert and said elastomeric sheath; and one or more antithrombogenic agents or materials incorporated into at least some portion of the annuloplasty ring.
Claim 3
Dependent Claim
59 words
The annuloplasty ring of claim 1 , wherein the antithrombogenic agents or materials are at least partly comprised of heparin, hirudin, albumin, phospholipids, streptokinase, tissue plasminogen activator (TPA), urokinase, hyaluronic acid, chitosan, methyl cellulose, poly(ethylene oxide), poly(vinyl pyrrolidone), endothclial cell growth factor, epithelial growth factor, osteoblast growth factor, fibroblast growth factor, platelet derived growth factor or angiogenic growth factor.
Claim 4
Dependent Claim
22 words
The annuloplasty ring of claim 1 , wherein the antithrombogenic agents or materials are covalently or ionically incorporated into the annuloplasty ring.
Claim 5
Dependent Claim
26 words
The annuloplasty ring of claim 1 , wherein the antithrombogenic agents or materials are ionically or covalently incorporated into the fabric sheath of the annuloplasty ring.
Claim 6
Dependent Claim
18 words
The annuloplasty ring of claim 1 , wherein the surface eroding biodegradable polymer material comprises a photopolymerizable polyanhydride.
Claim 7
Dependent Claim
22 words
The annuloplasty ring of claim 1 , wherein the surface eroding biodegradable polymer material comprises a polyanhydride polymerized from methacrylate anhydride monomers.
Claim 8
Dependent Claim
22 words
The annuloplasty ring of claim 6 , wherein the methacrylate anhydride monomers are synthesized from diacid molecules of sebacic acid or 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 9
Dependent Claim
31 words
The annuloplasty ring of claim 6 , wherein the surface eroding biodegradable polymer material comprises a a copolymer of methacrylate anhydride monomers synthesized from diacid molecules of sebacic acid and 1,6-bis(pcarboxyphenoxy)-hexane.
Claim 10
Dependent Claim
17 words
The annuloplasty ring of claim 1 , wherein the fabric sheath is comprised of a polymeric material.
Claim 11
Dependent Claim
28 words
The annuloplasty ring of claim 1 , wherein the fabric sheath is comprised of a polymeric material selected from the group consisting of polyethyleneterephthalate, polytetrafluoroethylene and polyester (polyacetate).
Claim 12
Dependent Claim
23 words
The annuloplasty ring of claim 1 , wherein the elastomeric sheath is comprised of a silicone rubber, a poly(ether urethane) or a polytetrafluoroethylene.
Claim 13
Dependent Claim
29 words
The annuloplasty ring of claim 1 , wherein the ring insert further comprises one or more plasticizers, stabilizers, pigments, dyes, radio-opaque materials, lubricants, antioxidants, bioactive agents or antimicrobial agents.
Claim 14
Independent Claim
81 words
A method for making an annuloplasty ring comprising: forming a ring insert at least partly comprised of a surface eroding biodegradable polymer material from the group consisting of polyanhydrides, polyvinylpyrolidone, and polyvinyl alcohol; enclosing at least a portion of said ring insert in an elastomeric sheath; enclosing at least a portion of said ring insert and said elastomeric sheath in a fabric sheath; and incorporating one or more antithrombogenic agents or materials into at least some portion of the annuloplasty ring.
Claim 15
Independent Claim
81 words
A method for making an annuloplasty ring comprising: forming a ring insert at least partly comprised of a surface eroding biodegradable polymer material from the group consisting of polyanhydrides, polyvinylpyrolidone, and polyvinyl alcohol; enclosing at least a portion of said ring insert in an elastomeric sheath; enclosing at least a portion of said ring insert and said elastomeric sheath in a fabric sheath; and incorporating one or more antithrombogenic agents or materials into at least some portion of the annuloplasty ring.
Claim 16
Dependent Claim
58 words
The method of claim 13 , wherein the antithrombogenic agents or materials are at least partly comprised of heparin, hirudin, albumin, phospholipids, streptokinase, tissue plasminogen activator (TPA), urokinase, hyaluronic acid, chitosan, methyl cellulose, poly(ethylene oxide), poly(vinyl pyrrolidone), endothclial cell growth factor, epithelial growth factor, osteoblast growth factor, fibroblast growth factor, platelet derived growth factor or angiogenic growth factor.
Claim 17
Dependent Claim
22 words
The method of claim 13 , wherein the antithrombogenic agents or materials are covalently or ionically incorporated into with the annuloplasty ring.
Claim 18
Dependent Claim
25 words
The method of claim 13 , wherein the antithrombogenic agents or materials are ionically or covalently incorporated into the fabric sheath of the annuloplasty ring.
Claim 19
Dependent Claim
23 words
The method of claim 13 , wherein the ring insert is formed by molding, extrusion or machining the surface eroding biodegradable polymer material.
Claim 20
Dependent Claim
17 words
The method of claim 13 , wherein the surface eroding biodegradable polymer material comprises a photopolymerizable polyanhydride.
Claim 21
Dependent Claim
21 words
The method of claim 13 , wherein the surface eroding biodegradable polymer material comprises a polyanhydride polymerized from methacrylate anhydride monomers.
Claim 22
Dependent Claim
21 words
The method of claim 19 , wherein the methacrylate anhydride monomers are synthesized from diacid molecules of sebacic acid or 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 23
Dependent Claim
29 words
The method of claim 19 , wherein the surface eroding biodegradable polymer material comprises a copolymer of methacrylate anhydride monomers synthesized from diacid molecules of sebacic acid and 1,6-bis(p-carboxyphenoxy)-hexane.
Claim 24
Dependent Claim
16 words
The method of claim 13 , wherein said fabric sheath is comprised of a polymeric material.
Claim 25
Dependent Claim
25 words
The method of claim 22 , wherein said fabric sheath comprises a polymeric material selected from the group consisting of polyethyleneterephthalate, polytetrafluoroethylene and polyester (polyacetate).
Claim 26
Dependent Claim
22 words
The method of claim 13 , wherein the elastomeric sheath is comprised of a silicone rubber, a poly(ether urethane) or a polyetrafluoroethylene.
Claim 27
Dependent Claim
28 words
The method of claim 13 , wherein the ring insert further comprises one or more plasticizers, stabilizers, pigments, dyes, radioopaque materials, lubricants, antioxidants, bioactive agents or antimicrobial agents.
References Cited (Backward Citations)
US3634123A
Cited
US3511684A
Cited
US3896813A
Cited
US3585647A
Cited
US3616935A
Cited
US3755218A
Cited
US3987797A
Cited
US4107121A
Cited
US4118485A
Cited
US4055861A
Cited
US4116898A
Cited
US4265927A
Cited
US4302368A
Cited
US4254180A
Cited
US4291133A
Cited
US4331697A
Cited
US4326532A
Cited
US4678671A
Cited
US4634762A
Cited
US4442133A
Cited
US5741551A
Cited
US4973493A
Cited
US5512329A
Cited
US4526714A
Cited
US4592920A
Cited
US4542169A
Cited
US4521564A
Cited
US4581028A
Cited
US4676974A
Cited
US4678660A
Cited
US4600652A
Cited
US4642242A
Cited
US4612337A
Cited
US4713402A
Cited
US4917686A
Cited
US4749585A
Cited
US4895566A
Cited
US5263992A
Cited
US4979959A
Cited
US4952149A
Cited
US4952419A
Cited
US5053453A
Cited
US5013306A
Cited
US5104407A
Cited
US5104407B1
Cited
US5103306A
Cited
US5217493A
Cited
US5492763A
Cited
US5414075A
Cited
US5688516A
Cited
US5308641A
Cited
US5624704A
Cited
US5865814A
Cited
US5679659A
Cited
US5877263A
Cited
US5716397A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-07-08 | 2006-01-07 | 2006-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-07-08 | 2010-01-07 | 2010-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-07-08 | 2014-01-07 | 2014-07-09 | $7700.00 | Window Closed / Lapsed |