Patent US6843807B1 successfully refreshed from Google Patents.
US6843807B1
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Osteoimplant
Assignee: Warsaw Orthopedic Inc
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Filing: 2000-04-05
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Granted: 2005-01-18
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Expires: 2020-04-05
Abstract
Abstract An osteoimplant comprises a solid aggregate of bone derived elements, adjacent bone-derived elements being bonded to each other through chemical linkages between their adjacent surface-exposed collagen. Various other components can be incorporated into the bone implant material such as bone-growth inducing substances.
Inventors
- 👤 Todd M. Boyce
- 👤 Albert Manrique
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:24
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/46; A61F2/4644; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/70; A61B17/7062; A61F2/28; A61F2/44; A61F2/4455; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/3695; A61F2/2875; A61F2/3094; A61F2/442; A61F2002/2817; A61F2002/2825; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30057; A61F2002/30059; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30125; A61F2002/30138; A61F2002/30153; A61F2002/30154; A61F2002/30199; A61F2002/30224; A61F2002/30225; A61F2002/30261; A61F2002/30316; A61F2002/30329; A61F2002/30448; A61F2002/30535; A61F2002/30593; A61F2002/30599; A61F2002/30667; A61F2002/30677; A61F2/30942; A61F2002/30957; A61F2002/4649; A61F2220/00; A61F2220/0025; A61F2220/005; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0008; A61F2230/0017; A61F2230/0019; A61F2230/0021; A61F2230/0063; A61F2230/0069; A61F2230/0082; A61F2250/00; A61F2250/0058; A61F2250/006; A61F2250/0063; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
76 words
An osteoimplant consisting essentially of a solid aggregate of superficially demineralized bone-derived elements bonded to each other through covalent chemical linkages between their surface-exposed collagen, wherein the chemical linkages are formed by a chemical crosslinking agent, and wherein the solid aggregate of bone-derived elements possesses a compression strength of from about 10 to about 200 MPa, said elements made from bone particles superficially demineralized such that they retain a high proportion of their original mineral content.
Claim 2
Dependent Claim
76 words
An osteoimplant consisting essentially of a solid aggregate of superficially demineralized bone-derived elements bonded to each other through covalent chemical linkages between their surface-exposed collagen, wherein the chemical linkages are formed by a chemical crosslinking agent, and wherein the solid aggregate of bone-derived elements possesses a compression strength of from about 10 to about 200 MPa, said elements made from bone particles superficially demineralized such that they retain a high proportion of their original mineral content.
Claim 3
Dependent Claim
28 words
The osteoimplant of claim 1 wherein substantially all of the superficially demineralized bone-derived elements are superficially demineralized particles, strips or sheets of allogenic, xenogenic, cortical or cancellous bone.
Claim 4
Dependent Claim
21 words
The osteoimplant of claim 1 containing at least one additional component selected from the group consisting of reinforcing particles and filler.
Claim 5
Dependent Claim
50 words
The osteoimplant of claim 3 wherein the reinforcing particles are selected from the group consisting of fully mineralized bone, graphite, pyrolytic carbon and mixtures thereof, and the filler is selected from the group consisting of hydroxyapatite, tricalcium phosphate, other calcium salts, bioglass, bioceramic, bioabsorbable polymer, nonbioabsorbable material and mixtures thereof.
Claim 6
Dependent Claim
29 words
The osteoimplant of claim 1 containing an additional component selected from the group consisting of bone-growth inducing substance, growth factors, cellular material, genetic material, calcification-controlling agent and hydration agent.
Claim 7
Dependent Claim
40 words
The osteoimplant of claim 1 possessing a cross section for at least a portion of its length which is, or approximates, a circle, oval or polygon, the implant optionally possessing a cavity for at least a portion of its length.
Claim 8
Dependent Claim
9 words
The osteoimplant of claim 1 possessing a hydration-facilitating agent.
Claim 9
Dependent Claim
11 words
The osteoimplant of claim 7 wherein the hydration-facilitating agent is glycerol.
Claim 10
Dependent Claim
23 words
The osteoimplant of claim 1 wherein the chemical linkages are formed by exposing the superficially demineralized bone-derived elements to a chemical crosslinking agent.
Claim 11
Dependent Claim
39 words
The osteoimplant of claim 9 wherein the chemical crosslinking agent is selected from the group consisting of monoaldehydes, dialdehydes, polyepoxy compounds, polyvalent metallic oxides, organic tannins, phenolic oxides derived from plants, hydrazide, dicyclohexyl carbodiimide, hexamethylene diisocyanate, sugars and enzymes.
Claim 12
Dependent Claim
30 words
The osteoimplant of claim 9 wherein the superficially demineralized bone-derived elements are exposed to the chemical crosslinking agent by placing said bone-derived elements in a solution of chemical crosslinking agent.
Claim 13
Dependent Claim
32 words
The osteoimplant of claim 9 , wherein the superficially demineralized bone-derived elements are exposed to the chemical crosslinking agent by exposing the said bone-derived elements to vapors of the chemical crosslinking agent.
Claim 14
Dependent Claim
14 words
The osteoimplant of claim 9 wherein the chemical crosslinking agent is a polyepoxy compound.
Claim 15
Dependent Claim
15 words
The osteoimplant of claim 9 wherein the chemical crosslinking agent is a monoaldehyde or dialdehyde.
Claim 16
Dependent Claim
12 words
The osteoimplant of claim 9 wherein the chemical crosslinking agent is formalin.
Claim 17
Dependent Claim
16 words
The osteoimplant of claim 9 , wherein the chemical crosslinking agent is polyethylene glycol diglycidyl ether.
Claim 18
Dependent Claim
46 words
The osteoimplant of claim 9 containing an additional component selected from the group consisting of bone-growth inducing substances, growth factors, adhesives, plasticizers, flexibilizing agents, cellular material, genetic material, calcification-controlling agents, hydration facilitating agents, biostatic agents, biocidal agents, polymers, inorganic compounds, substances imparting radiopacity and metallic meshes.
Claim 19
Dependent Claim
24 words
The osteoimplant of claim 9 wherein the bone-derived elements are superficially demineralized sheets obtained by longitudinally slicing the diaphyseal region of whole cortical bone.
Claim 20
Dependent Claim
13 words
The osteoimplant of claim 18 wherein each sheet is approximately 1.5 mm thick.
Claim 21
Dependent Claim
24 words
The osteoimplant of claim 18 wherein the sheets are assembled into a layered structure prior to exposing the sheets to a chemical crosslinking agent.
Claim 22
Dependent Claim
17 words
The osteoimplant of claim 20 possessing a total thickness of from about 2 to about 20 mm.
Claim 23
Dependent Claim
13 words
The osteoimplant of claim 18 configured and dimensioned as a square or rectangle.
Claim 24
Dependent Claim
11 words
The osteoimplant of claim 18 configured and dimensioned as a cylinder.
Claim 25
Dependent Claim
40 words
The osteoimplant of claim 18 configured and dimensioned as an intervertebral insert, a long bone, a cranial bone, a bone of the pelvis, a bone of the hand, a bone of the foot or section of any of the foregoing.
Claim 26
Dependent Claim
22 words
The osteoimplant of claim 9 wherein the solid aggregate of bone-derived elements possesses a network of pores, perforations, apertures, channels, or spaces.
Claim 27
Dependent Claim
17 words
The osteoimplant of claim 25 having incorporated therein one or more bone-growth inducing or bone healing substances.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2008-01-18 | 2008-07-19 | 2009-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2012-01-18 | 2012-07-19 | 2013-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2016-01-18 | 2016-07-19 | 2017-01-18 | $7700.00 | Window Closed / Lapsed |