US4955892A
Expired / Lapsed
US
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Neural cell adhesion protein nerve prosthesis
Assignee: Louisiana State University
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Filing: 1988-10-24
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Granted: 1990-09-11
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Expires: 2008-10-24
Abstract
Abstract The neural cell adhesion molecule is used in nerve prostheses for the repair of peripheral nerve damage in mammals, both animal and man. In particular, in a process wherein a crushed or severed nerve ending is entubulated by use of a prosthetic device, a neural cell adhesion protein is added to the prosthetic device to increase the rate of growth of the fibrous components of the nerve, to more rapidly regenerate the nerve, and provide a more complete restitution of the function of the muscle served by the regenerated nerve.
Inventors
- 👤 Joanne K. Daniloff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:23
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; A; A61; A61F; A61F2/00; A61F2/02; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L2430/00; A61L2430/32; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/839
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
119 words
In a process wherein the severed ends of the peripheral nerve of a living mammal, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.
Claim 2
Dependent Claim
119 words
In a process wherein the severed ends of the peripheral nerve of a living mammal, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.
Claim 3
Dependent Claim
41 words
The process of claim 1 wherein the implanted prosthetic device is of tubular shape, the neural cell adhesion protein is added to the tubular opening therethrough, and to the proximate and distal nerve ends, respectively, are sutured to the ends thereof.
Claim 4
Dependent Claim
23 words
The process of claim 1 wherein the neural cell adhesion protein that is added to said implanted prosthetic device is admixed with collagen.
Claim 5
Dependent Claim
31 words
The process of claim 3 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein: collagen ranging from about 0.1:1 to about 10:1.
Claim 6
Dependent Claim
30 words
The process of claim 4 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:collagen ranging from about 0.4:1 to about 1:1.
Claim 7
Dependent Claim
29 words
The process of claim 1 wherein the neural cell adhesion protein is obtained from a mammal of the same species as that in which the prosthetic device is implanted.
Claim 8
Dependent Claim
22 words
The process of claim 6 wherein the neural cell adhesion protein is obtained by extraction from the brains of a sacrificed animal.
Claim 9
Dependent Claim
35 words
The process of claim 7 wherein the neural cell adhesion protein is obtained by extraction from the brains of a sacrificed mammal of the same species as that in which the prosthetic device is implanted.
Claim 10
Dependent Claim
119 words
In a process wherein the severed ends of the peripheral nerve of a living human, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.
Claim 11
Dependent Claim
119 words
In a process wherein the severed ends of the peripheral nerve of a living human, the function of which is to serve a muscle impaired by the break in the nerve, are directed via the use of an implanted prosthetic device to guide the proximate nerve end toward the distal nerve end to regenerate and repair the nerve the improvement comprising adding neural cell adhesion protein to the severed nerve ends held within said implanted prosthetic device sufficient to increase the rate of growth of the nerve vis-a-vis an implant device otherwise similar except that it does not contain said neural cell adhesion protein, to regenerate the nerve, and provide greater restitution of the muscle served by the nerve.
Claim 12
Dependent Claim
40 words
The process of claim 9 wherein the implanted prosthetic device is of tubular shape, the neural cell adhesion protein is added to the tubular opening therethrough, and the proximate and distal nerve ends, respectively, are sutured to the ends thereof.
Claim 13
Dependent Claim
22 words
The process of claim 9 wherein the neural cell adhesion protein is added to said implanted prosthetic device is admixed with collagen.
Claim 14
Dependent Claim
30 words
The process of claim 11 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:collagen ranging from about 0.1:1 to about 10:1.
Claim 15
Dependent Claim
30 words
The process of claim 12 wherein the neural cell adhesion protein and collagen are admixed in weight ratio of neural cell adhesion protein:collagen ranging from about 0.4:1 to about 1:1.
Claim 16
Dependent Claim
16 words
The process of claim 9 wherein the neural cell adhesion protein is obtained from a human.
References Cited (Backward Citations)
US4662884A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-10 | 1994-03-12 | 1994-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-10 | 1998-03-12 | 1998-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-10 | 2002-03-12 | 2002-09-11 | $7700.00 | Window Closed / Lapsed |