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US5202431A Expired / Lapsed US ⏱️ 0.0 years remaining

Partial esters of hyaluronic acid

Assignee: Fidia Farmaceutici SpA
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Filing: 1991-11-20
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Granted: 1993-04-13
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Expires: 2011-11-20
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Abstract

Abstract The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds possess interesting and precious bioplastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing: 1) a pharmacologically active substance or an association of pharmacologically active substances and 2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics. The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hyaluronic acid esters.

Inventors

  • 👤 Francesco Della Valle
  • 👤 Aurelio Romeo

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 10:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/30; A61K47/36; A61K8/00; A61K8/18; A61K8/72; A61K8/73; A61K8/735; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L17/00; A61L17/06; A61Q; A61Q19/00; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072; C08L; C08L5/00; C08L5/08; A61Q19/08

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 39 words
A partial ester of hyaluronic acid with an alcohol of the aliphatic, araliphatic, cycloaliphatic or heterocyclic series wherein at least a first portion of the carboxylic acid groups of said hyaluronic acid are salified with a therapeutically active amine.
Claim 2
Dependent Claim 39 words
A partial ester of hyaluronic acid with an alcohol of the aliphatic, araliphatic, cycloaliphatic or heterocyclic series wherein at least a first portion of the carboxylic acid groups of said hyaluronic acid are salified with a therapeutically active amine.
Claim 3
Dependent Claim 35 words
A partial ester of hyaluronic acid according to claim 1, wherein a second portion of the carboxylic acid groups of said hyaluronic acid is salified with an alkaline or alkaline earth metal, magnesium or aluminum.
Claim 4
Dependent Claim 65 words
A partial ester of hyaluronic acid according to claim 1, wherein said therapeutically active amine is a member selected from the group consisting of alkaloids, peptides, phenothiazines, benzodiazepines, thioxanthenes, hormones, vitamins, anticonvulsants, antipsychotics, antiemetics, anesthetics, hypnotics, anorexics, tranquilizers, muscle relaxants, coronary vasodilators, antineoplastics, antibiotics, antibacterials, antivirals, antimaralarials, carbonci anhydrase inhibitors, nonsteroid antiinflammatory agents, vasoconstrictors, cholinergic agonists, cholinergic antagonists, adrenergic agonists, adrenergic antagonists, and narcotic antagonists.
Claim 5
Dependent Claim 15 words
A partial ester according to claim 1, which is in the form of a microcapsule.
Claim 6
Dependent Claim 15 words
A partial ester according to claim 3, which is in the form of a microcapsule.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1996-04-12 1996-10-12 1997-04-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2000-04-12 2000-10-12 2001-04-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2004-04-12 2004-10-12 2005-04-13 $7700.00 Window Closed / Lapsed

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