US4678470A
Expired / Lapsed
US
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Bone-grafting material
Assignee: Baxter International Inc
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Filing: 1985-05-29
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Granted: 1987-07-07
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Expires: 2005-05-29
Abstract
Abstract A bone grafting material is derived from allogenic or xenogenic bone by a process that includes tanning with glutaraldehyde. The bone may be pulverized, used as a large block, or machined into a precise pre-determined shape, depending on the bone defect to be repaired. Glutaraldehyde tanning of bone yields a stabilized, highly biocompatible, and non-antigenic material which becomes incorporated into host bone when placed adjacent to it.
Inventors
- 👤 Aws S. Nashef
- 👤 Todd D. Campbell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:55
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/14; A61L27/22; A61L27/222; A61L27/3604; A61L27/3608; A61F2002/2835; A61F2002/2839; A61F2310/00; A61F2310/00005; A61F2310/00365; A61F2310/00383
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
41 words
A method of preparing a biocompatible, stable, and non-antigenic bone grafting material from allogenic or xenogenic bone stock comprising (a) machining a bone segment to the desired dimensions (b) tanning the bone segment by treating it with glutaraldehyde under tanning conditions.
Claim 2
Independent Claim
41 words
A method of preparing a biocompatible, stable, and non-antigenic bone grafting material from allogenic or xenogenic bone stock comprising (a) machining a bone segment to the desired dimensions (b) tanning the bone segment by treating it with glutaraldehyde under tanning conditions.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the bone segment is treated with a tanning solution containing glutaraldehyde in a concentration sufficient to substantially cross-link the proteins in the bone segment.
Claim 4
Dependent Claim
23 words
The method of claim 2 wherein the bone segment is treated with a tanning solution comprising about 0.2% to about 0.8% (w/v) glutaraldehyde.
Claim 5
Dependent Claim
14 words
The method of claim 3 wherein said tanning solution comprises about 0.6% (w/v) glutaraldehyde.
Claim 6
Dependent Claim
13 words
The method of claim 2 wherein said tanning solution further comprises a buffer.
Claim 7
Dependent Claim
10 words
The method of claim 5 wherein said buffer comprises HEPES.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein said tanning conditions include a physiological pH.
Claim 9
Dependent Claim
15 words
The method of claim 7 wherein said pH ranges from about 6.8 to about 7.4.
Claim 10
Dependent Claim
28 words
The method of claim 1 wherein the bone segment is treated with glutaraldehyde for a length of time sufficient to substantially cross-link the proteins in the bone segment.
Claim 11
Dependent Claim
20 words
The method of claim 9 wherein the bone segment is treated with glutaraldehyde for a minimum of about one month.
Claim 12
Dependent Claim
25 words
The methods of claim 1, 2, 5, 7 or 9 wherein the degree of cross-linking is sufficient to render the bone biocompatible, stable and non-antigenic.
Claim 13
Dependent Claim
18 words
The method of claim 1 additionally comprising treating the bone segment with a protease to increase matrix porosity.
Claim 14
Dependent Claim
21 words
The method of claim 1 or 12 additionally comprising extracting the bone segment with an organic solvent to increase matrix porosity.
Claim 15
Dependent Claim
12 words
The method of claim 1 additionally comprising sterilizing the bone grafting material.
Claim 16
Dependent Claim
19 words
The method of claim 1 additionally comprising surface defatting and removing machining oils from the bone segment with ethanol.
Claim 17
Dependent Claim
11 words
The method of claim 1 additionally comprising demineralizing the bone segment.
Claim 18
Independent Claim
48 words
A method of preparing a biocompatible and non-antigenic bone grafting material from allogenic or xenogenic bone stock, comprising: (a) pulverizing a bone segment to obtain pulverized bone; (b) tanning the pulverized bone with glutaraldehyde under tanning conditions; (c) combining the pulverized bone with a gelatinous or semi-solidified carrier.
Claim 19
Independent Claim
48 words
A method of preparing a biocompatible and non-antigenic bone grafting material from allogenic or xenogenic bone stock, comprising: (a) pulverizing a bone segment to obtain pulverized bone; (b) tanning the pulverized bone with glutaraldehyde under tanning conditions; (c) combining the pulverized bone with a gelatinous or semi-solidified carrier.
Claim 20
Dependent Claim
17 words
The method of claim 17, additionally comprising treating the bone with a protease to increase matrix porosity.
Claim 21
Dependent Claim
20 words
The method of claim 17 or 18, additionally comprising extracting the bone with an organic solvent to increase matrix porosity.
Claim 22
Dependent Claim
12 words
The method of claim 17 additionally comprising sterilizing the bone grafting material.
Claim 23
Dependent Claim
17 words
The method of claim 17 additionally comprising removing fats and machining oils from the bone with ethanol.
Claim 24
Dependent Claim
10 words
The method of claim 17 additionally comprising demineralizing the bone.
Claim 25
Dependent Claim
25 words
A biocompatible, non-antigenic and stable bone-grafting material comprising allogenic or xenogenic bone stock machined to a desired shape and tanned with glutaraldehyde under tanning conditions.
Claim 26
Dependent Claim
25 words
A biocompatible, non-antigenic and stable bone-grafting material comprising allogenic or xenogenic bone stock machined to a desired shape and tanned with glutaraldehyde under tanning conditions.
Claim 27
Dependent Claim
26 words
A biocompatible, non-antigenic, and stable bone-grafting material comprising allogenic or xenogenic bone stock that has been pulverized or powdered and tanned with glutaraldehyde under tanning conditions.
Claim 28
Dependent Claim
26 words
A biocompatible, non-antigenic, and stable bone-grafting material comprising allogenic or xenogenic bone stock that has been pulverized or powdered and tanned with glutaraldehyde under tanning conditions.
Claim 29
Dependent Claim
18 words
The bone grafting material of claims 23 or 24 which exhibits osteoconduction when implanted adjacent to host bone.
Claim 30
Independent Claim
35 words
A method of repairing bone defects comprising (a) removing damaged or diseased host bone portions that may be present; and (b) implanting the bone grafting material of claims 23 or 24 to repair the defect.
Claim 31
Dependent Claim
31 words
The method of claim 1 wherein the bone segment is contacted with a buffered tanning solution comprising about 0.2% to about 0.8% (w/v) glutaraldehyde for a minimum of about one month.
References Cited (Backward Citations)
US4120730A
Cited
US4309488A
Cited
US4277238A
Cited
US4257405A
Cited
US4330891A
Cited
US4349470A
Cited
US4394370A
Cited
US4472840A
Cited
US4440750A
Cited
US4485096A
Cited
US4407793A
Cited
US4485097A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-06 | 1991-01-05 | 1991-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-06 | 1995-01-05 | 1995-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-06 | 1999-01-05 | 1999-07-07 | $7700.00 | Window Closed / Lapsed |