US5356629A
Expired / Lapsed
US
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Composition for effecting bone repair
Assignee: United States Surgical Corp
•
Filing: 1991-07-12
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Granted: 1994-10-18
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Expires: 2011-07-12
Abstract
Abstract A composition for effecting bone repair is provided which includes biocompatible particles dispersed in a matrix.
Inventors
- 👤 Thomas W. Sander
- 👤 Donald S. Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:29
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
127 words
A composition suitable to effect bone repair comprising from about 64 to about 94% by weight of biocompatible particles dispersed in from about 6 to about 36% by weight of a matrix selected from the group consisting of cellulose ether, collagen, hyaluronic acid, pharmaceutically acceptable salt of hyaluronic acid, ester of hyaluronic acid and pharmaceutically acceptable salt of hyaluronic acid ester and mixtures thereof to provide a measured stiffness of about 0.01 lb/in to about 10 lb/in when wetted with liquid medium, wherein said biocompatible particles are formed from polymethylmethacrylate coated with polyhydroxyethylmethacrylate, whereby said composition, when wetted, forms a moldable semi-solid mass which can be suitably worked for implantation into bone and will remain in moldable semi-solid form as long as not permitted to dry out.
Claim 2
Dependent Claim
127 words
A composition suitable to effect bone repair comprising from about 64 to about 94% by weight of biocompatible particles dispersed in from about 6 to about 36% by weight of a matrix selected from the group consisting of cellulose ether, collagen, hyaluronic acid, pharmaceutically acceptable salt of hyaluronic acid, ester of hyaluronic acid and pharmaceutically acceptable salt of hyaluronic acid ester and mixtures thereof to provide a measured stiffness of about 0.01 lb/in to about 10 lb/in when wetted with liquid medium, wherein said biocompatible particles are formed from polymethylmethacrylate coated with polyhydroxyethylmethacrylate, whereby said composition, when wetted, forms a moldable semi-solid mass which can be suitably worked for implantation into bone and will remain in moldable semi-solid form as long as not permitted to dry out.
Claim 3
Dependent Claim
28 words
The composition of claim 1 comprising from about 8% to about 27% by weight of said matrix and about 73% to about 92% by weight of said particles.
Claim 4
Dependent Claim
28 words
The composition of claim 2 comprising from about 10% to about 18% by weight of said matrix and about 82% to about 90% by weight of said particles.
Claim 5
Dependent Claim
28 words
The composition of claim 1 additionally comprising at least one ingredient selected from the group consisting of antimicrobial agents, growth promoting factor and osteogenic agent and mixtures thereof.
Claim 6
Dependent Claim
19 words
The composition of claim 1 having a measured stiffness of about 0.05 lb/in to about 5 lb/in when wetted.
Claim 7
Dependent Claim
19 words
The composition of claim 5 having a measured stiffness of about 0.1 lb/in to about 3.0 lb/in when wetted.
Claim 8
Dependent Claim
9 words
The composition of claim 1 being in moldable form.
Claim 9
Dependent Claim
11 words
The composition of claim 1 wherein the liquid medium contains water.
Claim 10
Dependent Claim
22 words
The composition or claim 1, additionally comprising about 5% to about 60% by weight of wetting liquid medium in the total composition.
Claim 11
Dependent Claim
135 words
A wetted composition suitable for effecting bone repair, comprising (i) about 5 to about 60% by weight of wetting liquid medium, (ii) about 75 to about 35 % by weight of biocompatible particles of polymethylmethacrylate coated with polyhydroxyethylmethacylate, and (iii) about 5 to about 20% by weight of a matrix selected from the group consisting of cellulose ether, collagen, hyaluronic acid, pharmaceutically acceptable salt of hyaluronic acid, ester of hyaluronic acid, pharmaceutically acceptable of hyaluronic acid ester and mixtures thereof, the biocompatible particles (ii) being dispersed in the matrix (iii), said composition having a measured stiffness of about 0.01 lb/in to about 10 lb/in, whereby said composition forms a moldable semi-solid mass which can be suitably worked for implantation into bone and will remain in semi-solid form as long as not permitted to dry out.
Claim 12
Dependent Claim
135 words
A wetted composition suitable for effecting bone repair, comprising (i) about 5 to about 60% by weight of wetting liquid medium, (ii) about 75 to about 35 % by weight of biocompatible particles of polymethylmethacrylate coated with polyhydroxyethylmethacylate, and (iii) about 5 to about 20% by weight of a matrix selected from the group consisting of cellulose ether, collagen, hyaluronic acid, pharmaceutically acceptable salt of hyaluronic acid, ester of hyaluronic acid, pharmaceutically acceptable of hyaluronic acid ester and mixtures thereof, the biocompatible particles (ii) being dispersed in the matrix (iii), said composition having a measured stiffness of about 0.01 lb/in to about 10 lb/in, whereby said composition forms a moldable semi-solid mass which can be suitably worked for implantation into bone and will remain in semi-solid form as long as not permitted to dry out.
Claim 13
Dependent Claim
42 words
The composition of claim 10 comprising (i) about 15 to about 54% by weight of the wetting liquid medium, (ii) about 70 to about 40% by weight of the particles, and (iii) about 6 to about 15% by weight of the matrix.
Claim 14
Dependent Claim
43 words
The composition of claim 11 comprising (i) from about 30 to about 48% by weight of the wetting liquid medium, (ii) about 60 to about 45% by weight of the particles, and (iii) about 7% to about 10% by weight of the matrix.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-17 | 1998-04-18 | 1998-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-17 | 2002-04-18 | 2002-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-17 | 2006-04-18 | 2006-10-18 | $7700.00 | Window Closed / Lapsed |