US6436138B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing flexible sheets from demineralized, elongate, bone particles
Assignee: Warsaw Orthopedic Inc
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Filing: 1997-01-16
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Granted: 2002-08-20
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Expires: 2017-01-16
Abstract
Abstract A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid form the demineralized bone particles to provide a cohering shaped mass of demineralized bone particles, and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period. The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.
Inventors
- 👤 Michael Dowd
- 👤 Nelson L. Scarborough
- 👤 Mark Daugherty
- 👤 Jack McMickle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:48
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/46; A61F2/4644; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3687; A61F2/3094; A61F2/30942; A61F2002/30957; A61F2002/4649; A61L2430/00; A61L2430/02; A61L2430/40; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
83 words
A process for fabricating shaped material from bone particles, comprising the steps of: applying a liquid slurry of bone particles to a support; removing excess liquid from the slurry of bone particles to provide a coherent shaped mass of bone particles; warming the shaped-mass of bone particles at a predetermined temperature and for a predetermined time period to improve cohesive properties of the shaped-mass of bone particles; and subjecting the shaped-mass of demineralized bone particles to lyophilization subsequent to the step of warming.
Claim 2
Dependent Claim
83 words
A process for fabricating shaped material from bone particles, comprising the steps of: applying a liquid slurry of bone particles to a support; removing excess liquid from the slurry of bone particles to provide a coherent shaped mass of bone particles; warming the shaped-mass of bone particles at a predetermined temperature and for a predetermined time period to improve cohesive properties of the shaped-mass of bone particles; and subjecting the shaped-mass of demineralized bone particles to lyophilization subsequent to the step of warming.
Claim 3
Dependent Claim
20 words
The process according to claim 1 wherein the step of applying includes applying a liquid slurry comprises demineralized bone particles.
Claim 4
Dependent Claim
23 words
The process according to claim 2 further including the step of compressing the shaped-mass of demineralized bone particles during the step of warming.
Claim 5
Dependent Claim
32 words
The process according to claim 2 wherein the step of applying includes pouring the liquid slurry of demineralized bone particles onto a porous support to provide a sheet of demineralized bone particles.
Claim 6
Dependent Claim
25 words
The process according to claim 4 further including the step of positioning the sheet of demineralized bone particles into a correspondingly dimensioned porous mold support.
Claim 7
Dependent Claim
27 words
The process according to claim 5 wherein the step of warming includes placing the mold support and the sheet of demineralized bone particles into a heating device.
Claim 8
Dependent Claim
48 words
The process according to claim 2 wherein the step of applying includes applying a liquid slurry of demineralized bone particles, wherein the bone particles are selected from the group consisting of cortical, cancellous and corticocancellous bone, and wherein the bone particles have an autogenous, allogenic or xenogeneic origin.
Claim 9
Dependent Claim
46 words
The process according to claim 2 wherein the step of warming includes subjecting the shaped mass of demineralized bone particles to a temperature ranging from about 22° C. to about 55° C. for a period of time ranging from about 2 hours to about 4 hours.
Claim 10
Dependent Claim
35 words
The process according to claim 8 wherein the step of warming includes subjecting the shaped mass of demineralized bone particles to a temperature of about 45° C. for a period of time about 3 hours.
Claim 11
Dependent Claim
28 words
The process according to claim 9 wherein the step of lyophilizing further includes positioning the sheet of demineralized bone particles disposed in the mold within a lyophilization chamber.
Claim 12
Dependent Claim
24 words
The process according to claim 9 further including the step of compressing the sheet of demineralized bone particles while subjecting the sheet to heat.
Claim 13
Dependent Claim
34 words
The process according to claim 11 , wherein the step of compressing includes placing a compressive cover on to the mold to apply compressive forces to the sheet of demineralized bone particles disposed therein.
Claim 14
Independent Claim
69 words
A method for treating a shaped-mass of demineralized bone particles, comprising the steps of: heating a shaped-mass of demineralized bone particles; and subsequently lyophilizing the shaped-mass of demineralized bone particles; wherein, during the step of heating, the shaped-mass of demineralized bone particles are subjected to an elevated temperature for a predetermined period of time sufficient to improve the cohesive characteristics of the shaped-mass of bone particles upon lyophilization thereof.
Claim 15
Independent Claim
69 words
A method for treating a shaped-mass of demineralized bone particles, comprising the steps of: heating a shaped-mass of demineralized bone particles; and subsequently lyophilizing the shaped-mass of demineralized bone particles; wherein, during the step of heating, the shaped-mass of demineralized bone particles are subjected to an elevated temperature for a predetermined period of time sufficient to improve the cohesive characteristics of the shaped-mass of bone particles upon lyophilization thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-08-19 | 2006-02-18 | 2006-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-08-19 | 2010-02-18 | 2010-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-08-19 | 2014-02-18 | 2014-08-20 | $7700.00 | Window Closed / Lapsed |