US5263992A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible device with covalently bonded biocompatible agent
Assignee: Surmodics Coatings LLC
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Filing: 1991-10-24
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Granted: 1993-11-23
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Expires: 2011-10-24
Abstract
Abstract The biocompatibility of biomaterials having solid surfaces is improved through coating the same with biocompatible agents. The method for modifying the solid surface to improve biocompatibility employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a different reactive group as capable upon activation of covalently bonding to separate molecules of the biocompatible agent. One of the groups is unresponsive to activation by a stimulus to which the other group is responsive. The method comprises applying stimulus to sequentially activate the groups and covalently bind the different reactive group of the linking moiety to the molecules of the biocompatible agent and to photochemically covalently bind the linking moiety to the solid surface with a sufficient population density to enable the molecules of the biocompatible agent to effectively shield the solid surface and to provide a biocompatible surface.
Inventors
- 👤 Patrick E. Guire
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:50
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/0077; A61L27/28; A61L27/34; A61L33/00; A61L33/0005; A61L33/0011; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/23; A61L2300/40; A61L2300/404; A61L2300/412; A61L2300/414; A61L2300/42; Y; Y10; Y10S; Y10S623/00; Y10S623/924; Y10S623/925
Claims Analysis
Total Claims: 72
Claim 1
Independent Claim
144 words
A biocompatible device comprising a solid surface carrying molecules of a carbohydrate capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the carbohydrate to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the carbohydrate, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the carbohydrate are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 2
Dependent Claim
144 words
A biocompatible device comprising a solid surface carrying molecules of a carbohydrate capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the carbohydrate to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the carbohydrate, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the carbohydrate are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 3
Dependent Claim
148 words
A biocompatible device comprising a solid surface carrying molecules of a fatty acid capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the fatty acid to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the fatty acid, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the fatty acid are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 4
Dependent Claim
148 words
A biocompatible device comprising a solid surface carrying molecules of a fatty acid capable of existing in contact with biological fluid or tissue of a living organism with a net beneficial effect on the organism, and a chemical linking moiety residue covalently binding individual molecules of the fatty acid to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the fatty acid, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the fatty acid are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 5
Dependent Claim
130 words
A biocompatible opthalmic lens having a solid surface, molecules of a synthetic hydrophilic polymer and a chemical linking moiety residue linking individual molecules of the synthetic hydrophilic polymer to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the synthetic hydrophilic polymer, one of the groups being unresponsive to a stimulus to which the other reactive group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the synthetic hydrophilic polymer are positioned sufficiently proximate to one another as to cause said molecules to effective shield the solid surface and to provide a biocompatible effective surface.
Claim 6
Dependent Claim
130 words
A biocompatible opthalmic lens having a solid surface, molecules of a synthetic hydrophilic polymer and a chemical linking moiety residue linking individual molecules of the synthetic hydrophilic polymer to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the synthetic hydrophilic polymer, one of the groups being unresponsive to a stimulus to which the other reactive group responds, the photochemically reactive group residue being bonded to the solid surface so that the individual molecules of the synthetic hydrophilic polymer are positioned sufficiently proximate to one another as to cause said molecules to effective shield the solid surface and to provide a biocompatible effective surface.
Claim 7
Dependent Claim
146 words
Vascular graft tubing having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 8
Dependent Claim
146 words
Vascular graft tubing having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 9
Dependent Claim
18 words
Vascular graft tubing according to claim 4 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 10
Dependent Claim
146 words
A dialysis membrane having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 11
Dependent Claim
146 words
A dialysis membrane having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 12
Dependent Claim
18 words
A dialysis membrane according to claim 6 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 13
Dependent Claim
145 words
A catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 14
Dependent Claim
145 words
A catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 15
Dependent Claim
17 words
A catheter according to claim 8 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 16
Dependent Claim
147 words
An intraaortic balloon catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 17
Dependent Claim
147 words
An intraaortic balloon catheter having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 18
Dependent Claim
19 words
An intraaortic balloon catheter according to claim 10 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 19
Dependent Claim
145 words
A suture having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 20
Dependent Claim
145 words
A suture having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 21
Dependent Claim
17 words
A suture according to claim 12 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 22
Dependent Claim
147 words
A soft tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 23
Dependent Claim
147 words
A soft tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 24
Dependent Claim
19 words
A soft tissue prosthesis according to claim 14 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 25
Dependent Claim
147 words
A hard tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 26
Dependent Claim
147 words
A hard tissue prosthesis having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 27
Dependent Claim
19 words
A hard tissue prosthesis according to claim 16 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 28
Dependent Claim
146 words
An artificial organ, having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 29
Dependent Claim
146 words
An artificial organ, having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 30
Dependent Claim
18 words
An artificial organ according to claim 18 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 31
Dependent Claim
146 words
An opthalmic lens having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 32
Dependent Claim
146 words
An opthalmic lens having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 33
Dependent Claim
18 words
An ophthalmic lens according to claim 20 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 34
Dependent Claim
146 words
A blood oxygenator having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, antithrombogenic agents, synthetic polymers, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 35
Dependent Claim
146 words
A blood oxygenator having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, antithrombogenic agents, synthetic polymers, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 36
Dependent Claim
18 words
A blood oxygenator according to claim 22 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 37
Dependent Claim
146 words
A blood bag having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, antithrombogenic agents, synthetic polymers, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 38
Dependent Claim
146 words
A blood bag having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, antithrombogenic agents, synthetic polymers, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 39
Dependent Claim
18 words
A blood bag according to claim 24 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 40
Dependent Claim
145 words
An ultrafiltration membrane, the membrane having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 41
Dependent Claim
145 words
An ultrafiltration membrane, the membrane having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 42
Dependent Claim
18 words
An ultrafiltration membrane according to claim 26 wherein said antithrombogenic agent is streptokinase, tissue plasminogen activator, or urokinase.
Claim 43
Dependent Claim
31 words
A vascular graft according to claim 4 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 44
Dependent Claim
16 words
A vascular graft according to claim 4 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 45
Dependent Claim
31 words
A dialysis membrane according to claim 6 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 46
Dependent Claim
16 words
A dialysis membrane according to claim 6 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 47
Dependent Claim
30 words
A catheter according to claim 8 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 48
Dependent Claim
15 words
A catheter according to claim 8 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 49
Dependent Claim
32 words
An intraaortic balloon catheter according to claim 10 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 50
Dependent Claim
17 words
An intraaortic balloon catheter according to claim 10 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 51
Dependent Claim
30 words
A suture according to claim 12 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 52
Dependent Claim
15 words
A suture according to claim 12 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 53
Dependent Claim
32 words
A soft tissue prosthesis according to claim 14 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 54
Dependent Claim
17 words
A soft tissue prosthesis according to claim 14 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 55
Dependent Claim
32 words
A hard tissue prosthesis according to claim 16 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 56
Dependent Claim
17 words
A hard tissue prosthesis according to claim 16 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 57
Dependent Claim
31 words
An artificial organ according to claim 18 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 58
Dependent Claim
16 words
An artificial organ according to claim 18 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 59
Dependent Claim
31 words
An opthalmic lens according to claim 20 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 60
Dependent Claim
16 words
An opthalmic lens according to claim 20 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 61
Dependent Claim
31 words
A blood oxygenator according to claim 22 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 62
Dependent Claim
16 words
A blood oxygenator according to claim 22 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 63
Dependent Claim
31 words
A blood bag according to claim 24 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 64
Dependent Claim
16 words
A blood bag according to claim 24 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 65
Dependent Claim
31 words
An ultrafiltration membrane according to claim 26 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 66
Dependent Claim
16 words
An ultrafiltration membrane according to claim 26 wherein the synthetic polymer is a hydrophilic synthetic polymer.
Claim 67
Dependent Claim
147 words
A cell culture device having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 68
Dependent Claim
147 words
A cell culture device having a solid surface carrying molecules of a biocompatible agent selected from the group consisting of growth factors, cell attachment factors, synthetic polymers, antithrombogenic agents, carbohydrates, fatty acids, and antimicrobial agents, and a chemical linking moiety residue covalently binding individual molecules of the biocompatible agent to the solid surface, the chemical linking moiety residue including a residue of a photochemically reactive group covalently bonded to the solid surface, and a residue of a different reactive group covalently bonded to molecules of the biocompatible agent, one of the groups being unresponsive to a stimulus to which the other group responds, the photochemically reactive group residue being bonded to the solid surface so that individual molecules of the biocompatible agent are positioned sufficiently proximate to one another as to cause said molecules to effectively shield the solid surface and to provide a biocompatible effective surface.
Claim 69
Dependent Claim
26 words
A cell culture device according to claim 52 wherein the device is provided in a form selected from the group consisting of plates, sheets, and tubes.
Claim 70
Dependent Claim
35 words
A cell culture device according to claim 52 wherein the device provides a polymeric surface for cell attachment selected from the group consisting of polyvinyl chloride, polyethylene, polypropylene, polyfluorotetraethylene, silicone elastomer, polyurethane, polystyrene, and polyacrylates.
Claim 71
Dependent Claim
32 words
A cell culture device according to claim 52 wherein the biocompatible agent is a growth factor selected from the group consisting of fibronectin, laminin, collagen, endothelial growth factor, and human serum albumin.
Claim 72
Dependent Claim
17 words
A cell culture device according to claim 52 wherein the synthetic polymer is a hydrophilic synthetic polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-22 | 1997-05-24 | 1997-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-22 | 2001-05-24 | 2001-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-22 | 2005-05-24 | 2005-11-23 | $7700.00 | Window Closed / Lapsed |