US4326532A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antithrombogenic articles
Assignee: 3M Co
•
Filing: 1980-10-06
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Granted: 1982-04-27
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Expires: 2000-10-06
Abstract
Abstract A medical article having a layered antithrombogenic surface is useful as a polymeric implant. The article comprises a polymeric substrate coated with chitosan to which is appended an antithrombotic agent. A process for rendering the surface of a polymer antithrombogenic is disclosed.
Inventors
- 👤 Walton J. Hammar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:57
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L27/00; A61L27/28; A61L27/34; Y; Y10; Y10T; Y10T428/00; Y10T428/31504
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
34 words
A medical article of manufacture having a layered nonthrombogenic surface comprising: a natural or synthetic polymeric substrate, a chitosan coating bonded to said polymeric substrate, and an antithrombotic agent bonded to said chitosan coating.
Claim 2
Dependent Claim
34 words
A medical article of manufacture having a layered nonthrombogenic surface comprising: a natural or synthetic polymeric substrate, a chitosan coating bonded to said polymeric substrate, and an antithrombotic agent bonded to said chitosan coating.
Claim 3
Dependent Claim
17 words
The article according to claim 1 wherein said antithrombotic agent is a sulfated polysaccharide, prostaglandin, or albumin.
Claim 4
Dependent Claim
12 words
The article according to claim 2 wherein said antithrombotic agent is heparin.
Claim 5
Dependent Claim
13 words
The article according to claim 1 wherein said polymeric substrate is a catheter.
Claim 6
Dependent Claim
15 words
The article according to claim 1 wherein said polymeric substrate is a kidney dialysis membrane.
Claim 7
Dependent Claim
21 words
The article according to claim 1 wherein said polymeric substrate is silicone rubber, polyethylene, polyvinyl chloride, polyurethane, polypropylene, teflon, or cellulose.
Claim 8
Dependent Claim
27 words
The article according to claim 1 wherein the level of chitosan in said chitosan coating is in the range of about 0.01 to 100 mg/cm 2 .
Claim 9
Dependent Claim
23 words
The article according to claim 7 wherein said level of chitosan in the chitosan coating is about 0.05 to 1.0 mg/cm 2 .
Claim 10
Dependent Claim
23 words
The article according to claim 3 wherein the level of heparin is in the range of about 0.1 to 7.0 I.U.'s/cm 2 .
Claim 11
Dependent Claim
75 words
A process for rendering the surface of a polymer antithrombogenic comprising the steps: (a) priming said polymeric surface so as to render it receptive to the coating of a chitosan salt thereon, (b) coating said chitosan salt from acid solution onto said polymeric surface, (c) reacting the resulting chitosan salt coated polymeric surface with base to convert said chitosan salt to free chitosan, and (d) bonding an antithrombogenic agent to said chitosan coated polymeric article.
Claim 12
Dependent Claim
75 words
A process for rendering the surface of a polymer antithrombogenic comprising the steps: (a) priming said polymeric surface so as to render it receptive to the coating of a chitosan salt thereon, (b) coating said chitosan salt from acid solution onto said polymeric surface, (c) reacting the resulting chitosan salt coated polymeric surface with base to convert said chitosan salt to free chitosan, and (d) bonding an antithrombogenic agent to said chitosan coated polymeric article.
Claim 13
Dependent Claim
30 words
A process according to claim 10 further comprising bonding said chitosan coated polymeric article with said antithrombogenic agent in the presence of a chemically effective amount of a boron hydride.
Claim 14
Dependent Claim
17 words
A process according to claim 11 wherein said boron hydride is NaBH 4 or NaCNBH 3 .
Claim 15
Dependent Claim
22 words
A process according to claim 10 further comprising treating the resulting antithrombogenic article with glutaraldehyde to crosslink the chitosan and antithrombogenic agent.
Claim 16
Dependent Claim
17 words
The process according to claim 10 wherein said chitosan coating is covalently bonded to said polymeric substrate.
Claim 17
Dependent Claim
17 words
The process according to claim 10 wherein said chitosan coating is ionically bonded to said polymeric substrate.
Claim 18
Dependent Claim
17 words
The process according to claim 10 wherein said antithrombotic agent is covalently bonded to said chitosan coating.
Claim 19
Dependent Claim
17 words
The process according to claim 10 wherein said antithrombotic agent is ionically bonded to said chitosan coating.
Claim 20
Dependent Claim
16 words
An article of manufacture comprising a self-supporting film of chitosan with an antithrombotic agent bonded thereto.
Claim 21
Dependent Claim
16 words
An article of manufacture comprising a self-supporting film of chitosan with an antithrombotic agent bonded thereto.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-26 | 1985-10-26 | 1986-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-26 | 1989-10-26 | 1990-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-26 | 1993-10-26 | 1994-04-27 | $7700.00 | Window Closed / Lapsed |