US6387978B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
Assignee: Boston Scientific Corp
•
Filing: 2001-01-08
•
Granted: 2002-05-14
•
Expires: 2021-01-08
Abstract
Abstract Shaped-medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices comprise shaped polymeric hydrogels which are both ionically and non-ionically crosslinked and which exhibit improved structural integrity after selective removal of the crosslinking ions. Process for making such devices are also disclosed wherein an ionically crosslinkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the crosslinking ions produces a softer, more flexible implant having improved structural integrity.
Inventors
- 👤 John M. Ronan
- 👤 Samuel A. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:05
CPC Classifications
A; A61; A61M; A61M27/00; A61M27/002; A61M27/008; A61L; A61L29/00; A61L29/14; A61L29/145; A61L31/00; A61L31/14; A61L31/145; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0084; C08J; C08J3/00; C08J3/24; C08J3/243; A61F; A61F2/00; A61F2/82; C08J2300/00; C08J2300/14; Y; Y10; Y10S; Y10S524/00; Y10S524/916; Y10S525/00; Y10S525/903; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
63 words
A shaped medical device having improved mechanical properties comprising a crosslinked polymeric hydrogel, said hydrogel comprising both an ionic and a non-ionic crosslink structure, wherein said shaped medical device having a first shape and a second shape whereby said shaped medical device changes from said first shape to said second shape upon selective and at least partial removal of said ionic crosslink structure.
Claim 2
Dependent Claim
63 words
A shaped medical device having improved mechanical properties comprising a crosslinked polymeric hydrogel, said hydrogel comprising both an ionic and a non-ionic crosslink structure, wherein said shaped medical device having a first shape and a second shape whereby said shaped medical device changes from said first shape to said second shape upon selective and at least partial removal of said ionic crosslink structure.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein said non-ionic crosslink structure is a covalent crosslink structure.
Claim 4
Dependent Claim
22 words
The device of claim 1 wherein, upon selective removal of the ionic crosslinks, said device reconfigures substantially to the non-ionically crosslinked shape.
Claim 5
Dependent Claim
75 words
The device of claim 1 wherein said hydrogel comprises one or a mixture of polymers selected from the group consisting of polyhydroxy ethyl methacrylate, polyvinyl alcohol, polyacrylamide, poly(N-vinyl pyrrolidone), polyethylene oxide, hydrolysed polyacrylonitrile, polyacrylic acid, polymethacrylic acid, polyethylene amine, alginic acid, pectinic acid, carboxy methyl cellulose, hyaluronic acid, heparin, heparin sulfate, chitosan, carboxymethyl chitosan, chitin, pullulan, gellan, xanthan, carboxymethyl starch, carboxymethyl dextran, chondroitin sulfate, cationic guar, cationic starch as well as salts and esters thereof.
Claim 6
Dependent Claim
33 words
The device of claim 1 wherein said hydrogel comprises an anionic polymer and cations selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, lead and silver ions.
Claim 7
Dependent Claim
29 words
The device of claim 1 wherein said hydrogel comprises a cationic polymer and anions selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 8
Dependent Claim
30 words
The device of claim 1 wherein said hydrogel comprises one or a mixture of cationic polymers selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 9
Dependent Claim
47 words
The device of claim 1 wherein said non-ionic crosslink structure is formed by contacting said ionically crosslinkable polymer under reaction conditions with a crosslinking agent having at least two functional groups reactive with one or more functional groups present in said hydrogel polymer to form covalent bonds.
Claim 10
Dependent Claim
18 words
The device of claim 8 wherein said crosslinking agent contains carboxyl, hydroxy, epoxy, halogen or amino functional groups.
Claim 11
Dependent Claim
21 words
The device of claim 8 wherein said crosslinking agent is selected from the group consisting of glutaraldehyde, epichlorohydrin, dianhydrides and diamines.
Claim 12
Dependent Claim
11 words
The device of claim 10 wherein said crosslinking agent is glutaraldehyde.
Claim 13
Dependent Claim
37 words
The device of claim 1 wherein said hydrogel comprises a polymer selected from the group consisting of one or a mixture of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid, chitosan, polyvinylalcohol, and salts and esters thereof.
Claim 14
Dependent Claim
11 words
The device of claim 12 wherein said hydrogel comprises alginic acid.
Claim 15
Dependent Claim
23 words
The device of claim 12 wherein said hydrogel is an ester of alginic acid and a C 2 to C 4 alkylene glycol.
Claim 16
Dependent Claim
12 words
The device of claim 14 wherein said alkylene glycol is propylene glycol.
Claim 17
Dependent Claim
18 words
The device of claim 12 wherein said hydrogel comprises a mixture of alginic or pectinic acid and polyvinylalcohol.
Claim 18
Dependent Claim
13 words
The device of claim 1 in the shape of a cylindrical, hollow tube.
Claim 19
Dependent Claim
27 words
The device of claim 1 wherein said shaped medical device is selected from the group consisting of stents, catheters, cannulas, plugs, constrictors, and tissue and biological encapsulants.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-05-13 | 2005-11-12 | 2006-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-05-13 | 2009-11-12 | 2010-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-05-13 | 2013-11-12 | 2014-05-14 | $7700.00 | Window Closed / Lapsed |