US5573771A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicinal bone mineral products
Assignee: Ed Geistlich Soehne AG fuer Chemische Industrie
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Filing: 1995-02-21
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Granted: 1996-11-12
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Expires: 2015-02-21
Abstract
Abstract The invention provides a purified particulate bone mineral product for use in medicine, the particles of said mineral being substantially free from all endogenous organic material and having at least at the surface thereof resorbable, physiologically compatible, natural or synthetic macromolecular material. In particular the invention provides a bone mineral impregnated with a gel-forming protein or polysaccharide such as gelatin to provide a surprising increase in strength and a product comprising bone mineral in a matrix of collagen-fibres and a gel-forming protein. Such products are intended as remodeling implants or prosthetic bone replacement.
Inventors
- 👤 Peter Geistlich
- 👤 Rolf W. Pfirrmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61L27/446; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/40; A61L2300/412; A61L2300/414; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/919; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
90 words
A particulate bone mineral product for use in medicine comprising porous bone mineral particles derived from natural bone having a crystal structure of natural bone and substantially free from all endogenous organic material, the particles having an average diameter in the range of 0.1 to 10 mm, and having at least at the surface thereof resorbable, physiologically compatible, collagen fibers in an amount which increases the strength of the bone mineral particles wherein the weight ratio of said collagen fibers to said porous bone mineral particles is at least 1:20'.
Claim 2
Dependent Claim
90 words
A particulate bone mineral product for use in medicine comprising porous bone mineral particles derived from natural bone having a crystal structure of natural bone and substantially free from all endogenous organic material, the particles having an average diameter in the range of 0.1 to 10 mm, and having at least at the surface thereof resorbable, physiologically compatible, collagen fibers in an amount which increases the strength of the bone mineral particles wherein the weight ratio of said collagen fibers to said porous bone mineral particles is at least 1:20'.
Claim 3
Dependent Claim
36 words
A product as claimed in claim 1 in which the bone mineral is prepared by completely de-greasing particulate bone and treating it with ammonia or an amine to degrade residual protein followed by extensive water washing.
Claim 4
Dependent Claim
17 words
A product as claimed in claim 1 which further comprises at least one absorbed pharmaceutically active substance.
Claim 5
Dependent Claim
17 words
A product as claimed in claim 3 in which said pharmaceutically active substance is taurolidine or taurultam.
Claim 6
Dependent Claim
35 words
A product as claimed in claim 3 in which said physiologically active substance is capable of assisting bone regeneration and is selected from morphogenic growth factors, angiogenic growth factors, transforming growth factors, ossein, and osteopoietin.
Claim 7
Dependent Claim
28 words
A method of treatment of a human or animal subject wherein a bone mineral product as claimed in claim 1 is used as a remodelling implant or prosthesis.
Claim 8
Dependent Claim
28 words
A product as claimed in claim 1 in which the weight ratio of the collagen fibers to the bone material is in the range of 1:20 to 3:20.
Claim 9
Dependent Claim
39 words
A product as claimed in claim 1, further comprising gelatin in a gel phase, wherein said collagen fibers are present in said gel phase, and wherein said gel phase comprises 2 to 8% by weight of the bone material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-11-12 | 2000-05-13 | 2000-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-12 | 2004-05-13 | 2004-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-12 | 2008-05-13 | 2008-11-12 | $7700.00 | Window Closed / Lapsed |