US4442133A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotic bonding of vascular prostheses and other implants
Assignee: Rutgers Health
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Filing: 1982-02-22
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Granted: 1984-04-10
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Expires: 2002-02-22
Abstract
Abstract A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.
Inventors
- 👤 Ralph S. Greco
- 👤 Richard A. Harvey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61L27/14; A61L27/16; A61L27/54; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
120 words
The method of preparing a vascular graft comprising the steps of preparing a length of a graft material, soaking said length of graft material in a solution of about 5% by weight of tridodecyl methyl ammonium chloride in ethanol for about 30 minutes at room temperature, washing said graft in distilled water to remove excess tridodecyl methyl ammonium chloride but leaving an adsorbed coating thereon, incubating, for about one hour, the graft carrying the adsorbed coating of tridodecyl methyl ammonium chloride in a solution of antibiotic selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, the cephalosporins, and cefoxitin, washing the graft in sterile water to remove unbound antibiotic, and storing the graft for use in the operating room.
Claim 2
Independent Claim
120 words
The method of preparing a vascular graft comprising the steps of preparing a length of a graft material, soaking said length of graft material in a solution of about 5% by weight of tridodecyl methyl ammonium chloride in ethanol for about 30 minutes at room temperature, washing said graft in distilled water to remove excess tridodecyl methyl ammonium chloride but leaving an adsorbed coating thereon, incubating, for about one hour, the graft carrying the adsorbed coating of tridodecyl methyl ammonium chloride in a solution of antibiotic selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, the cephalosporins, and cefoxitin, washing the graft in sterile water to remove unbound antibiotic, and storing the graft for use in the operating room.
Claim 3
Dependent Claim
12 words
The method defined by claim 1 wherein said graft material is polytetrafluoroethylene.
Claim 4
Dependent Claim
13 words
The method defined in claim 1 wherein said graft material is polyethylene teraphthalate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-10 | 1987-10-10 | 1988-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-10 | 1991-10-10 | 1992-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-10 | 1995-10-10 | 1996-04-10 | $7700.00 | Window Closed / Lapsed |