US4801299A
Expired / Lapsed
US
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Body implants of extracellular matrix and means and methods of making and using such implants
Assignee: University Patents Inc
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Filing: 1984-02-22
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Granted: 1989-01-31
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Expires: 2004-02-22
Abstract
Abstract A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.
Inventors
- 👤 Klaus Brendel
- 👤 Raymond C. Duhamel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:24
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3633; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/10; A61F2/28; A61L27/3683; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917; Y10S623/919; Y10S623/92; Y10S623/923
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
36 words
A sterile body implant comprising a body derived structure having as its major component collagens and elastin in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
Claim 2
Dependent Claim
36 words
A sterile body implant comprising a body derived structure having as its major component collagens and elastin in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.
Claim 3
Dependent Claim
33 words
A body implant in accordance with claim 1 wherein said implant is sized and dimensioned to be compatible with the histoarchitecture of a body portion to which the implant is to be attached.
Claim 4
Dependent Claim
35 words
A sterile body implant in accordance with claim 1 wherein said implant is treated shortly after said body structure is removed from the body and prior to substantial chemical cross-linking or change thereof with detergents.
Claim 5
Independent Claim
128 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said anionic detergent being selected from the group consisting of a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane and sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
Claim 6
Independent Claim
128 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said anionic detergent being selected from the group consisting of a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane and sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
Claim 7
Dependent Claim
17 words
A method in accordance with the method of claim 9 wherein said anionic detergent is sodium dodecylsulfate.
Claim 8
Independent Claim
99 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first an second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said first detergent being admixed with a protease inhibitor.
Claim 9
Independent Claim
99 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first an second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said first detergent being admixed with a protease inhibitor.
Claim 10
Independent Claim
98 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said first detergent being admixed with a DNase.
Claim 11
Independent Claim
98 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said first detergent being admixed with a DNase.
Claim 12
Independent Claim
96 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as body implant, said body implant being a bone implant.
Claim 13
Independent Claim
96 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as body implant, said body implant being a bone implant.
Claim 14
Independent Claim
97 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a storing anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said body implant being a tooth implant.
Claim 15
Independent Claim
97 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a storing anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said body implant being a tooth implant.
Claim 16
Independent Claim
97 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said body implant being a skin implant.
Claim 17
Independent Claim
97 words
A method of treating body tissue to remove cellular membranes, nucleic acids, lipids and cytoplasmic components and form extracellular matrix having as one major component collagens and making said body tissue suitable for use as a body implant, said method comprising extracting said tissue with a first and second detergent while maintaining said tissue in a suitable size and form for implantation in the body, said second detergent being a strong anionic detergent and removing said detergents while maintaining said tissue in sterile form for use as a body implant, said body implant being a skin implant.
Claim 18
Independent Claim
74 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major component collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body, said whole structure being a tooth.
Claim 19
Independent Claim
74 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major component collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body, said whole structure being a tooth.
Claim 20
Independent Claim
77 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major components collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body, said whole structure being an area of the skin.
Claim 21
Independent Claim
77 words
A method of implanting in a living body a whole structure for repairing the body, said structure being in the form of extracellular matrix high in collagen from which has been removed nucleic acids, lipids and cytoplasmic components leaving as its major components collagens with said removal being carried out by the use of at least one detergent, said method comprising implanting said structure in a living body, said whole structure being an area of the skin.
Claim 22
Dependent Claim
70 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a first non-denaturing detergent and a second denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body, said detergents being used in sequence and a protease inhibitor being used along with said first detergent.
Claim 23
Dependent Claim
70 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a first non-denaturing detergent and a second denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body, said detergents being used in sequence and a protease inhibitor being used along with said first detergent.
Claim 24
Dependent Claim
19 words
A method in accordance with the method of claim 13 wherein a DNase is admixed with said first detergent.
Claim 25
Dependent Claim
97 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a first non-denaturing detergent and a second denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body, said second detergent being a strongly anionic detergent which is selected from the group consisting of a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane and sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
Claim 26
Dependent Claim
97 words
In a method of forming a body implant from a body tissue the improvement comprising treating said body tissue prior to cross-linking or unwanted deterioration of said tissue with a first non-denaturing detergent and a second denaturing detergent and forming said body implant therefrom suitable for use in implanting in a living body, said second detergent being a strongly anionic detergent which is selected from the group consisting of a water soluble salt of a sulfated higher aliphatic alcohol, sulfonated alkane and sulfonated alkylarene containing from 7 to 22 carbon atoms in a branched or unbranched chain.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-31 | 1992-08-01 | 1993-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-31 | 1996-08-01 | 1997-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-31 | 2000-08-01 | 2001-01-31 | $7700.00 | Window Closed / Lapsed |