US4581028A
Expired / Lapsed
US
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Infection-resistant materials and method of making same through use of sulfonamides
Assignee: Columbia University
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Filing: 1984-04-30
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Granted: 1986-04-08
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Expires: 2004-04-30
Abstract
Abstract Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.
Inventors
- 👤 Charles L. Fox, Jr.
- 👤 Shanta Modak
- 👤 Keith Reemtsma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 19:26
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61B; A61B17/00; A61B17/34; A61L17/00; A61L17/005; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/40; A61L2300/404; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/734; Y10S977/753
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
52 words
A method for reducing the risk of infection by bacteria as a result of prosthetic vascular graft surgery, said method comprising the use of a vascular graft comprising a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamdies.
Claim 2
Independent Claim
52 words
A method for reducing the risk of infection by bacteria as a result of prosthetic vascular graft surgery, said method comprising the use of a vascular graft comprising a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamdies.
Claim 3
Independent Claim
69 words
A method for reducing the risk of infection by bacteria as a result of a device implanted within the interior of a human animal body, said method comprising the use of an implanted device which comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides for at least a portion of the implanted device.
Claim 4
Independent Claim
69 words
A method for reducing the risk of infection by bacteria as a result of a device implanted within the interior of a human animal body, said method comprising the use of an implanted device which comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides for at least a portion of the implanted device.
Claim 5
Dependent Claim
55 words
An infection-resistant device which is a vascular graft prosthesis for use within the interior of a human or animal body wherein at least a portion of said vascular graft prosthesis comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 6
Dependent Claim
55 words
An infection-resistant device which is a vascular graft prosthesis for use within the interior of a human or animal body wherein at least a portion of said vascular graft prosthesis comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 7
Dependent Claim
51 words
An infection-resistant device which is a catheter for use within the interior of a human or animal body wherein at least a portion of said catheter comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 8
Dependent Claim
51 words
An infection-resistant device which is a catheter for use within the interior of a human or animal body wherein at least a portion of said catheter comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 9
Dependent Claim
55 words
An infection-resistant device which is an internal contraceptive device for use within the interior of a human or animal body wherein at least a portion of said internal contraceptive device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 10
Dependent Claim
55 words
An infection-resistant device which is an internal contraceptive device for use within the interior of a human or animal body wherein at least a portion of said internal contraceptive device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 11
Dependent Claim
57 words
An infection-resistant device which is an internal feminine hygiene device for use within the interior of a human or animal body wherein at least a portion of said internal feminine hygiene device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 12
Dependent Claim
57 words
An infection-resistant device which is an internal feminine hygiene device for use within the interior of a human or animal body wherein at least a portion of said internal feminine hygiene device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 13
Dependent Claim
53 words
An infection-resistant device which is a surgical suture for use within the interior of a human or animal body wherein at least a portion of said surgical suture comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 14
Dependent Claim
53 words
An infection-resistant device which is a surgical suture for use within the interior of a human or animal body wherein at least a portion of said surgical suture comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 15
Dependent Claim
53 words
An infection-resistant device which is a vaginal sponge for use within the interior of a human or animal body wherein at least a portion of said vaginal sponge comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 16
Dependent Claim
53 words
An infection-resistant device which is a vaginal sponge for use within the interior of a human or animal body wherein at least a portion of said vaginal sponge comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 17
Dependent Claim
53 words
An infection-resistant device which is a heart valve for use within the interior of a human or animal body wherein at least a portion of said heart valve comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 18
Dependent Claim
53 words
An infection-resistant device which is a heart valve for use within the interior of a human or animal body wherein at least a portion of said heart valve comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 19
Dependent Claim
51 words
An infection-resistant device which is a cannula for use within the interior of a human or animal body wherein at least a portion of said cannular comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 20
Dependent Claim
51 words
An infection-resistant device which is a cannula for use within the interior of a human or animal body wherein at least a portion of said cannular comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 21
Dependent Claim
53 words
An infection-resistant device which is a cosmetic implant for use within the interior of a human or animal body wherein at least a portion of said cosmetic implant comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 22
Dependent Claim
53 words
An infection-resistant device which is a cosmetic implant for use within the interior of a human or animal body wherein at least a portion of said cosmetic implant comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 23
Dependent Claim
57 words
An infection-resistant device which is a bone or joint replacement for use within the interior of a human or animal body wherein at least a portion of said bone or joint replacement comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 24
Dependent Claim
57 words
An infection-resistant device which is a bone or joint replacement for use within the interior of a human or animal body wherein at least a portion of said bone or joint replacement comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.
Claim 25
Dependent Claim
17 words
The infection-resistant device of any one of claims 3-12 wherein said polymeric substrate comprises synthetic polymeric material.
Claim 26
Dependent Claim
23 words
The infection-resistant device of claim 13 wherein said synthetic polymeric material is selected from the group consisting of polyester, polytetrafluoroethylene, polyurethane and polyamide.
Claim 27
Dependent Claim
14 words
The infection-resistant device of claim 14 wherein said synthetic polymeric material is a polyester.
Claim 28
Dependent Claim
13 words
The infection-resistant device of claim 13 wherein said synthetic polymeric material is silicone.
Claim 29
Dependent Claim
18 words
The infection-resistant device of any one of claim 3-12 wherein said polymeric substrate comprises a natural polymeric material.
Claim 30
Dependent Claim
24 words
The infection-resistant device of claim 17 wherein said natural polymeric material is selected from the group consisting of collagenous substances, biological tissues and silk.
Claim 31
Dependent Claim
23 words
The infection-resistant device of any one of claims 3-12 wherein said at least one antimicrobial agent comprises a silver salt of a sulfonamide.
Claim 32
Dependent Claim
16 words
The infection-resistant device of claim 19 wherein said at least one antimicrobial agent comprises silver sulfadiazine.
Claim 33
Dependent Claim
18 words
The infection-resistant device of claim 20 wherein said at least one antimicrobial agent further includes an antibacterial agent.
Claim 34
Dependent Claim
16 words
The infection-resistant device of claim 21 wherein said at least one antibacterial agent is sodium piperacillin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-07 | 1989-10-07 | 1990-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-07 | 1993-10-07 | 1994-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-07 | 1997-10-07 | 1998-04-08 | $7700.00 | Window Closed / Lapsed |