US5197977A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery collagen-impregnated synthetic vascular graft
Assignee: Boston Scientific Scimed Inc
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Filing: 1992-04-30
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Granted: 1993-03-30
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Expires: 2012-04-30
Abstract
Abstract A collagen impregnated vascular graft including drug materials complexed with the collagen to be released slowly from the graft following implant. The graft is a porous synthetic vascular graft substrate having collagen fixed to the graft substrate and cross-linking the collagen in situ to render the porous substrate blood-tight. The drug materials complexed with the collagen fibrils may include antithrombic agents, antibacterial, antimicrobial agents, antifungal agents and the like.
Inventors
- 👤 Harmon Hoffman, Jr.
- 👤 Kemal Schankereli
- 👤 Milos Chvapil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:30
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/28; A61L27/34; A61L27/507; A61F2002/065; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
114 words
A synthetic vascular graft comprising: a tubular flexible porous graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min cm 2 (purified water at 120 mm Hg); the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water insoluble collagen fibrils complexed with an effective amount of a drug and admixed with a plasticizer for rendering the graft blood-tight and flexible and providing for substained release of the drug portion of the complex after immplantation, the collagen fibrils applied by application of an aqueous slurry of water-insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked.
Claim 2
Dependent Claim
114 words
A synthetic vascular graft comprising: a tubular flexible porous graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min cm 2 (purified water at 120 mm Hg); the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water insoluble collagen fibrils complexed with an effective amount of a drug and admixed with a plasticizer for rendering the graft blood-tight and flexible and providing for substained release of the drug portion of the complex after immplantation, the collagen fibrils applied by application of an aqueous slurry of water-insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked.
Claim 3
Dependent Claim
37 words
The vascular graft of claim 1, wherein the drug portion of the complex is a pharmaceutical agent selected from the group consisting of antimicrobial agents, antibacterial agents, antifungal agents, antithrombogenic agents, cell-proliferation promoting agents and mixtures thereof.
Claim 4
Dependent Claim
36 words
The vascular graft of claim 1, wherein the collagen fibril-drug complex is applied in at least three applications formed by applying aqueous slurries of collagen fibrils which have been dried between applications and cross-linked after application.
Claim 5
Dependent Claim
13 words
The vascular graft of claim 1, wherein the porous substrate is polyethylene terephthalate.
Claim 6
Dependent Claim
12 words
The vascular graft of claim 4, wherein the porous substrate is knitted.
Claim 7
Dependent Claim
12 words
The vascular graft of claim 4, wherein the porous substrate is woven.
Claim 8
Dependent Claim
19 words
The vascular graft of claim 4, wherein the inner and outer surface of the substrate have a velour surface.
Claim 9
Dependent Claim
18 words
The vascular graft of claim 1, wherein the collagen fibrils-drug complex is cross-linked by exposure to formaldehyde vapor.
Claim 10
Dependent Claim
15 words
The vascular graft of claim 1, wherein the plasticizer is a biologically compatible polyhydric material.
Claim 11
Dependent Claim
11 words
The vascular graft of claim 9, wherein the plasticizer is sorbitol.
Claim 12
Dependent Claim
11 words
The vascular graft of claim 9, wherein the plasticizer is glycerine.
Claim 13
Dependent Claim
104 words
A synthetic vascular graft comprising: a tubular flexible porous polyethylene terephthalate graft substrate having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the inner surface having been treated with collagen fibrils complexed with a drug and admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface; the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water-insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the substrate and massaged through the substrate and dried and cross-linked.
Claim 14
Dependent Claim
104 words
A synthetic vascular graft comprising: a tubular flexible porous polyethylene terephthalate graft substrate having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the inner surface having been treated with collagen fibrils complexed with a drug and admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface; the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water-insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the substrate and massaged through the substrate and dried and cross-linked.
Claim 15
Dependent Claim
17 words
The synthetic vascular graft of claim 12, wherein the collagen is applied in at least three applications.
Claim 16
Dependent Claim
22 words
The synthetic vascular graft of claim 13, wherein the aqueous slurry contains between about 1.5 to 4.0 total weight percent collagen fibrils.
Claim 17
Dependent Claim
19 words
The synthetic vascular graft of claim 14, wherein the slurry contains between about 6 to 10 weight percent plasticizer.
Claim 18
Dependent Claim
15 words
The synthetic vascular graft of claim 15, wherein the collagen has been cross-linked with formaldehyde.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-29 | 1996-09-28 | 1997-03-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-29 | 2000-09-28 | 2001-03-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-29 | 2004-09-28 | 2005-03-30 | $7700.00 | Window Closed / Lapsed |