US4795467A
Expired / Lapsed
US
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Xenogeneic collagen/mineral preparations in bone repair
Assignee: Neucoll Inc
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Filing: 1986-04-04
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Granted: 1989-01-03
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Expires: 2006-04-04
Abstract
Abstract A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.
Inventors
- 👤 Karl A. Piez
- 👤 Bruce B. Pharriss
- 👤 George H. Chu
- 👤 Thomas L. Smestad
- 👤 Diana Hendricks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:42
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2835; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
41 words
A composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component obtained from mineral particles of non-biological origin in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen.
Claim 2
Dependent Claim
41 words
A composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component obtained from mineral particles of non-biological origin in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen.
Claim 3
Dependent Claim
29 words
The composition of claim 1 wherein the mineral component is selected from the group consisting of hydroxyapatite, tricalcium phosphate, and mixtures thereof, and wherein the particles are 100-2000 μm.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein the collagen is supplied as an aqueous suspension of 35 mg/ml-65 mg/ml.
Claim 5
Dependent Claim
13 words
The composition of claim 1 which contains less than 1% by weight water.
Claim 6
Dependent Claim
20 words
A method of repairing bone which comprises placing in contact with a fresh bone surface the composition of claim 1.
Claim 7
Dependent Claim
59 words
A process for preparing a composition for use in bone repair, which process comprises subjecting a dried mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen component, said mixture containing less than 1% by weight water, to a temperature of 60°-120° C. for 4-168 hours.
Claim 8
Dependent Claim
59 words
A process for preparing a composition for use in bone repair, which process comprises subjecting a dried mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen component, said mixture containing less than 1% by weight water, to a temperature of 60°-120° C. for 4-168 hours.
Claim 9
Dependent Claim
16 words
The process of claim 6 wherein the mixture is treated at 75°-90° C. for 6-72 hours.
Claim 10
Dependent Claim
12 words
A composition which is the product of the process of claim 6.
Claim 11
Dependent Claim
70 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting of essentially 60-98% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises incubating said mixture in the presence of water at approximately 37° C. for 1-10 days, followed by drying said mixture to a moisture content of less than 1% by weight.
Claim 12
Dependent Claim
70 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting of essentially 60-98% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises incubating said mixture in the presence of water at approximately 37° C. for 1-10 days, followed by drying said mixture to a moisture content of less than 1% by weight.
Claim 13
Dependent Claim
12 words
A composition which is the product of the process of claim 9.
Claim 14
Dependent Claim
21 words
The process of claim 9 which further includes subjecting the dried, mixture to a temperature of 60°-120° C. for 4-168 hours.
Claim 15
Dependent Claim
12 words
A composition which is the product of the process of claim 11.
Claim 16
Dependent Claim
85 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-90% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises exposing said mixture in the presence of water to the vapors of a cross-linking agent for a time and at a temperature effective to effect cross-linking of the collagen component, followed by drying said mixture to a moisture content of less than 1% by weight.
Claim 17
Dependent Claim
85 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-90% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises exposing said mixture in the presence of water to the vapors of a cross-linking agent for a time and at a temperature effective to effect cross-linking of the collagen component, followed by drying said mixture to a moisture content of less than 1% by weight.
Claim 18
Dependent Claim
19 words
The process of claim 13 wherein the mixture is exposed to cross-linking agent at 37° C. for 1-10 days.
Claim 19
Dependent Claim
11 words
The process of claim 14 wherein the cross-linking agent is glutaraldehyde.
Claim 20
Dependent Claim
12 words
A composition for bone repair prepared by the process of claim 13.
Claim 21
Dependent Claim
21 words
The process of claim 13 which further includes subjecting the dried mixture to a temperature of 60°-120° C. for 4-168 hours.
Claim 22
Dependent Claim
12 words
A composition for bone repair prepared by the process of claim 17.
Claim 23
Dependent Claim
68 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises soaking said mixture in a solution containing cross-linking agent removing said cross-linking agent, and drying the mixture to a moisture content of less than 1% by weight.
Claim 24
Dependent Claim
68 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process comprises soaking said mixture in a solution containing cross-linking agent removing said cross-linking agent, and drying the mixture to a moisture content of less than 1% by weight.
Claim 25
Dependent Claim
20 words
The process of claim 19 wherein the cross-linking agent is selected from glutaraldehyde and formaldehyde at a concentration of 0.001-1.0%.
Claim 26
Dependent Claim
12 words
A composition for bone repair prepared by the process of claim 19.
Claim 27
Dependent Claim
21 words
The process of claim 19 which further includes subjecting the dried mixture to a temperature of 60°-120° C. for 4-168 hours.
Claim 28
Dependent Claim
12 words
A composition for bone repair prepared by the process of claim 22.
Claim 29
Dependent Claim
79 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with of an atelopeptide reconstituted fibrillar collagen, which process comprises drying the mixture to a moisture content of less than 1% by weight, then soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and redrying the mixture to a moisture content of less than 1%.
Claim 30
Dependent Claim
79 words
A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with of an atelopeptide reconstituted fibrillar collagen, which process comprises drying the mixture to a moisture content of less than 1% by weight, then soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and redrying the mixture to a moisture content of less than 1%.
Claim 31
Dependent Claim
12 words
A composition for bone repair prepared by the process of claim 24.
Claim 32
Dependent Claim
18 words
A process for augmentation of bone defects which comprises applying to said defect the composition of claim 1.
Claim 33
Dependent Claim
11 words
The process of claim 26 wherein the bone defect is periodontal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-03 | 1992-07-04 | 1993-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-03 | 1996-07-04 | 1997-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-03 | 2000-07-04 | 2001-01-03 | $7700.00 | Window Closed / Lapsed |