US4713402A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing antithrombogenic/antibiotic polymeric plastic materials
Assignee: Becton Dickinson and Co
•
Filing: 1985-08-30
•
Granted: 1987-12-15
•
Expires: 2005-08-30
Abstract
Abstract An antithrombogenic/antibiotic plastic material prepared using an organic solvent system containing a specific chlorofluorocarbon compound and petroleum ether.
Inventors
- 👤 Donald D. Solomon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:47
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L29/00; A61L29/14; A61L29/16; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/208; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
196 words
A process for producing plastic substrates having antithrombogenic and/or antibiotic properties without dissolving the substrate, characterized by (a) providing a dual organic solvent system, said dual organic solvent system comprising (1) a chlorofluorocarbon component, said chlorofluorocarbon component being a member selected from the group consisting of 1,1,2-trichloro-1,2,2-trifluoroethane; 1,2-difluoro-1,1,2,2-tetrachloroethane; 1,1-difluoro 1,2,2,2-tetrachloroethane, and mixtures thereof; (2) a petroleum ether component; and (3) the ratio of said chlorofluorocarbon component to said petroleum ether component being within the range of between about nine parts chlorofluorocarbon to one part petroleum ether and one part chlorofluorocarbon to one part petroleum ether; (b) dissolving in said dual organic solvent system from said providing step a pre-formed quaternary ammonium antibiotic and/or antithrombogenic complex; (c) immersing a plastic material in said dual organic solvent system containing said quaternary ammonium antibiotic and/or antithrombogenic complex from said dissolving step, said plastic material being non-dissolvable in said organic solvent system; (d) removing in a first removing step said plastic material from said immersing step; and (e) removing in a second removing step said solvent from said dissolving step; (f) thereby providing a passively coated thin layer film of quaternary ammonium antibiotic and/or anticoagulant complex on said plastic surface.
Claim 2
Dependent Claim
196 words
A process for producing plastic substrates having antithrombogenic and/or antibiotic properties without dissolving the substrate, characterized by (a) providing a dual organic solvent system, said dual organic solvent system comprising (1) a chlorofluorocarbon component, said chlorofluorocarbon component being a member selected from the group consisting of 1,1,2-trichloro-1,2,2-trifluoroethane; 1,2-difluoro-1,1,2,2-tetrachloroethane; 1,1-difluoro 1,2,2,2-tetrachloroethane, and mixtures thereof; (2) a petroleum ether component; and (3) the ratio of said chlorofluorocarbon component to said petroleum ether component being within the range of between about nine parts chlorofluorocarbon to one part petroleum ether and one part chlorofluorocarbon to one part petroleum ether; (b) dissolving in said dual organic solvent system from said providing step a pre-formed quaternary ammonium antibiotic and/or antithrombogenic complex; (c) immersing a plastic material in said dual organic solvent system containing said quaternary ammonium antibiotic and/or antithrombogenic complex from said dissolving step, said plastic material being non-dissolvable in said organic solvent system; (d) removing in a first removing step said plastic material from said immersing step; and (e) removing in a second removing step said solvent from said dissolving step; (f) thereby providing a passively coated thin layer film of quaternary ammonium antibiotic and/or anticoagulant complex on said plastic surface.
Claim 3
Dependent Claim
23 words
The method of claim 1, wherein the antithrombogenic material is selected from the group consisting of heparin, prostaglandins, sulfated polysaccharide, and mixtures thereof.
Claim 4
Dependent Claim
24 words
The method of claim 1, wherein the plastic material is not soluble in the same organic solvent used to dissolve the quaternary ammonium compound.
Claim 5
Dependent Claim
26 words
The method of claim 1, wherein the quaternary ammonium salt having from 2 to 4 alkyl groups each having from about 10 to 30 carbon atoms.
Claim 6
Dependent Claim
27 words
The method of claim 1, wherein the quaternary ammonium compound is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts and tridodecylbenzyl ammonium salts.
Claim 7
Dependent Claim
31 words
The method of claim 1, wherein the antibiotic material is selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, cephalosporins, cefoxitin, cefazolin, dicloxacillin, cloxacillin, and clavulanic acid, and mixtures thereof.
Claim 8
Dependent Claim
43 words
The method of claim 1, wherein the plastic is a member of the group consisting of polyethylene, polypropylene, polyurethanes, polyurethane-silicone copolymers, polyurethane-ureas, polycarbonates, silicone rubber, polyesters, nylons, natural rubber, polyvinyl chloride, acrylics, polystryene, a copolymer of polycarbonate and silicone rubber, and mixtures thereof.
Claim 9
Dependent Claim
154 words
An antithrombogenic/antibiotic plastic material prepared by exposing a polymeric plastic material to a dual organic solvent system in which the polymeric plastic material is non-soluble; said dual organic solvent system having dissolved therein a pre-formed quaternary ammonium antibiotic and/or antithrombogenic complex, said organic solvent system consisting essentially of (1) a chlorofluorocarbon component, said chlorofluorocarbon component being a member selected from the group consisting of 1,1,2trichloro-1,2,2 trifluoroethane; 1,2-difluoro-1,1,2,2-tetra-chloroethane; 1,1-difluoro 1,2,2,2-tetrachloroethane, and mixtures thereof; and (2) petroleum ether, wherein the ratio of said chlorofluorocarbon component to said petroleum ether being within the range of between about nine parts chlorofluorocarbon to one part petroleum ether and one part chlorofluorocarbon to one part petroleum ether, wherein said plastic material is exposed to said dual solvent system for a time sufficient to form a thin film of said complex on the surface of said plastic material, and wherein said dual solvent system is removed from said formed thin film.
Claim 10
Dependent Claim
154 words
An antithrombogenic/antibiotic plastic material prepared by exposing a polymeric plastic material to a dual organic solvent system in which the polymeric plastic material is non-soluble; said dual organic solvent system having dissolved therein a pre-formed quaternary ammonium antibiotic and/or antithrombogenic complex, said organic solvent system consisting essentially of (1) a chlorofluorocarbon component, said chlorofluorocarbon component being a member selected from the group consisting of 1,1,2trichloro-1,2,2 trifluoroethane; 1,2-difluoro-1,1,2,2-tetra-chloroethane; 1,1-difluoro 1,2,2,2-tetrachloroethane, and mixtures thereof; and (2) petroleum ether, wherein the ratio of said chlorofluorocarbon component to said petroleum ether being within the range of between about nine parts chlorofluorocarbon to one part petroleum ether and one part chlorofluorocarbon to one part petroleum ether, wherein said plastic material is exposed to said dual solvent system for a time sufficient to form a thin film of said complex on the surface of said plastic material, and wherein said dual solvent system is removed from said formed thin film.
Claim 11
Dependent Claim
24 words
The plastic material of claim 8 wherein the antithrombogenic material is selected from the group consisting of heparin, prostaglandins, sulfated polysaccharide, and mixtures thereof.
Claim 12
Dependent Claim
35 words
The plastic material of claim 8 wherein the quaternary ammonium compound is a long-chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each having from about 10 to about 30 carbon atoms.
Claim 13
Dependent Claim
28 words
The plastic material of claim 8 wherein the quaternary ammonium compound is selected from the group consisting of tridodecylmethyl ammonium salts, tetradodecyl ammonium salts and tridodecylbenzyl ammonium salts.
Claim 14
Dependent Claim
32 words
The plastic material of claim 8 wherein the antibiotic material is selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, cephalosporins, cefoxitin, cefazolin, dicloxacillin, cloxacillin, and clavulanic acid, and mixtures thereof.
Claim 15
Dependent Claim
44 words
The plastic material of claim 8 wherein the plastic is a member of the group consisting of polyethylene, polypropylene, polyurethanes, polyurethanesilicone copolymers, polyurethane-ureas, polycarbonates, silicone rubber, polyester, nylons, natural rubber, polyvinyl chloride, acrylics, polystyrene, a copolymer of polycarbonate and silicone rubber, and mixtures thereof.
Claim 16
Dependent Claim
12 words
The plastic material of claim 8 for use in making balloon catheters.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-14 | 1991-06-15 | 1991-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-14 | 1995-06-15 | 1995-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-14 | 1999-06-15 | 1999-12-15 | $7700.00 | Window Closed / Lapsed |