Patent US2969066A successfully refreshed from Google Patents.
US4600652A
Expired / Lapsed
US
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Permanently bonded antithrombogenic polyurethane surface
Assignee: Deseret Medical Inc
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Filing: 1985-04-01
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Granted: 1986-07-15
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Expires: 2005-04-01
Abstract
Abstract An antithrombogenic polyurethane polymer being bound to a support substrate wherein the antithrombogenic agent is reacted through an aldehyde group with an amine functionality of a polyurethane-urea to form the covalently bonded antithrombogenic material.
Inventors
- 👤 Donald D. Solomon
- 👤 Charles W. McGary
- 👤 Vincent J. Pascarella
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:10
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/83; C08G18/84; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0023; A61L33/0029; C08G18/08; C08G18/0804; C08G18/0809; C08G18/0814; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31551; Y10T428/31554
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
46 words
An antithrombogenic polyurethane polymer, which comprises: a. a support substrate; b. a protonated amine rich polyurethane-urea bonded to said support substrate; c. an aldehyde containing antithrombogenic agent reacted through the aldehyde group with the amine functionality of said polyurethane-urea to form a covalently bonded antithrombogenic material.
Claim 2
Dependent Claim
46 words
An antithrombogenic polyurethane polymer, which comprises: a. a support substrate; b. a protonated amine rich polyurethane-urea bonded to said support substrate; c. an aldehyde containing antithrombogenic agent reacted through the aldehyde group with the amine functionality of said polyurethane-urea to form a covalently bonded antithrombogenic material.
Claim 3
Dependent Claim
30 words
The antithrombogenic polyurethane polymer of claim 1 wherein the antithrombogenic agent is selected from the group consisting of aldehyde modified heparin, prostaglandins, urokinase, streptokinase, sulfated polysaccharide, albumin and mixtures thereof.
Claim 4
Dependent Claim
21 words
The antithrombogenic polyurethane polymer of claim 1 wherein the polyurethane polymer is selected from thermosetting polyurethane polymers and thermoplastic polyurethane polymers.
Claim 5
Dependent Claim
22 words
The antithrombogenic polyurethane polymer of claim 1 wherein the protonated amine rich polyurethane-urea is prepared from a polyurethane prepolymer and a diamine.
Claim 6
Dependent Claim
26 words
The antithrombogenic polyurethane polymer of claim 4 wherein the mole ratio of diamine to free isocyanate groups in the prepolymer is from about 0.6:1 to 1:1.
Claim 7
Dependent Claim
33 words
The antithrombogenic polyurethane polymer of claim 1 wherein the aldehyde containing antithrombogenic agent is covalently bonded to the support substrate through the activation of amine groups on the protonated amine rich polyurethane-urea surface.
Claim 8
Dependent Claim
32 words
The antithrombogenic polyurethane polymer of claim 1 wherein the protonated amine is activated with an alkaline buffer to enable covalent coupling to the antithrombogenic agent in the presence of a reducing agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-14 | 1990-01-13 | 1990-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-14 | 1994-01-13 | 1994-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-14 | 1998-01-13 | 1998-07-15 | $7700.00 | Window Closed / Lapsed |