US4331697A
Expired / Lapsed
US
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Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
Assignee: Teijin Ltd
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Filing: 1980-09-02
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Granted: 1982-05-25
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Expires: 2000-09-02
Abstract
Abstract A heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR1## wherein R 1 , R 2 and R 3 each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; a method for producing aforesaid heparin derivative which comprises reacting heparin with a halide or anhydride of an unsaturated carboxylic acid of the formula ##STR2## wherein R 1 , R 2 and R 3 are the same as defined above; and a method for imparting antithrombotic activity to a biomedical material, which comprises treating that surface of the biomedical material which makes contact with the blood with actinic light in the presence of aforesaid heparin derivative.
Inventors
- 👤 Akira Kudo
- 👤 Hiroo Inata
- 👤 Makoto Ogasawara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:59
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
83 words
A method for imparting antithrombotic activity to a biomedical material, which comprises treating that surface of the biomedical material which makes contact with the blood with actinic light in the presence of a heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR8## wherein R 1 , R 2 and R 3 each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.
Claim 2
Independent Claim
83 words
A method for imparting antithrombotic activity to a biomedical material, which comprises treating that surface of the biomedical material which makes contact with the blood with actinic light in the presence of a heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR8## wherein R 1 , R 2 and R 3 each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein at least the surface of said biomedical material is a hydrophilic substance.
Claim 4
Independent Claim
67 words
A method for imparting antithrombotic activity to a biomedical material, which comprises forming at least that surface of the biomedical material which makes contact with the blood from a polymer having a carboxylic acid halide group and/or a carboxylic anhydride group in the side chain, and treating said surface with a solution of heparin wherein at least 0.5% of the entire hydroxyl groups of heparin are esterified.
Claim 5
Independent Claim
67 words
A method for imparting antithrombotic activity to a biomedical material, which comprises forming at least that surface of the biomedical material which makes contact with the blood from a polymer having a carboxylic acid halide group and/or a carboxylic anhydride group in the side chain, and treating said surface with a solution of heparin wherein at least 0.5% of the entire hydroxyl groups of heparin are esterified.
Claim 6
Dependent Claim
26 words
The method of claim 1 wherein both R 1 and R 2 are hydrogen atoms and R 3 is a hydrogen atom or a methyl group.
Claim 7
Dependent Claim
23 words
The method of claim 1 wherein the treatment with actinic light is conducted at a temperature of from -10° C. to 70° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |