US4902290A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of a vessel prosthesis impregnated with crosslinked gelatin
Assignee: B Braun Surgical AG
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Filing: 1988-07-29
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Granted: 1990-02-20
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Expires: 2008-07-29
Abstract
Abstract The invention relates to a process to prepare vessel prostheses formed from a porous basic body and an impregnating coating of crosslinked gelatin for sealing the pores. Crosslinking takes place accompanied by the use of a diisocyanate. The impregnating coating has good mechanical and physiological properties.
Inventors
- 👤 Peter Fleckenstein
- 👤 Heinz-Helmut Werner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:30
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31551; Y10T428/31565
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
45 words
A process for producing impregnated vessel prostheses, wherein a porous vessel prosthesis is impregnated with an aqueous gelatin solution, the gelatin solution is allowed to gel, the gelatin solution is then carefully partially dehydrated and then the impregnating coating obtained is crosslinked with a diisocyanate.
Claim 2
Dependent Claim
45 words
A process for producing impregnated vessel prostheses, wherein a porous vessel prosthesis is impregnated with an aqueous gelatin solution, the gelatin solution is allowed to gel, the gelatin solution is then carefully partially dehydrated and then the impregnating coating obtained is crosslinked with a diisocyanate.
Claim 3
Dependent Claim
21 words
A process according to claim 1, wherein the impregnation of porous vessel prosthesis with the gelatin solution takes place by immersion.
Claim 4
Dependent Claim
18 words
A process according to claim 1, wherein porous vessel prosthesis is only impregnated once with the gelatin solution.
Claim 5
Dependent Claim
25 words
A process according to claim 1, wherein for crosslinking the gelatin impregnating coating use is made of a solution of diisocyanate in an organic solvent.
Claim 6
Dependent Claim
21 words
A process according to claim 1, wherein the gelatin-impregnated vessel prosthesis is immersed in the cross-linking solution and moved relative thereto.
Claim 7
Dependent Claim
50 words
A process according to claim 1, wherein the moisture content and also the plasticizer content of the partly dehydrated, not yet crosslinked gelatin impregnating coating is adjusted in such a way so as to be substantially in equilibrium with the moisture content and the plasticizer content of the crosslinking solution.
Claim 8
Dependent Claim
16 words
A process according to claim 2, wherein the impregnation takes place by immersion under a vacuum.
Claim 9
Dependent Claim
42 words
A process according to claim 1 wherein the moisture content of the partially dehydrated, not yet cross-linked gelatin impregnating coating is adjusted in such a way so as to be substantially in equilibrium with the moisture content of the cross linking solution.
Claim 10
Dependent Claim
101 words
A process for producing an impregnated vessel prosthesis, which comprises the steps of: (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution; (b) allowing the gelatin solution to gel; (c) partially dehydrating the gelatin solution to obtain an impregnating coating; and (d) crosslinking the impregnating coating by applying thereto a solution of 0.03 to 3% by weight of diisocyanate, 0 to 60% by weight of plasticizer, 30 to 95% by weight of solvent, and 5 to 70% by weight of water, the quantity ratios being matched to one another so that the diisocyanate is present in the dissolved state.
Claim 11
Dependent Claim
101 words
A process for producing an impregnated vessel prosthesis, which comprises the steps of: (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution; (b) allowing the gelatin solution to gel; (c) partially dehydrating the gelatin solution to obtain an impregnating coating; and (d) crosslinking the impregnating coating by applying thereto a solution of 0.03 to 3% by weight of diisocyanate, 0 to 60% by weight of plasticizer, 30 to 95% by weight of solvent, and 5 to 70% by weight of water, the quantity ratios being matched to one another so that the diisocyanate is present in the dissolved state.
Claim 12
Dependent Claim
74 words
A process for producing an impregnated vessel prosthesis, which comprises the steps of: (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution; (b) allowing the gelatin solution to gel; (c) partially dehydrating the gelatin solution to obtain an impregnating coating; and (d) crosslinking the impregnating coating by applying thereto a solution containing a diisocyanate wherein the crosslinking solution is constantly circulated during the crosslinking reaction and insoluble by-products are removed by filtration.
Claim 13
Dependent Claim
74 words
A process for producing an impregnated vessel prosthesis, which comprises the steps of: (a) impregnating a porous vessel prosthesis with an aqueous gelatin solution; (b) allowing the gelatin solution to gel; (c) partially dehydrating the gelatin solution to obtain an impregnating coating; and (d) crosslinking the impregnating coating by applying thereto a solution containing a diisocyanate wherein the crosslinking solution is constantly circulated during the crosslinking reaction and insoluble by-products are removed by filtration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-19 | 1993-08-21 | 1994-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-19 | 1997-08-21 | 1998-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-19 | 2001-08-21 | 2002-02-20 | $7700.00 | Window Closed / Lapsed |