Shaped materials derived from elongate bone particles

Claim 2

A shaped material comprising a coherent mass of elongate, mechanically entangled demineralized bone particles wherein at least about 60 weight percent of the bone particles possess a median length of from about 10 mm to about 100 mm, a median thickness of from about 0.02 mm to about 1 mm and a median width of from about 2 mm to about 5 mm.

Claim 3

The shaped material of claim 1 exhibiting osteogenic activity.

Claim 4

The shaped material of claim 1 wherein the bone particles are obtained from cortical, cancellous and corticocancellous bone of autogenous allogenic and xenogenic origin.

Claim 5

The shaped material of claim 1 wherein the bone particles are obtained from porcine bone.

Claim 6

The shaped material of claim 1 further comprising one or more additives selected from the group consisting of plasticizers, flexibilizing agents, biostatic agents, biocidal agents, surface active agents, binding and bonding agents and fillers.

Claim 7

The shaped material of claim 1 further comprising at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, inorganic element, protein synthesis co-factor, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, demineralized bone powder, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal stem cells, bone digester, antitumor agent, cellular attractant, fibronectin, growth hormone cellular attachment agent, immunosuppressant, nucleic acid, hydroxy apatite and penetration enhancer.

Claim 8

The shaped material of claim 1 in the form of a flat sheet, curved sheet, plate, disk, cone, pin, screw or tube.

Claim 9

A shaped material comprising a coherent mass of elongate, mechanically entangled demineralized bone particles wherein at least about 60 weight percent of the bone particles possess a median length to median thickness ratio of from about 50:1 to about 500:1 and a median length to median width ratio of from about 10:1 to about 200:1.

Claim 10

A shaped material comprising a coherent mass of elongate, mechanically entangled demineralized bone particles wherein at least about 60 weight percent of the bone particles possess a median length to median thickness ratio of from about 50:1 to about 500:1 and a median length to median width ratio of from about 10:1 to about 200:1.

Claim 11

The shaped material of claim 8 exhibiting osteogenic activity.

Claim 12

The shaped material of claim 8 wherein the bone particles are obtained from cortical, cancellous and corticocancellous bone of autogenous allogenic and xenogenic origin.

Claim 13

The shaped material of claim 8 wherein the bone particles are obtained from porcine bone.

Claim 14

The shaped material of claim 8 further comprising one or more additives selected from the group consisting of plasticizers, flexibilizing agents, biostatic agents, biocidal agents, surface active agents, binding and bonding agents and fillers.

Claim 15

The shaped material of claim 8 further comprising at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, inorganic element, protein synthesis cofactor, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, demineralized bone powder, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal stem cells, bone digester, antitumor agent, cellular attractant, fibronectin, growth hormone cellular attachment agent, immunosuppressant, nucleic acid, hydroxy apatite and penetration enhancer.

Claim 16

The shaped material of claim 1 in the form of a flat sheet, curved sheet, plate, disk, cone, pin, screw or tube.

Claim 17

A shaped material comprising a coherent mass of elongate, mechanically entangled, demineralized bone particles wherein at least about 60 weight percent of the bone particles possess a median length to median thickness ratio of from about 50:1 to about 100:1 and a median length to median width ratio of from about 50:1 to about 100:1.

Claim 18

A shaped material comprising a coherent mass of elongate, mechanically entangled, demineralized bone particles wherein at least about 60 weight percent of the bone particles possess a median length to median thickness ratio of from about 50:1 to about 100:1 and a median length to median width ratio of from about 50:1 to about 100:1.

Claim 19

The shaped material of claim 15 exhibiting osteogenic activity.

Claim 20

The shaped material of claim 15 wherein the bone particles are obtained from cortical, cancellous and corticocancellous bone of autogenous allogenic and xenogenic origin.

Claim 21

The shaped material of claim 15 wherein the bone particles are obtained from porcine bone.

Claim 22

The shaped material of claim 15 further comprising one or more additives selected from the group consisting of plasticizers, flexibilizing agents, biostatic agents, biocidal agents, surface active agents, binding and bonding agents and fillers.

Claim 23

The shaped material of claim 15 further comprising at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, inorganic element, protein synthesis cofactor, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, demineralized bone powder, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal stem cells, bone digester, antitumor agent, cellular attractant, fibronectin, growth hormone cellular attachment agent, immunosuppressant, nucleic acid, hydroxy apatite and penetration enhancer.

Claim 24

The shaped material of claim 15 in the form of a flat sheet, curved sheet, plate, disk, cone, pin, screw or tube.