US5610148A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macroscopically oriented cell adhesion protein for wound treatment
Assignee: Intercytex Ltd
•
Filing: 1995-04-04
•
Granted: 1997-03-11
•
Expires: 2015-04-04
Abstract
Abstract A porous macroscopically undirectionally oriented cell adhesion protein may be used to promote and direct wound healing.
Inventors
- 👤 Robert Brown
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:46
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L27/00; A61L27/50; A61L27/54; A61K; A61K38/00; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/412
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
48 words
A method of treating a wound comprising applying an effective, non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein to the wound, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented.
Claim 2
Independent Claim
48 words
A method of treating a wound comprising applying an effective, non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein to the wound, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented.
Claim 3
Dependent Claim
39 words
A method according to claim 1 for treating a wound so as to promote wound healing, to direct wound healing, to improve the strength of the wound when healed or to improve the appearance of the wound when healed.
Claim 4
Dependent Claim
48 words
A process for producing a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein which process comprises forming and orienting cell adhesion protein fibrils from an aqueous solution thereof by applying continuous unidirectional motion and removing the solvent.
Claim 5
Dependent Claim
48 words
A process for producing a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein which process comprises forming and orienting cell adhesion protein fibrils from an aqueous solution thereof by applying continuous unidirectional motion and removing the solvent.
Claim 6
Dependent Claim
22 words
A process according to claim 3, wherein the concentration of the aqueous solution of cell adhesion protein is at least 0.7 mg/ml.
Claim 7
Dependent Claim
36 words
A wound dressing comprising a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented.
Claim 8
Dependent Claim
36 words
A wound dressing comprising a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented.
Claim 9
Dependent Claim
46 words
A wound dressing comprising a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented, which wound dressing has two or more non-parallel orientation directions.
Claim 10
Dependent Claim
46 words
A wound dressing comprising a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented, which wound dressing has two or more non-parallel orientation directions.
Claim 11
Independent Claim
88 words
A method of treating a wound, comprising the steps of: a) applying a non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented to the wound and b) allowing the wound to heal while in contact with said macroscopically unidirectionally oriented cell adhesion protein in order to promote wound healing, direct wound healing or improve the appearance or strength of a healed wound.
Claim 12
Independent Claim
88 words
A method of treating a wound, comprising the steps of: a) applying a non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented to the wound and b) allowing the wound to heal while in contact with said macroscopically unidirectionally oriented cell adhesion protein in order to promote wound healing, direct wound healing or improve the appearance or strength of a healed wound.
Claim 13
Independent Claim
70 words
A method of treating a wound, comprising the steps of: a) applying a non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented to the wound and b) allowing the growth of autograft material promoted or directed by said macroscopically unidirectionally oriented cell adhesion protein.
Claim 14
Independent Claim
70 words
A method of treating a wound, comprising the steps of: a) applying a non-toxic amount of a porous macroscopically unidirectionally oriented cell adhesion protein selected from the group consisting of fibronectin, vitronectin and von Willebrand protein in which fibrils of the cell adhesion protein are macroscopically unidirectionally oriented to the wound and b) allowing the growth of autograft material promoted or directed by said macroscopically unidirectionally oriented cell adhesion protein.
Claim 15
Dependent Claim
33 words
A porous, macroscopically unidirectionally oriented cell adhesion protein, which is selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion are macroscopically unidirectionally oriented.
Claim 16
Dependent Claim
33 words
A porous, macroscopically unidirectionally oriented cell adhesion protein, which is selected from the group consisting of fibronectin, vitronectin and von Willebrand protein, in which fibrils of the cell adhesion are macroscopically unidirectionally oriented.
Claim 17
Dependent Claim
16 words
The porous macroscopically unidirectionally oriented cell adhesion protein of claim 9 further comprising a therapeutic agent.
Claim 18
Dependent Claim
21 words
The porous macroscopically unidirectionally oriented cell adhesion protein of claim 10 wherein the therapeutic agent is one which promotes wound healing.
Claim 19
Dependent Claim
23 words
The porous macroscopically unidirectionally oriented cell adhesion protein of claim 11 wherein the therapeutic agent which promotes wound healing is a growth factor.
Claim 20
Dependent Claim
9 words
A protein according to claim 9 which is fibronectin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-10 | 2000-09-09 | 2001-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-10 | 2004-09-09 | 2005-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-10 | 2008-09-09 | 2009-03-11 | $7700.00 | Window Closed / Lapsed |