Patent US6334872B1 successfully refreshed from Google Patents.
US6334872B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for treating diseased or damaged organs
Assignee: Organogenesis Inc
•
Filing: 1997-07-07
•
Granted: 2002-01-01
•
Expires: 2017-07-07
Abstract
Abstract This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
Inventors
- 👤 Paul L. Termin
- 👤 Robert M. Carr, Jr.
- 👤 Kimberlie D. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:55
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/22; A61L27/24; A61L27/28; A61L27/34; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2/3094; A61F2002/30971; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2240/00; A61F2240/001; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
89 words
A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
Claim 2
Independent Claim
89 words
A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
Claim 3
Dependent Claim
14 words
The method of claim 1 , wherein said prosthesis further comprises a third layer.
Claim 4
Dependent Claim
14 words
The method of claim 1 , wherein said first layer provides a flow surface.
Claim 5
Dependent Claim
12 words
The method of claim 3 , wherein said flow surface is smooth.
Claim 6
Dependent Claim
12 words
The method of claim 3 , wherein said flow surface is thrombosis-resistant.
Claim 7
Independent Claim
110 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in the patient with a tubular prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises (a) a first layer that provides a smooth flow surface, wherein said first layer is derived from acid-extracted fibrillar or non-fibrillar collagen; and (b) a second layer that provides structural stability, wherein said second layer is derived from the tunica submucosa of the small intestine of a mammal.
Claim 8
Independent Claim
110 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in the patient with a tubular prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises (a) a first layer that provides a smooth flow surface, wherein said first layer is derived from acid-extracted fibrillar or non-fibrillar collagen; and (b) a second layer that provides structural stability, wherein said second layer is derived from the tunica submucosa of the small intestine of a mammal.
Claim 9
Dependent Claim
16 words
The method of claim 6 , wherein the second layer is crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride.
Claim 10
Independent Claim
121 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, has a thickness of between about 50 microns to about 150 microns, and is pliable, semi-permeable, and suturable.
Claim 11
Independent Claim
121 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, has a thickness of between about 50 microns to about 150 microns, and is pliable, semi-permeable, and suturable.
Claim 12
Independent Claim
136 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular, collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, and is pliable, semi-permeable, and suturable, and wherein said prosthesis has a diameter selected from the group consisting of less than 6 mm, between 6 to 12 mm, and greater than 12 mm.
Claim 13
Independent Claim
136 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular, collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, and is pliable, semi-permeable, and suturable, and wherein said prosthesis has a diameter selected from the group consisting of less than 6 mm, between 6 to 12 mm, and greater than 12 mm.
Claim 14
Dependent Claim
17 words
The method of claim 9 , wherein said prosthesis has a diameter of less than 6 mm.
Claim 15
Dependent Claim
18 words
The method of claim 9 , wherein said prosthesis has a diameter of between 6 to 12 mm.
Claim 16
Dependent Claim
17 words
The method of claim 9 , wherein said prosthesis has a diameter of greater than 12 mm.
References Cited (Backward Citations)
US3272204A
Cited
US3562820A
Cited
US4082507A
Cited
US4319363A
Cited
US4252759A
Cited
US4539716A
Cited
US4420339A
Cited
US4902289A
Cited
US4787900A
Cited
US4502159A
Cited
US4801299A
Cited
US5108424A
Cited
GB2153235A
Cited
US5197977A
Cited
US4842575A
Cited
US4814120A
Cited
US4923380A
Cited
US5037377A
Cited
US4629458A
Cited
US5002583A
Cited
US4822361A
Cited
US4902290A
Cited
US5061276A
Cited
US5263983A
Cited
WO1989010100A1
Cited
US4956178A
Cited
US4902508A
Cited
US5024671A
Cited
US5026381A
Cited
EP0397500A2
Cited
US5084065A
Cited
US5106949A
Cited
US5256418A
Cited
US5378469A
Cited
EP0493788A1
Cited
US5376110A
Cited
US5968092A
Cited
US5376376A
Cited
US5374515A
Cited
US5460962A
Cited
US5879383A
Cited
US5776182A
Cited
US5851230A
Cited
US5733337A
Cited
US5948654A
Cited
US5993844A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-12-31 | 2005-07-02 | 2006-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-12-31 | 2009-07-02 | 2010-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-12-31 | 2013-07-02 | 2014-01-01 | $7700.00 | Window Closed / Lapsed |