US5108424A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen-impregnated dacron graft
Assignee: Maquet Cardiovascular LLC
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Filing: 1991-01-28
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Granted: 1992-04-28
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Expires: 2011-01-28
Abstract
Abstract A collagen-impregnated vascular graft includes a porous synthetic vascular graft substrate formed by knitting or weaving with at least three applications of dispersed collagen fibrils. Plasticizers are incorporated into the collagen slurry before application and the slurry is applied in separate treatments by massage and flow through techniques, cross-linked by exposure to formaldhyde vapor and dried.
Inventors
- 👤 Harmon Hoffman, Jr.
- 👤 Kemal Schankereli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:04
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/28; A61L27/34; A61L27/502; A61F2002/065
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
93 words
A synthetic vascular graft comprising: a tubular flexible porous fabric graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water-insoluble collagen fibrils admixed with a plasticizer for rendering the graft blood-tight and flexible, the collagen fibrils applied by application of an aqueous slurry of water insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked after application.
Claim 2
Dependent Claim
93 words
A synthetic vascular graft comprising: a tubular flexible porous fabric graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water-insoluble collagen fibrils admixed with a plasticizer for rendering the graft blood-tight and flexible, the collagen fibrils applied by application of an aqueous slurry of water insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked after application.
Claim 3
Dependent Claim
13 words
The vascular graft of claim 1, wherein the porous substrate is polyethylene terephthalate.
Claim 4
Dependent Claim
12 words
The vascular graft of claim 2, wherein the porous substrate is knitted.
Claim 5
Dependent Claim
12 words
The vascular graft of claim 2, wherein the porous substrate is woven.
Claim 6
Dependent Claim
19 words
The vascular graft of claim 2, wherein the inner and outer surface of the substrate have a velour surface.
Claim 7
Dependent Claim
17 words
The vascular graft of claim 1, wherein the collagen fibrils are cross-linked by exposure to formaldehyde vapor.
Claim 8
Dependent Claim
15 words
The vascular graft of claim 1 wherein the plasticizer is a biologically compatible polyhydric material.
Claim 9
Dependent Claim
11 words
The vascular graft of claim 7, wherein the plasticizer is sorbitol.
Claim 10
Dependent Claim
11 words
The vascular graft of claim 7, wherein the plasticizer is glycerine.
Claim 11
Dependent Claim
44 words
The vascular graft of claim 1, wherein the cross-linked collagen fibrils are formed from a deposited aqueous slurry of between about 0.5 and 5.0 percent collagen fibrils and about 4 and 12 percent plasticizer by weight, based on the total weight of the slurry.
Claim 12
Dependent Claim
15 words
The vascular graft of claim 1, wherein the collagen fibrils are derived from bovine skin.
Claim 13
Dependent Claim
101 words
A synthetic vascular graft comprising: a tubular flexible porous polyethylene terephthalate fabric graft substrate having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the inner surface having been treated with collagen fibrils admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface; the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the graft and massaged through the substrate and dried and cross-linked.
Claim 14
Dependent Claim
101 words
A synthetic vascular graft comprising: a tubular flexible porous polyethylene terephthalate fabric graft substrate having a porosity of less than about 3,000 ml/min-cm 2 (purified water at 120 mm Hg); the inner surface having been treated with collagen fibrils admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface; the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the graft and massaged through the substrate and dried and cross-linked.
Claim 15
Dependent Claim
19 words
The vascular graft of claim 12, wherein the plasticizer is selected from the group consisting of sorbitol and glycerine.
Claim 16
Dependent Claim
17 words
The synthetic vascular graft of claim 12, wherein the collagen is applied in at least three applications.
Claim 17
Dependent Claim
22 words
The synthetic vascular graft of claim 14, wherein the aqueous slurry contains between about 1.5 to 4.0 total weight percent collagen fibrils.
Claim 18
Dependent Claim
19 words
The synthetic vascular graft of claim 15, wherein the slurry contains between about 6 to 10 weight percent plasticizer.
Claim 19
Dependent Claim
15 words
The synthetic vascular graft of claim 16, wherein the collagen has been cross-linked with formaldehyde.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-28 | 1995-10-28 | 1996-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-28 | 1999-10-28 | 2000-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-28 | 2003-10-28 | 2004-04-28 | $7700.00 | Window Closed / Lapsed |