EP0493788A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Three-layer vascular prosthesis
Assignee: Individual
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Filing: 1991-12-23
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Granted: —
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Expires: 2011-12-23
Abstract
Abstract The invention relates to three-layer vascular prostheses comprising an internal layer 1 , a middle layer 2 and an external layer 3 which is characterized in that the middle layer 2 is made from a physiologically non-resorbable, porous material, and the internal layer 1 and the external layer 3 are self-supporting and are made from a physiologically resorbable, fibrillar material, and are tanned. The internal layer 1 and the external layer 3 preferably consist of collagen, but have different resorbability. The middle layer 2 is preferably made from inert fibres, preferably synthetic fibres, by means of textile technology. The biologically resorbable layers preferably comprise chemically or physically bonded or incorporated pharmacologically active substances.
Inventors
- 👤 Milan Krajicek Csc. Mudr.
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-22 22:32
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/28; A61L27/34; A61L27/50; A61L27/507; B; B29; B29C; B29C48/00; B29C48/25; B29C48/30; B29C48/32; B29C48/33; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30032; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/30205; A61F2002/30217; A61F2002/30224; A61F2002/30235; A61F2002/30667; A61F2002/30677; A61F2/3094; A61F2002/30971; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0067; A61F2230/0069; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0014; A61F2250/003; A61F2250/0058; A61F2250/0067; A61F2310/00; A61F2310/00005; A61F2310/00365; B29C48/03; B29C48/09; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
56 words
Three-layer vascular prostheses, comprising an internal layer (1), a middle layer (2) and an external layer (3), characterized in that the middle layer (2) is made from a physiologically non-resorbable porous material, and the internal layer (1) and the external layer (3) are self-supporting and are made from a physiologically resorbable fibrillar material, and are tanned.
Claim 2
Dependent Claim
16 words
The prostheses according to claim 1, characterized in that they are in the form of tubes.
Claim 3
Dependent Claim
38 words
The prostheses according to claim 1 or 2, characterized in that the non-resorbable porous material of the middle layer (2) consists of synthetic fibres, preferably physiologically inert polyester fibres, and preferably being made by means of textile technology.
Claim 4
Dependent Claim
28 words
The prostheses according to one of claims 1 to 3, characterized in that the internal layer (1) and/or the external layer (3) consist of collagen, preferably bovine collagen.
Claim 5
Dependent Claim
56 words
The prostheses according to one of claims 1 to 4, characterized in that the internal layer (1) is tanned to such an extent that its resorption is completed 2 to 3 months after implantation, and/or the external layer (3) is tanned to such an extent that its resorption is completed 3 to 6 weeks after implantation.
Claim 6
Dependent Claim
64 words
The prostheses according to one of claims 1 to 5, characterized in that a pharmacologically active agent, preferably heparin, acetylsalicylic acid and/or prostaglandin, is chemically or physically bonded to or incorporated into the material of the internal layer (1), and/or a pharmacologically active agent, preferably fibronectin and/or antibiotics, is chemically or physically bonded to or incorporated into the material of the external layer (3).
Claim 7
Dependent Claim
44 words
The prostheses according to one of claims 1 to 6, characterized in that the material of the internal layer (1) and/or the material of the external layer (3) comprises an aqueous solution of glycerol in a concentration of 5 to 30 % by mass.
Claim 8
Dependent Claim
85 words
The prostheses according to one of claims 1 to 7, characterized in that they comprise a reinforcing spiral made of a solid, biologically inert liner, preferably made of polytetrafluoroethylene or a polyester, provided between the middle layer (2) and the external layer (3), the diameter of the liner preferably corresponding to the total diameter of the prosthesis, and/or a reinforcing spiral made of a solid, biological inert liner, preferably made of polytetrafluoroethylene or a polyester, provided on the outer surface of the external layer (3).
Claim 9
Dependent Claim
49 words
The prosthesis according to one of claims 1 to 8, characterized in that the internal layer (1), the middle layer (2) and the external layer (3) have the form of a truncated cone tube, the end diameters of each of the tubes preferably differing by at least 20 %.
Claim 10
Dependent Claim
25 words
The prostheses according to one of claims 1 to 9, characterized in that the middle layer (2) comprises a visible mark of the longitudinal axis.
Claim 11
Independent Claim
172 words
A method for manufacturing the prostheses according to claims 1 to 10, comprising the following steps: (A) Preparing a self-supporting internal layer (1) from a physiologically resorbable fibrillar material, preferably made from collagen, and more preferably made from bovine collagen, (B) tanning the internal layer (1) by means of a biologically acceptable tanning agent, preferably glutaraldehyde, trimethylaminotriazin or triethylaminotriazin, to reduce the swelling capacity, preferably at a temperature of 50 to 70 °C, (C) providing a middle layer (2) by applying a layer of a physiologically non-resorbable, porous material, preferably of physiologically inert fibres and more preferably of synthetic fibres, onto the internal layer (1), (D) providing an external layer (3) by applying a self-supporting layer of a physiologically resorbable fibrillar material, preferably made from collagen, and more preferably made from bovine collagen, onto the middle layer (2), and (E) tanning the external layer (3) by means of a biologically acceptable tanning agent, preferably glutaraldehyde, trimethylaminotriazin or triethylaminotriazin, to reduce the swelling capacity, preferably at a temperature of 45 to 58 °C.
Claim 12
Dependent Claim
262 words
The method according to claim 11, characterized by one or more or all of the following measures: - Before step A, or after step A and before step B, or after step B and before step C, a pharmacologically active agent, preferably heparin, acetylsalicylic acid and/or prostaglandin, is chemically or physically bonded to or incorporated into the material of the internal layer (1), - before the formation of the external layer (3) in step D, or after step D and before step E, or after step E, a pharmacologically active agent, preferably fibronectin and/or antibiotics, is chemically or physically bonded to or incorporated into the material of the external layer (3); - in step C, fibres, a non-woven fabric or a textile web made of a physiologically inert polyester are used as non-resorbable porous material; - an aqueous solution of glycerol is incorporated into the internal layer (1) and/or the external layer (3) in a concentration of 5 to 30 % by mass; - a reinforcing spiral made of a solid, biologically inert liner, preferably made of polytetrafluoroethylene or a polyester, is provided between the middle layer (2) and the external layer (3) and/or on the outer surface of the external layer (3); - the internal layer (1), the middle layer (2) and the external layer (3) are made such that they have the form of a truncated cone tube, the end diameters of each of the tubes preferably differing by at least 20 %; - a visible mark of the longitudinal axis is provided in or on the middle layer (2).
References Cited (Backward Citations)
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