EP0517174A2
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EP
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LFA-3 protein and derivatives
Assignee: Kanegafuchi Chemical Industry Co Ltd
•
Filing: 1992-06-03
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Granted: —
•
Expires: 2012-06-03
Abstract
Abstract A sheep LFA-3 protein and derivertives thereof, and derivertives of a human LFA-3 protein, gene coding for the proteins, and processes for preparing the proteins. Said proteins have high affinity for human T-cells.
Inventors
- 👤 Kenji c/o Kanegafuchi Kagaku Kogyo Yamashita
- 👤 Takaaki Ohara
- 👤 Hideo Niwa
- 👤 Fumio Osakada
- 👤 Takeshi Fukuchi
- 👤 Tadahiro Edamura
- 👤 Tetsu Kakutani
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 15:31
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K14/70503; C07K14/70528; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
4 words
A sheep LFA-3 protein.
Claim 2
Dependent Claim
16 words
The protein of Claim 1 which comprises the amino acid sequence of SEQ ID NO: 31.
Claim 3
Dependent Claim
8 words
A gene coding for a sheep LFA-3 protein.
Claim 4
Dependent Claim
8 words
A LFA-3 like protein deficient in TM region.
Claim 5
Dependent Claim
10 words
The protein of Claim 4 which is derived from sheep.
Claim 6
Dependent Claim
10 words
The protein of Claim 4 which is derived from humans.
Claim 7
Dependent Claim
12 words
A gene coding for a LFA-3 like protein deficient in TM region.
Claim 8
Dependent Claim
10 words
The gene of Claim 7 which is derived from sheep.
Claim 9
Dependent Claim
48 words
A process for preparing a LFA-3 like protein deficient in TM region, which comprises culturing a cell which is transformed by a vector including a DNA coding for a LFA-3 like protein deficient in TM region and successively separating the produced LFA-3 like protein deficient in TM region.
Claim 10
Dependent Claim
12 words
The process of Claim 9, wherein the transformed cell is E. coli.
Claim 11
Dependent Claim
18 words
The process of Claim 9, wherein the LFA-3 like protein deficient in TM region is derived from sheep.
Claim 12
Dependent Claim
18 words
The process of Claim 10, wherein the LFA-3 like protein deficient in TM region is derived from sheep.
Claim 13
Dependent Claim
18 words
The process of Claim 9 wherein the LFA-3 like protein deficient in TM region is derived from humans.
Claim 14
Dependent Claim
18 words
The process of Claim 10 wherein the LFA-3 like protein deficient in TM region is derived from humans.
Claim 15
Dependent Claim
8 words
A LFA-3 like protein deficient in D2 region.
Claim 16
Dependent Claim
10 words
The protein of Claim 15 which is derived from sheep.
Claim 17
Dependent Claim
10 words
The protein of Claim 15 which is derived from humans.
Claim 18
Dependent Claim
12 words
A gene coding for a LFA-3 like protein deficient in D2 region.
Claim 19
Dependent Claim
10 words
The gene of Claim 18 which is derived from sheep.
Claim 20
Dependent Claim
10 words
The gene of Claim 18 which is derived from humans.
Claim 21
Dependent Claim
12 words
A soluble derivative of a LFA-3 like protein deficient in D2 region.
Claim 22
Dependent Claim
12 words
The protein of Claim 21 which is derived from sheep or humans.
Claim 23
Dependent Claim
64 words
The protein of Claim 21 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 1 is maintained and, in the sequence from the 95th amino acid to the 131st amino acid in SEQ ID NO: 1, a deficiency of at least one amino acid and/or a substitution of sequence exist(s).
Claim 24
Dependent Claim
64 words
The protein of Claim 22 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 1 is maintained and, in the sequence from the 95th amino acid to the 131st amino acid in SEQ ID NO: 1, a deficiency of at least one amino acid and/or a substitution of sequence exist(s).
Claim 25
Dependent Claim
62 words
The protein of Claim 21 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 95th amino acid to the 134th amino acid in SEQ ID NO: 13, a deficiency of at least one amino acid and/or a substitution exits(s).
Claim 26
Dependent Claim
62 words
The protein of Claim 22 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 95th amino acid to the 134th amino acid in SEQ ID NO: 13, a deficiency of at least one amino acid and/or a substitution exits(s).
Claim 27
Dependent Claim
61 words
The protein of Claim 21 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 93rd amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 94th amino acid to the 134th amino acid in SEQ ID NO:13, a deficiency of at least one amino acid and/or a substitution exist(s).
Claim 28
Dependent Claim
61 words
The protein of Claim 22 which has an amino acid sequence wherein the sequence from the 1st amino acid to the 93rd amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 94th amino acid to the 134th amino acid in SEQ ID NO:13, a deficiency of at least one amino acid and/or a substitution exist(s).
Claim 29
Dependent Claim
25 words
A soluble derivative of a LFA-3 like protein deficient in D2 region containing at least one cysteine residue which is derived from sheep or humans.
Claim 30
Dependent Claim
60 words
A process for preparing a soluble derivative of a LFA-3 like protein deficient in D2 region which comprises culturing a cell which is transformed by a vector including a DNA coding for a soluble derivative of a LFA-3 like protein deficient in D2 region and successively separating the produced soluble derivative of the LFA-3 like protein deficient in D2 region.
Claim 31
Dependent Claim
24 words
The process of Claim 30 wherein the soluble derivative of the LFA-3 like protein deficient in D2 region is derived from sheep or humans.
Claim 32
Dependent Claim
94 words
A process for preparing a derivative of a LFA-3 like protein which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 1 is maintained and, in the sequence from the 95th amino acid to the 131st amino acid in SEQ ID NO: 1, a deficiency of at least one amino acid and/or a substitution of sequence exist(s), which comprises culturing a cell which is transformed by a vector including a DNA coding for said protein and successively separating the produced protein.
Claim 33
Dependent Claim
92 words
A process for preparing a derivative of a LFA-3 like protein which has an amino acid sequence wherein the sequence from the 1st amino acid to the 94th amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 95th amino acid to the 134th amino acid in SEQ ID NO: 13, a deficiency of at least one amino acid and/or a substitution exits(s), which comprises culturing a cell which is transformed by a vector including a DNA coding for said protein and successively separating the produced protein.
Claim 34
Dependent Claim
90 words
A process for preparing a derivative of LFA-3 like protein which has an amino acid sequence wherein the sequence from the 1st amino acid to the 93rd amino acid in SEQ ID NO: 13 is maintained and, in the sequence from the 94th amino acid to the 134th amino acid in SEQ ID NO:13, a deficiency of at least one amino acid and/or a substitution exist(s), which comprises culturing a cell which is transformed by a vector including a DNA coding for said protein and successively separating the produced protein.
Claim 35
Dependent Claim
18 words
A carrier onto which a soluble derivative of a LFA-3 like protein deficient in D2 region is immobilized.
Claim 36
Dependent Claim
20 words
The carrier of Claim 35, wherein the soluble derivative of the LFA-3 like protein is derived from sheep or humans.
Claim 37
Dependent Claim
29 words
A process for preparing a soluble derivative of a LFA-3 like protein deficient in D2 region containing at least one cysteine residue which is derived from sheep or humans.
References Cited (Backward Citations)
No citation records indexed.
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