US4440750A
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Osteogenic composition and method
Assignee: Harvard University
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Filing: 1982-02-12
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Granted: 1984-04-03
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Expires: 2002-02-12
Abstract
Abstract A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction site. Once emplaced the dispersion induces rapid and complete osteogenesis at the site.
Inventors
- 👤 Julianne Glowacki
- 👤 Bruce B. Pharriss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/14; A61L27/22; A61L27/24; A61L27/3641; A61L27/3645; A61L27/365; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
29 words
An osteogenic composition comprising a plastic dispersion of particulate demineralized bone and reconstituted collagen fibers dispersed in a continuous aqueous phase having a substantially physiological pH and ionic strength.
Claim 2
Dependent Claim
29 words
An osteogenic composition comprising a plastic dispersion of particulate demineralized bone and reconstituted collagen fibers dispersed in a continuous aqueous phase having a substantially physiological pH and ionic strength.
Claim 3
Dependent Claim
12 words
The osteogenic composition of claim 1 wherein the collagen is atelopeptide collagen.
Claim 4
Dependent Claim
41 words
The osteogenic composition of claim 1 or 2 wherein the demineralized bone constitutes about 10% to about 70% by weight of the dispersed phase and the reconstituted collagen fibers constitute about 30% to about 90% by weight of the dispersed phase.
Claim 5
Dependent Claim
27 words
The osteogenic composition of claim 1, 2 or 3 wherein the demineralized bone has a particle size in the range of about 25 to about 1000 microns.
Claim 6
Dependent Claim
24 words
The osteogenic composition of claim 1 or 2 wherein the demineralized bone has a particle size in the range of 75 to 250 microns.
Claim 7
Dependent Claim
23 words
The osteogenic composition of claim 1 or 2 wherein the dispersed phase constitutes about 20% to about 60% by weight of the dispersion.
Claim 8
Dependent Claim
30 words
The composition of claim 1 or 2 wherein the pH is in the range of 6.8 to 7.5 and the ionic strength is in the range of 0.1 to 0.2.
Claim 9
Dependent Claim
27 words
The composition of claim 1 or 2 wherein the source of the demineralized bone is bovine long bone and the source of the collagen is bovine corium.
Claim 10
Dependent Claim
18 words
The osteogenic composition of claim 1 wherein the plastic dispersion is in the form of an injectable fluid.
Claim 11
Dependent Claim
19 words
The osteogenic composition of claim 1 wherein the plastic dispersion is in the form of a substantially nonfluid semisolid.
Claim 12
Independent Claim
41 words
A method for inducing osteogenesis at a site within a living vertebrate comprising emplacing a plastic dispersion of particulate demineralized bone and reconstituted collagen fibers in a continuous aqueous phase having a substantially physiological pH and ionic strength at said site.
Claim 13
Independent Claim
41 words
A method for inducing osteogenesis at a site within a living vertebrate comprising emplacing a plastic dispersion of particulate demineralized bone and reconstituted collagen fibers in a continuous aqueous phase having a substantially physiological pH and ionic strength at said site.
Claim 14
Dependent Claim
54 words
The method of claim 11 wherein the demineralized bone powder constitutes about 10% to about 70% by weight of the dispersed phase and the reconstituted collagen fibers constitute about 30% to about 90% by weight of the dispersed phase and the dispersed phase constitutes about 20% to about 60% by weight of the dispersion.
Claim 15
Dependent Claim
13 words
The method of claim 11 or 12 wherein the collagen is atelopeptide collagen.
Claim 16
Dependent Claim
22 words
The method of claim 13 wherein the demineralized bone has a particle size in the range of about 75 to 250 microns.
Claim 17
Dependent Claim
28 words
The method of claim 13 wherein the pH is in the range of 6.8 to 7.5 and the ionic strength is in the range of 0.1 to 0.2.
Claim 18
Dependent Claim
22 words
The method of claim 13 wherein the vertebrate is a human and the sources of the bone and the collagen are xenogeneic.
Claim 19
Dependent Claim
27 words
The method of claim 13 wherein the plastic dispersion is in the form of an injectable fluid and the emplacement of the dispersion is effected by injection.
Claim 20
Dependent Claim
29 words
The method of claim 13 wherein the plastic dispersion is in the form of a substantially nonfluid semisolid and the emplacement of the dispersion is effected by surgical implantation.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-03 | 1987-10-03 | 1988-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-03 | 1991-10-03 | 1992-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-03 | 1995-10-03 | 1996-04-03 | $7700.00 | Window Closed / Lapsed |