US4627853A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of producing prostheses for replacement of articular cartilage and prostheses so produced
Assignee: Baxter International Inc
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Filing: 1985-05-29
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Granted: 1986-12-09
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Expires: 2005-05-29
Abstract
Abstract Prostheses useful for articulating cartilage replacement, and which are attached to host bone without the use of cements, are derived from bone. Allogenic or xenogenic bone segments are machined into the desired shape and differentially demineralized. The completely demineralized portion has a spongy texture similar to natural cartilage, while the non-demineralized portion is a matrix into which adjacent host bone grows, thus anchoring the prosthesis. The prostheses are tanned which renders the material non-antigenic, biocompatible, and stable.
Inventors
- 👤 Todd D. Campbell
- 👤 Aws S. Nashef
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:55
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/30756; A61F2/32; A61F2/36; A61F2/3601; A61F2/3603; A61F2/38; A61K; A61K35/00; A61K35/12; A61K35/32; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/3654; A61L27/3683; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61F2/46; A61F2/4644; A61F2002/2825; A61F2002/2828; A61F2002/2835; A61F2002/2839; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2002/30108; A61F2002/30199; A61F2002/30205; A61F2002/30316; A61F2002/30535; A61F2002/30563; A61F2/3094; A61F2/30942; A61F2002/30957; A61F2002/30971; A61F2230/00; A61F2230/0063; A61F2230/0067; Y; Y10; Y10S; Y10S623/00; Y10S623/902; Y10S623/908
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
74 words
A method of producing a prosthesis for replacing articular cartilage comprising: (a) machining a bone segment into a desired shape, (b) differentially demineralizing said bone segment to produce both demineralized and non-demineralized portions of said bone segment, such that demineralized portion has a spongy texture similar to natural cartilage, and the non-demineralized portion is a matrix into which adjacent host bone grows, (c) tanning said bone segment to render it non-antigenic, biocompatible and stable.
Claim 2
Independent Claim
74 words
A method of producing a prosthesis for replacing articular cartilage comprising: (a) machining a bone segment into a desired shape, (b) differentially demineralizing said bone segment to produce both demineralized and non-demineralized portions of said bone segment, such that demineralized portion has a spongy texture similar to natural cartilage, and the non-demineralized portion is a matrix into which adjacent host bone grows, (c) tanning said bone segment to render it non-antigenic, biocompatible and stable.
Claim 3
Dependent Claim
19 words
The method of claim 1 additionally comprising extracting the bone segment with an organic solvent to increase matrix porosity.
Claim 4
Independent Claim
21 words
The method of claims 1 or 2 additionally comprising treating the bone segment with a protease to increase the matrix porosity.
Claim 5
Independent Claim
16 words
The method of claims 1, or 2 additionally comprising a final step of sterilizing the prosthesis.
Claim 6
Dependent Claim
16 words
The method of claim 1, wherein the bone segment is tanned with glutaraldehyde under tanning conditions.
Claim 7
Dependent Claim
59 words
The method of claim 1, wherein the bone segment is differentially demineralized by (a) immersing one portion of the bone segment in a demineralizing solution, (b) immersing the remaining portion in a non-demineralizing solution such that positive pressure exerted by diffusion of the non-demineralizing solution into the bone segment keeps the demineralizing solution from diffusing throughout the bone segment.
Claim 8
Dependent Claim
26 words
The method of claim 1, wherein a portion or the bone segment is demineralized by contacting said bone segment with a demineralizing solution comprising an acid.
Claim 9
Dependent Claim
12 words
The method of claim 7 wherein said demineralizing solution additionally comprises EDTA.
Claim 10
Dependent Claim
24 words
The method of claim 1 which additionally comprises submerging the bone segment in ethanolto surface defat it and to remove machine oils and debris.
Claim 11
Dependent Claim
29 words
The method of claim 1 wherein the bone segment is derived from the condylar region of an allogenic or xenogenic bone comprising bovine, porcine, ovine, or equine long bone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-08 | 1990-06-09 | 1990-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-08 | 1994-06-09 | 1994-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-08 | 1998-06-09 | 1998-12-09 | $7700.00 | Window Closed / Lapsed |