US5128326A
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US
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Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
Assignee: Sanofi Biosurgery Inc
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Filing: 1990-07-23
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Granted: 1992-07-07
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Expires: 2010-07-23
Abstract
Abstract Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.
Inventors
- 👤 Endre A. Balazs
- 👤 Adolf Leshchiner
- 👤 Nancy E. Larsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/30; A61K47/36; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K9/0019; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072; C08L; C08L5/00; C08L5/08; A61K9/0048; A61K9/70; A61K9/7007
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
56 words
A drug delivery system comprising a polymeric component which is an insoluble hyaluronan or a soluble hylan and a selected amount of at least one substance having biological or pharmacological activity and which is controllably releasable from said system so as to effect delivery of a therapeutically effective amount of said substance to a desired site.
Claim 2
Dependent Claim
56 words
A drug delivery system comprising a polymeric component which is an insoluble hyaluronan or a soluble hylan and a selected amount of at least one substance having biological or pharmacological activity and which is controllably releasable from said system so as to effect delivery of a therapeutically effective amount of said substance to a desired site.
Claim 3
Dependent Claim
23 words
A drug delivery system in accordance with claim 1 wherein the polymeric component is a soluble hylan and comprises an aqueous hylan solution.
Claim 4
Dependent Claim
20 words
A drug delivery system in accordance with claim 2 wherein the substance is dissolved or dispersed in the aqueous solution.
Claim 5
Dependent Claim
16 words
A drug delivery system in accordance with claim 2 wherein the solution is a viscoelastic putty.
Claim 6
Dependent Claim
20 words
A drug delivery system in accordance with claim 2 wherein the hylan concentration is about 0.05 to 4% by weight.
Claim 7
Dependent Claim
16 words
A drug delivery system in accordance with claim 2 in the form of an injectable product.
Claim 8
Dependent Claim
16 words
A drug delivery system in accordance with claim 2 in the form of a topical product.
Claim 9
Dependent Claim
13 words
A drug delivery system in accordance with claim 7 and comprising eye drops.
Claim 10
Dependent Claim
35 words
A drug delivery system in accordance with claim 7 wherein the hylan has a molecular weight of at least about 1×10 6 and the concentration of hylan is from about 0.05 to 2% by weight.
Claim 11
Dependent Claim
14 words
A drug delivery system in accordance with claim 2 wherein the substance is serotonin.
Claim 12
Dependent Claim
15 words
A drug delivery system in accordance with claim 4 wherein the substance is salicylic acid.
Claim 13
Dependent Claim
25 words
A method of obtaining a product in accordance with claim 2 comprising dissolving or dispersing the substance in a water or saline solution of hylan.
Claim 14
Dependent Claim
24 words
A method of obtaining a product in accordance with claim 2 comprising mixing a solution or dispersion of the substance with a hylan solution.
Claim 15
Dependent Claim
31 words
A method of obtaining a product in accordance with claim 4 comprising adding the substance to a solution of hylan and adjusting the pH of the resulting mixture to about 2.5.
Claim 16
Dependent Claim
17 words
A drug delivery system in accordance with claim 1 wherein the polymeric component is an insoluble hyaluronan.
Claim 17
Dependent Claim
32 words
A drug delivery system in accordance with claim 15 wherein the insoluble hyaluronan is a cross-linked gel of hyaluronan or a cross-linked gel of hyaluronan and at least one other hydrophilic polymer.
Claim 18
Dependent Claim
28 words
A drug delivery system in accordance with claim 16 wherein the other hydrophilic polymer is any such polymer having a functional group capable of reacting with divinyl sulfone.
Claim 19
Dependent Claim
74 words
A drug delivery system in accordance with claim 17 wherein the other hydrophilic polymer is a natural or synthetic polysaccharide selected from the group consisting of hydroxyethyl cellulose, carboxymethyl cellulose, xanthan gum, glycosaminoglycans, a protein or glycoprotein selected from the group consisting of collagen, elastin, albumin, a globulin, keratin sulfate, a sulfated aminoglycosaminoglycan and a synthetic water soluble polymer, selected from the group consisting of polyvinyl alcohol and its co-polymers and co-polymers of poly-(hydroxyethyl)methacrylate.
Claim 20
Dependent Claim
30 words
A drug delivery system in accordance with claim 16 wherein the insoluble hyaluronan is in the form of a molecular cage and the substance is dispersed within said molecular cage.
Claim 21
Dependent Claim
28 words
A drug delivery system in accordance with claim 16 wherein the substance is covalently bonded to the macromolecules of hyaluronan or said at least one other hydrophilic polymer.
Claim 22
Dependent Claim
17 words
A drug delivery system in accordance with claim 19 in combination with a support or substrate therefor.
Claim 23
Dependent Claim
23 words
The combination in accordance with claim 21 wherein the support or substrate is a polymeric porous sponge, a gauze or a polymeric film.
Claim 24
Dependent Claim
41 words
A method of obtaining a product in accordance with claim 16 comprising placing the gel into a solution of the substance and allowing the substance to diffuse into the gel whereby a product having the substance uniformly dispersed therethrough is obtained.
Claim 25
Dependent Claim
44 words
A method of obtaining a product in accordance with claim 16 comprising dehydrating the gel and placing the dehydrated gel into a solution of the substance to cause reswelling of the dehydrated gel, said substance being diffused into the gel while the reswelling occurs.
Claim 26
Dependent Claim
23 words
A method in accordance with claim 24 wherein dehydrating is effected by treating the gel with a water miscible solvent or by drying.
Claim 27
Dependent Claim
14 words
A method in accordance with claim 25 wherein a water miscible solvent is used.
Claim 28
Dependent Claim
17 words
A method in accordance with claim 26 wherein the water miscible solvent is ethanol, isopropanol or acetone.
Claim 29
Dependent Claim
43 words
A method of obtaining a product in accordance with claim 16 comprising placing a concentrated gel in a solution of said substance and allowing the gel to swell in said solution whereby the substance is diffused into the gel while it is swelling.
Claim 30
Dependent Claim
39 words
A drug delivery ststem in accordance with claim 16 wherein when the insoluble hyaluronan is a cross-linked hyaluronan gel and at least one other hydrophilic polymer, the hyaluronan comprises from 5 to 95% by weight of said insoluble hyaluronan.
Claim 31
Dependent Claim
68 words
A method of obtaining a product in accordance with claim 20 which comprises subjecting hyaluronan or a mixture of hyaluronan and the other hydrophilic polymer to a cross-linking reaction in the presence of said substance provided that said substance has a chemical group reactive toward the cross-linking agent to thereby cause the formation of covalent bonds between said chemical group and the hyaluronan or the other hydrophilic polymer.
Claim 32
Dependent Claim
16 words
A method in accordance with claim 30 wherein the chemical group is hydroxyl, amino or sulfhydryl.
Claim 33
Dependent Claim
12 words
A method in accordance with claim 30 wherein said substance is gentamicin.
Claim 34
Dependent Claim
21 words
A drug delivery system in accordance with claim 21 and comprising a membrane formed of a gel of hyaluronan containing gentamicin.
Claim 35
Dependent Claim
24 words
A drug delivery system in accordance with claim 21 and comprising a membrane formed of a gel of hyaluronan and chondroitin sulfate containing gentamicin.
Claim 36
Dependent Claim
21 words
A drug delivery system in accordance with claim 20 and comprising a gel of cross-linked hyaluronan and gentamicin covalently attached thereto.
Claim 37
Dependent Claim
17 words
A drug delivery system in accordance with claim 21 and comprising a gel of hyaluronan containing mydriacyl.
Claim 38
Dependent Claim
27 words
A drug delivery system in accordance with claim 21 and comprising a porous polymeric sponge, said sponge having a hyaluronan gel immobilized therein together with said substance.
Claim 39
Dependent Claim
14 words
A drug delivery system in accordance with claim 37 wherein said substance is serotonin.
Claim 40
Dependent Claim
17 words
A drug delivery system in accordance with claim 37 wherein said sponge is formed of a polyurethane.
Claim 41
Dependent Claim
26 words
A drug delivery system in accordance with claim 21 and comprising a cotton gauze, said gauze having a hyaluronan gel immobilized therein together with said substance.
Claim 42
Dependent Claim
14 words
A drug delivery system in accordance with claim 40 wherein said substance is gentamicin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-07 | 1996-01-06 | 1996-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-07 | 2000-01-06 | 2000-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-07 | 2004-01-06 | 2004-07-07 | $7700.00 | Window Closed / Lapsed |