US5414075A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Restrained multifunctional reagent for surface modification
Assignee: Surmodics Coatings LLC
•
Filing: 1992-11-06
•
Granted: 1995-05-09
•
Expires: 2012-11-06
Abstract
Abstract A multifunctional reagent is provided that is useful for the attachment of desired molecules to support surfaces. A reactive reagent molecule of the invention is "restrained" in that it is conformationally and/or chemically restricted from reacting with either itself or with other molecules of the same reagent. Upon activation, this feature causes the attachment of less than all of the reactive sites of the multifunctional reagent to a surface, thereby leaving the remaining sites free to react with molecules desired to be immobilized onto the surface.
Inventors
- 👤 Dale G. Swan
- 👤 Charles A. Hastings
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:33
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/58
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
21 words
A restrained, multifunctional reagent selected from the group consisting of the tetrakis (4-benzoylbenzyl ether) and the tetrakis (4-benzoylbenzoate ester) of pentaerthyritol.
Claim 2
Dependent Claim
21 words
A restrained, multifunctional reagent selected from the group consisting of the tetrakis (4-benzoylbenzyl ether) and the tetrakis (4-benzoylbenzoate ester) of pentaerthyritol.
Claim 3
Dependent Claim
18 words
A restrained, multifunctional reagent according to claim 1 wherein the reagent comprises the tetrakis (4-benzoylbenzyl ether) of pentaerythritol.
Claim 4
Dependent Claim
27 words
A restrained, multifunctional reagent according to claim 2 wherein a plurality of the 4-benzoylbenzyl ether groups have been activated in order to attach them to a surface.
Claim 5
Dependent Claim
28 words
A restrained, multifunctional reagent according to claim 2 wherein a plurality of the 4-benzoylbenzyl ether groups have been activated in order to attach them to a target molecule.
Claim 6
Dependent Claim
43 words
A restrained, multifunctional reagent according to claim 2 wherein a plurality of the 4-benzoylbenzyl ether groups have been activated in order to attach them to a target molecule and a different plurality have been activated in order to attach them to a surface.
Claim 7
Dependent Claim
30 words
A restrained, multifunctional reagent according to claim 4 wherein the target molecule is selected from the group consisting of synthetic polymers, carbohydrates, proteins, lipids, nucleic acids, drugs, vitamins, and cofactors.
Claim 8
Dependent Claim
22 words
A restrained, multifunctional reagent according to claim 3 wherein the surface provides abstractable hydrogens suitable for covalent bonding with the activated group.
Claim 9
Dependent Claim
51 words
A restrained, multifunctional reagent according to claim 7 wherein the surface is provided by a support selected from the group consisting of polyolefins, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly (vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, cellulose derivatives, silicones, and rubber-like plastics.
Claim 10
Dependent Claim
18 words
A restrained, multifunctional reagent according to claim 1 wherein the reagent comprises the tetrakis (4-benzoylbenzoate ester) of pentaerythritol.
Claim 11
Dependent Claim
27 words
A restrained, multifunctional reagent according to claim 9 wherein a plurality of the 4-benzoylbenzoate ester groups have been activated in order to attach them to a surface.
Claim 12
Dependent Claim
28 words
A restrained, multifunctional reagent according to claim 9 wherein a plurality of the 4-benzoylbenzoate ester groups have been activated in order to attach them to a target molecule.
Claim 13
Dependent Claim
43 words
A restrained, multifunctional reagent according to claim 9 wherein a plurality of the 4-benzoylbenzoate ester groups have been activated in order to attach them to a target molecule and a different plurality have been activated in order to attach them to a surface.
Claim 14
Dependent Claim
30 words
A restrained, multifunctional reagent according to claim 11 wherein the target molecule is selected from the group consisting of synthetic polymers, carbohydrates, proteins, lipids, nucleic acids, drugs, vitamins, and cofactors.
Claim 15
Dependent Claim
22 words
A restrained, multifunctional reagent according to claim 10 wherein the surface provides abstractable hydrogens suitable for covalent bonding with the activated group.
Claim 16
Dependent Claim
51 words
A restrained, multifunctional reagent according to claim 14 wherein the surface is provided by a support selected from the group consisting of polyolefins, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly (vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, cellulose derivatives, silicones, and rubber-like plastics.
Claim 17
Dependent Claim
10 words
A restrained, multifunctional reagent comprising an acylated derivative of tetraphenylmethane.
Claim 18
Dependent Claim
10 words
A restrained, multifunctional reagent comprising an acylated derivative of tetraphenylmethane.
Claim 19
Dependent Claim
28 words
A restrained, multifunctional reagent according to claim 16 wherein the reagent a plurality of the acyl groups have been activated in order to attach them to a surface.
Claim 20
Dependent Claim
27 words
A restrained, multifunctional reagent according to claim 16 wherein a plurality of the acyl groups have been activated in order to attach them to a target molecule.
Claim 21
Dependent Claim
42 words
A restrained, multifunctional reagent according to claim 16 wherein a plurality of the acyl groups have been activated in order to attach them to a target molecule and a different plurality have been activated in order to attach them to a surface.
Claim 22
Dependent Claim
73 words
A restrained, multifunctional reagent according to claim 19 wherein the target molecule is selected from the group consisting of synthetic polymers, carbohydrates, proteins, lipids, nucleic acids, drugs, vitamins, and cofactors, and the surface is provided by a support selected from the group consisting of polyolefins, polystyrenes, poly(methyl)methacrylates, polyacrylonitriles, poly(vinylacetates), poly (vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, phenolics, amino-epoxy resins, polyesters, cellulose derivatives, silicones, and rubber-like plastics.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-05-08 | 1998-11-07 | 1999-05-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-08 | 2002-11-07 | 2003-05-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-08 | 2006-11-07 | 2007-05-09 | $7700.00 | Window Closed / Lapsed |