US4716224A
Expired / Lapsed
US
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Crosslinked hyaluronic acid and its use
Assignee: Seikagaku Corp
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Filing: 1985-05-02
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Granted: 1987-12-29
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Expires: 2005-05-02
Abstract
Abstract Crosslinked hyaluronic acid or salts thereof prepared by crosslinking hyaluronic acid or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index or number is 5 or more per 1000 repeating disaccharides composed of glucronic acid in hyaluronic acid and N-acetylglucosamine, and having various medical and cosmetic uses.
Inventors
- 👤 Katukiyo Sakurai
- 👤 Yoshio Ueno
- 👤 Takashi Okuyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:41
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; A; A61; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/73; A61K8/735; A61K9/00; A61K9/70; A61L; A61L31/00; A61L31/04; A61L31/042; A61L31/043; A61L31/044; A61Q; A61Q19/00; C08B37/0072; C08L; C08L5/00; C08L5/08; A61Q5/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
97 words
A crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof produced by crosslinking hyaluronic acid or a pharmaceutically acceptable salt thereof with a polyfunctional epoxy compound selected from the group consisting of halomethyloxirane compounds and a bisepoxy compound selected from the group consisting of 1,2-bis(2,3-epoxypropoxy) ethane, 1,4-bis(2,3-epoxypropoxy) butane, 1,6-bis(2,3-epoxypropoxy) hexane and a diglycidyl ether of biophenol A or bisphenol F, which has a crosslinking index of 5 to 20 per 1000 repeating disaccharide units composed of glucoronic acid and N-acetylglucosamine in hyaluronic acid, said crosslinked hyaluronic acid or pharmaceutically acceptable salt thereof being water soluble and stringy.
Claim 2
Dependent Claim
97 words
A crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof produced by crosslinking hyaluronic acid or a pharmaceutically acceptable salt thereof with a polyfunctional epoxy compound selected from the group consisting of halomethyloxirane compounds and a bisepoxy compound selected from the group consisting of 1,2-bis(2,3-epoxypropoxy) ethane, 1,4-bis(2,3-epoxypropoxy) butane, 1,6-bis(2,3-epoxypropoxy) hexane and a diglycidyl ether of biophenol A or bisphenol F, which has a crosslinking index of 5 to 20 per 1000 repeating disaccharide units composed of glucoronic acid and N-acetylglucosamine in hyaluronic acid, said crosslinked hyaluronic acid or pharmaceutically acceptable salt thereof being water soluble and stringy.
Claim 3
Dependent Claim
21 words
The crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof of claim 1, having a non-Newtonian index of 0.5 to 0.8.
Claim 4
Dependent Claim
22 words
The crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof of claim 2, wherein said polyfunctional epoxy compound is a halomethyloxirane compound.
Claim 5
Dependent Claim
29 words
The crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof of claim 3, wherein said halomethyloxirane compound is selected from the group consisting of epichlorohydrin, epibromohydrin, β-methylepichlorohydrin and β-methylepibromohydrin.
Claim 6
Dependent Claim
21 words
The pharmaceutically acceptable salts of claim 2, which is selected from the alkaline metal salts and the alkaline earth metal salts.
Claim 7
Dependent Claim
23 words
The crosslinked hyaluronic acid or pharmaceutically acceptable salt thereof of claim 1, which has a crosslinking index of 5 to less than 10.
Claim 8
Dependent Claim
37 words
A pharmaceutical composition for treating arthritides comprising as the active component, an effective amount of the crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof of claim 1, in combination with a pharmaceutically acceptable carrier or diluent.
Claim 9
Dependent Claim
39 words
An ophthanological composition for application to the eye comprising as the active component, an effective amount of the crosslinked hyaluronic acid or an opthanologically acceptable salt thereof of claim 1, in combination with an ophthanologically acceptable carrier or diluent.
Claim 10
Dependent Claim
29 words
A method of substituting vitreous humor into the eye of an animal comprising administering into the eye of said animal an effective amount of the composition of claim 8.
Claim 11
Dependent Claim
39 words
A cosmetic composition for applying to the skin comprising as the active component, an effective amount of the crosslinked hyaluronic acid or a cosmetically acceptable salt thereof of claim 1, in combination with a cosmetically acceptable carrier or diluent.
Claim 12
Dependent Claim
24 words
A molded medical film comprising a crosslinked hyaluronic acid or a pharmaceutically acceptable salt thereof of claim 1, in the form of a film.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-28 | 1991-06-29 | 1991-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-28 | 1995-06-29 | 1995-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-28 | 1999-06-29 | 1999-12-29 | $7700.00 | Window Closed / Lapsed |