Patent FR2749558A1 successfully refreshed from Google Patents.
US6334872B1
Expired / Lapsed
US
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Method for treating diseased or damaged organs
Assignee: Organogenesis Inc
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Filing: 1997-07-07
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Granted: 2002-01-01
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Expires: 2017-07-07
Abstract
Abstract This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
Inventors
- 👤 Paul L. Termin
- 👤 Robert M. Carr, Jr.
- 👤 Kimberlie D. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:51
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/22; A61L27/24; A61L27/28; A61L27/34; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30235; A61F2/3094; A61F2002/30971; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2240/00; A61F2240/001; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
89 words
A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
Claim 2
Independent Claim
89 words
A method of treating a patient with a diseased or damaged organ comprising repairing or replacing the diseased or damaged organ said patient with a bioedgradable collagen-containing prosthesis which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from mammalian intestine, fascia lata, or dura mater that provides structural stability, and is pliable, semi-permeable, and suturable.
Claim 3
Dependent Claim
14 words
The method of claim 1 , wherein said prosthesis further comprises a third layer.
Claim 4
Dependent Claim
14 words
The method of claim 1 , wherein said first layer provides a flow surface.
Claim 5
Dependent Claim
12 words
The method of claim 3 , wherein said flow surface is smooth.
Claim 6
Dependent Claim
12 words
The method of claim 3 , wherein said flow surface is thrombosis-resistant.
Claim 7
Independent Claim
110 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in the patient with a tubular prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises (a) a first layer that provides a smooth flow surface, wherein said first layer is derived from acid-extracted fibrillar or non-fibrillar collagen; and (b) a second layer that provides structural stability, wherein said second layer is derived from the tunica submucosa of the small intestine of a mammal.
Claim 8
Independent Claim
110 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in the patient with a tubular prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises (a) a first layer that provides a smooth flow surface, wherein said first layer is derived from acid-extracted fibrillar or non-fibrillar collagen; and (b) a second layer that provides structural stability, wherein said second layer is derived from the tunica submucosa of the small intestine of a mammal.
Claim 9
Dependent Claim
16 words
The method of claim 6 , wherein the second layer is crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride.
Claim 10
Independent Claim
121 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, has a thickness of between about 50 microns to about 150 microns, and is pliable, semi-permeable, and suturable.
Claim 11
Independent Claim
121 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, has a thickness of between about 50 microns to about 150 microns, and is pliable, semi-permeable, and suturable.
Claim 12
Independent Claim
136 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular, collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, and is pliable, semi-permeable, and suturable, and wherein said prosthesis has a diameter selected from the group consisting of less than 6 mm, between 6 to 12 mm, and greater than 12 mm.
Claim 13
Independent Claim
136 words
A method of treating a patient with a diseased or damaged artery or vein comprising repairing or replacing the diseased or damaged artery or vein in said patient with a tubular, collagen-containing prosthesis which all undergoes controlled biodegradation occurring concomitantly with bioremodeling by the host's cells and which functions as a remodeling template for the ingrowth of patient cells, wherein said prosthesis comprises a first layer made from acid-extracted fibrillar or non-fibrillar collagen and has a smooth, uniform diameter geometry, and a second layer made from a collagen material derived from the tunica submucosa of a mammalian small intestine that provides structural stability, and is pliable, semi-permeable, and suturable, and wherein said prosthesis has a diameter selected from the group consisting of less than 6 mm, between 6 to 12 mm, and greater than 12 mm.
Claim 14
Dependent Claim
17 words
The method of claim 9 , wherein said prosthesis has a diameter of less than 6 mm.
Claim 15
Dependent Claim
18 words
The method of claim 9 , wherein said prosthesis has a diameter of between 6 to 12 mm.
Claim 16
Dependent Claim
17 words
The method of claim 9 , wherein said prosthesis has a diameter of greater than 12 mm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-12-31 | 2005-07-02 | 2006-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-12-31 | 2009-07-02 | 2010-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-12-31 | 2013-07-02 | 2014-01-01 | $7700.00 | Window Closed / Lapsed |