US5733337A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue repair fabric
Assignee: Organogenesis Inc
•
Filing: 1995-04-07
•
Granted: 1998-03-31
•
Expires: 2015-04-07
Abstract
Abstract This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
Inventors
- 👤 Robert M. Carr, Jr.
- 👤 Paul L. Termin
- 👤 Kimberlie D. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:55
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61L2/00; A61L2/16; A61L2/18; A61L27/14; A61L27/22; A61L27/24; A61L27/3604; A61L27/3687; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/0077
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
115 words
A prosthesis comprising two or more superimposed, bonded layers of collagenous tissue material, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium (b) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (c) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (d) wherein said prosthesis is sterilized with peracetic acid, which, when implanted into a mammalian patient, the prosthesis undergoes controlled biodegradation occurring with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 2
Dependent Claim
115 words
A prosthesis comprising two or more superimposed, bonded layers of collagenous tissue material, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium (b) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (c) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (d) wherein said prosthesis is sterilized with peracetic acid, which, when implanted into a mammalian patient, the prosthesis undergoes controlled biodegradation occurring with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 3
Dependent Claim
16 words
The prosthesis of claim 1 wherein the shape of said prosthesis is flat, tubular, or complex.
Claim 4
Dependent Claim
17 words
The prosthesis of claim 1, wherein said prosthesis is crosslinked with the crosslinking agent 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride.
Claim 5
Dependent Claim
13 words
The prosthesis of claim 1, wherein sulfo-N-hydroxysuccinimide is added to the crosslinking agent.
Claim 6
Dependent Claim
13 words
The prosthesis of claim 1, wherein acetone is added to the crosslinking agent.
Claim 7
Dependent Claim
10 words
The prosthesis of claim 1, wherein said prosthesis is non-immunogenic.
Claim 8
Dependent Claim
28 words
The prosthesis of claim 1 wherein one or more surfaces of said prosthesis is coated with a collagenous dispersion or gel which acts as a smooth flow surface.
Claim 9
Dependent Claim
11 words
The prosthesis of claim 1 wherein said prosthesis further contains pores.
Claim 10
Dependent Claim
15 words
The prosthesis of claim 1 wherein said prosthesis is further composed of chopped collagen fibers.
Claim 11
Dependent Claim
14 words
The prosthesis of claim 1 wherein said prosthesis is further composed of collagen threads.
Claim 12
Dependent Claim
22 words
The prosthesis of claim 10 wherein said collagen threads are arranged to form a felt, a bundle, a weave or a braid.
Claim 13
Dependent Claim
18 words
The prosthesis of any of claims 9-11 wherein said collagen fibers or threads are partially or completely crosslinked.
Claim 14
Dependent Claim
22 words
The prosthesis of claim 1 wherein said prosthesis additionally contains an anticoagulant; one or more antibiotics, or one or more growth factors.
Claim 15
Independent Claim
130 words
A method of repairing or replacing a damaged tissue comprising implanting a prosthesis in a patient comprising two or more superimposed, bonded layers of collagenous tissue material (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b ) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (c) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (d) wherein said prosthesis is sterilized with peracetic acid, which, when implanted into a mammalian patient, the prosthesis undergoes controlled biodegradation occurring with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 16
Independent Claim
130 words
A method of repairing or replacing a damaged tissue comprising implanting a prosthesis in a patient comprising two or more superimposed, bonded layers of collagenous tissue material (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b ) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (c) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (d) wherein said prosthesis is sterilized with peracetic acid, which, when implanted into a mammalian patient, the prosthesis undergoes controlled biodegradation occurring with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 17
Dependent Claim
20 words
The prosthesis of claim 1, wherein heat for said heat welding is applied between from 60° C. to 65° C.
Claim 18
Dependent Claim
16 words
The prosthesis of claim 15, wherein heat for said heat welding is applied at 62° C.
Claim 19
Dependent Claim
22 words
The prosthesis of claim 1 wherein heat for said heat welding is applied between from about 7 minutes to about 24 hours.
Claim 20
Dependent Claim
17 words
The prosthesis of claim 17, wherein heat for said heat welding is applied for about one hour.
Claim 21
Dependent Claim
122 words
A prosthesis comprising two or more layers of collagenous tissue, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b) wherein the layers are formed into a flat prosthesis, (c) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (d) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (e) wherein said prosthesis is sterilized with peracetic acid, which when said prosthesis is implanted into a mammalian patient, undergoes controlled biodegradation with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 22
Dependent Claim
122 words
A prosthesis comprising two or more layers of collagenous tissue, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b) wherein the layers are formed into a flat prosthesis, (c) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (d) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (e) wherein said prosthesis is sterilized with peracetic acid, which when said prosthesis is implanted into a mammalian patient, undergoes controlled biodegradation with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 23
Dependent Claim
122 words
A prosthesis comprising two or more layers of collagenous tissue, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b) wherein the layers are formed into a tubular prosthesis, (c) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (d) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (e) wherein said prosthesis is sterilized with peracetic acid, which when said prosthesis is implanted into a mammalian patient, undergoes controlled biodegradation with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 24
Dependent Claim
122 words
A prosthesis comprising two or more layers of collagenous tissue, (a) wherein the layers of collagenous tissue material are sourced from a mammalian source and is the tunica submucosa of the small intestine, fascia lata, dura mater, or pericardium, (b) wherein the layers are formed into a tubular prosthesis, (c) wherein the layers are bonded together by heat welding from about 50° C. to about 75° C., (d) wherein said prosthesis is crosslinked with a crosslinking agent that permits bioremodeling, and, (e) wherein said prosthesis is sterilized with peracetic acid, which when said prosthesis is implanted into a mammalian patient, undergoes controlled biodegradation with adequate replacement by the patient's living cells such that the implanted prosthesis is remodeled by the living cells.
Claim 25
Dependent Claim
23 words
The prosthesis of claims 18 or 19, wherein said prosthesis contains an anticoagulant, one or more antibiotics, or one or more growth factors.
Claim 26
Dependent Claim
15 words
The prosthesis of claims 18 or 19, wherein said crosslinking agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride.
Claim 27
Dependent Claim
19 words
The prosthesis of claim 18, wherein said layers are bonded at the periphery to form an inner hollow region.
Claim 28
Dependent Claim
19 words
The prosthesis of claim 19, wherein the periphery of said layers are bonded to form an inner hollow region.
References Cited (Backward Citations)
US3562820A
Cited
US4902289A
Cited
US4787900A
Cited
US4801299A
Cited
US4503159A
Cited
US4822361A
Cited
US5061276A
Cited
US5263983A
Cited
US4956178A
Cited
US4902508A
Cited
US5256418A
Cited
US5378469A
Cited
EP0493788A1
Cited
US5281422A
Cited
US5372821A
Cited
US5460962A
Cited
US5571216A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-03-30 | 2001-09-29 | 2002-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-30 | 2005-09-29 | 2006-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-30 | 2009-09-29 | 2010-03-31 | $7700.00 | Window Closed / Lapsed |