Patent US1514233A successfully refreshed from Google Patents.
EP0416250A2
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EP
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N-acylurea and O-acylisourea derivatives of hyaluronic acid
Assignee: Research Foundation of the State University of New York
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Filing: 1990-07-16
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Granted: —
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Expires: 2010-07-16
Abstract
Abstract N-Acylureas and O-acylisoureas prepared by the reaction of a carbodiimide or a biscarbodiimide with hyaluronic acid are useful as vitreous replacements, joint cushions or adjuncts in wound healing.
Inventors
- 👤 Glenn D. Prestwich
- 👤 Jing-Wen Kuo
- 👤 David A. Swann
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 17:41
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072; A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61L; A61L27/00; A61L27/14; A61L27/20; A61L31/00; A61L31/04; A61L31/042
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
28 words
A compound selected from the group consisting of the N-acylurea and O-acylisourea derivative of hyaluronic acid or a salt thereof; said derivative being free of chemically bound collagen.
Claim 2
Dependent Claim
28 words
A compound selected from the group consisting of the N-acylurea and O-acylisourea derivative of hyaluronic acid or a salt thereof; said derivative being free of chemically bound collagen.
Claim 3
Dependent Claim
31 words
The compound of claim 1 wherein the hyaluronic acid has a weight average molecular weight of from about 100,000 to about 12,000,000 Daltons determined by calculation from the limiting viscosity number.
Claim 4
Dependent Claim
27 words
The compound of claim 1 prepared by reaction of the acid or salt with a member selected from the class consisting of a carbodiimide and a biscarbodiimide.
Claim 5
Dependent Claim
38 words
The compound of claim 3 wherein the member is a carbodiimide selected from those of the formula: R¹-N=C=N-R² wherein R¹ and R² are each independently selected from the group consisting of hydrogen, hydrocarbyl, substituted-hydrocarbyl, alkoxy, aryloxy and alkaryloxy.
Claim 6
Dependent Claim
17 words
The compound of claim 4 wherein at least one of R¹ and R² is an amino-substituted hydrocarbyl.
Claim 7
Dependent Claim
10 words
The compound of claim 5 wherein the member is 1-ethyl-3-(6-benzyloxycarbonylaminohexyl)-carbodiimide.
Claim 8
Dependent Claim
11 words
The compound of claim 5 wherein the member is 1-(3-dimethylaminopropyl)-3(6-benzoyloxyl- carbonylaminohexyl)carbodiimide.
Claim 9
Dependent Claim
10 words
The compound of claim 5 wherein the member is 1-(3-dimethylaminopropyl-3-ethylcarbodiimide.
Claim 10
Dependent Claim
19 words
The compund of claim 1 which is the reaction product of 1-ethyl-3-tridecyl-carbodiimide and hyaluronic acid or a salt thereof.
Claim 11
Dependent Claim
20 words
The compound of claim 1 which is the reaction product of 1-ethyl-3-octyl carbodiimide and hyaluronic acid or a salt thereof.
Claim 12
Dependent Claim
55 words
The compound of claim 3 wherein the member is a biscarbodiimide selected from those of the formula: R¹ - N = C = N - R² - N = C = N - R³ wherein R¹ amd R² have the same meanings ascribed to them in claim 4 and R³ has the meaning given R¹.
Claim 13
Dependent Claim
10 words
The compound of claim 11 wherein the member is p-phenylenebis(ethyl)carbodiimide.
Claim 14
Dependent Claim
10 words
The compound of claim 11 wherein the member is 1,6-hexylenebis(ethyl)carbodiimide.
Claim 15
Dependent Claim
5 words
The N-acylurea of claim 1.
Claim 16
Dependent Claim
5 words
The O-acylisourea of claim 1.
Claim 17
Independent Claim
17 words
A device which comprises a water-insoluble N-acylurea or an O-acylisourea derivative of hyaluronic acid and a biscarbodiimide.
Claim 18
Independent Claim
17 words
A device which comprises a water-insoluble N-acylurea or an O-acylisourea derivative of hyaluronic acid and a biscarbodiimide.
Claim 19
Dependent Claim
12 words
A water-soluble N-acylurea or O-acylisourea derivative of hyaluronic acid and a carbodiimide.
Claim 20
Dependent Claim
12 words
A water-soluble N-acylurea or O-acylisourea derivative of hyaluronic acid and a carbodiimide.
References Cited (Backward Citations)
No citation records indexed.
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