US3755218A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin
Assignee: California Institute of Technology
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Filing: 1970-08-14
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Granted: 1973-08-28
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Expires: 1990-08-14
Abstract
Abstract A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and utilized to form a non-clotting coat on the blood lines in kidney machines.
Inventors
- 👤 Yen S Siao
- 👤 A Rembaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:43
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/28; C08G18/30; C08G18/32; C08G18/3271; C08G18/329; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0023; C08G18/08; C08G18/0804; C08G18/0809; C08G18/0814; C08G18/10; C08G18/3275; C08L; C08L75/00; C08L75/04; Y; Y10; Y10S; Y10S128/00; Y10S128/22; Y10T; Y10T428/00; Y10T428/13; Y10T428/1334; Y10T428/1345; Y10T428/31504; Y10T428/31551; Y10T428/31554; Y10T428/31565; Y10T428/31573; Y10T428/31587; Y10T428/31598; Y10T428/31601
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
39 words
An elastomer according to claim 1 in which the heparin content is between 10 and 15%, and the elastomer is dissolved in a solvent selected from the group consisting of polar solvents and mixtures thereof with an alkyl amine.
Claim 2
Dependent Claim
30 words
An elastomer according to claim 2 in which said solvent is selected from dioxane, acetone, tetrahydrofuran, dimethylformamide and mixtures thereof with 0.01 to 5% of a primary or secondary alkylamine.
Claim 3
Dependent Claim
17 words
An elastomer according to claim 3 in which the solvent is a mixture of dimethylformamide and diaminoheptane.
Claim 4
Dependent Claim
20 words
A method of rendering a surface nonthrombogenic comprising covering said surface with a film comprising the elastomer of claim 1.
Claim 5
Dependent Claim
20 words
A method according to claim 5 in which said surface is prepared by molding a shaped article from said elastomer.
Claim 6
Dependent Claim
19 words
A method according to claim 5 in which said surface is formed by casting a film of said elastomer.
Claim 7
Dependent Claim
28 words
A method according to claim 5 in which said surface is formed by coating a substrate with a solution according to claim 2 and evaporating the solvent therefrom.
Claim 8
Dependent Claim
17 words
An article of manufacture comprising a film of the ionic block elastomer as defined in claim 1.
Claim 9
Dependent Claim
15 words
An article according to claim 9 in which the film is supported on a substrate.
Claim 10
Dependent Claim
26 words
An article according to claim 10 in which the substrate is selected from the group consisting of polyvinyl, polytetrafluoroethylene, polyester, silicone resins, glass, polystyrene and polyurethane.
Claim 11
Dependent Claim
14 words
An article according to claim 9 in which said film is in tubular shape.
References Cited (Backward Citations)
US3453194A
Cited
US3457098A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-08-27 | 1977-02-26 | 1977-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-08-27 | 1981-02-26 | 1981-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-08-27 | 1985-02-26 | 1985-08-28 | $7700.00 | Window Closed / Lapsed |