EP0406428A1
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EP
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Peptide derivatives and their use
Assignee: AGC Inc
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Filing: 1989-09-08
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Granted: —
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Expires: 2009-09-08
Abstract
Abstract The invention provides peptide derivatives comprising synthetic cyclic peptides represented by formula (I), or salts thereof, wherein R represents an amino acid residue or an oligo- or polypeptide residue, and a pharmaceutical agent containing said derivative as an active ingredient and inhibiting adhesion of animal cells to a substrate. The peptide derivatives are stable to hydrolysis by enzymes, and the pharmaceutical agent is effective in inhibiting adhesion of animal cells to a substrate, depressing metastasis of cancer cells, and inhibiting agglutination of platelets.
Inventors
- 👤 Masataka Ohba
- 👤 Hiromichi Kumagai
- 👤 Shunsaku Harie
- 👤 Keiichi Uchida
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:38
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/12; C07K5/126; A; A61; A61P; A61P35/00; A61P43/00; A61P7/00; A61P7/02; C07K14/00; C07K14/435; C07K14/745; C07K14/75; C07K14/78; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
31 words
Peptide derivatives composed of a synthetic cyclic peptide to be represented by the following formula [I], or its salts: (where: R denotes an amino acid residual group or oligo-polypeptide residual group).
Claim 2
Dependent Claim
31 words
Peptide derivatives composed of a synthetic cyclic peptide to be represented by the following formula [I], or its salts: (where: R denotes an amino acid residual group or oligo-polypeptide residual group).
Claim 3
Dependent Claim
22 words
The peptide derivatives according to Claim 1, wherein R is oligo-polypeptide residual group containing 16 or below of amino acid residual groups.
Claim 4
Dependent Claim
32 words
The peptide derivatives according to Claim 1, wherein said sysnthetic cyclic peptide is represented by the following formula [II]: (where: R l denotes an amino acid residual group or oligo-polypeptide residual group).
Claim 5
Dependent Claim
58 words
The peptide derivatives according to Claim 1, wherein R is an oligopeptide residual group represented by the following formula [IV]: (where: [ ] denotes a residual group which is existent or non-existent, and, when R 3 exists, R 3 denotes an amino acid residual group or oligo-polypeptide residual group containing 7 or below of amino acid residual groups).
Claim 6
Dependent Claim
25 words
A synthetic cyclic peptide to be represented by any of the following formulae (where an amino acid residual group is indicated by a single letter):
Claim 7
Dependent Claim
25 words
A synthetic cyclic peptide to be represented by any of the following formulae (where an amino acid residual group is indicated by a single letter):
Claim 8
Dependent Claim
27 words
A drug capable of inhibiting adhesion of animal cells, containing therein, as an effective component, the peptide derivatives according to any one of Claims 1 to 5.
Claim 9
Dependent Claim
15 words
The drug according to Claim 6, wherein said animal cells are somatic cells of mammals.
Claim 10
Dependent Claim
13 words
The drug according to Claim 6, wherein said animal cells are cancer cells.
Claim 11
Dependent Claim
27 words
A drug capable of inhibiting aggregation of blood platelets containing therein, as an effective component, the peptide derivatives according to any one of Claims 1 to 5.
References Cited (Backward Citations)
No citation records indexed.
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