US5588962A — Drug treatment of diseased sites deep within the …

Claim 1

Independent Claim 163 words

A method for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: (a) providing a drug-localizing agent for a drug that is effective to treat said diseased site, (b) providing a medical device capable of being placed into said vascular lumen at said diseased site and capable of delivering said localizing agent locally at said site, (c) preparing said medical device for delivering said agent at said site, (d) placing said medical device at said site, (e) locally delivering said agent to said site in a manner that said agent is retained at said site, (f) removing said medical device from said vascular lumen, (g) providing said drug effective to treat said diseased site in a form suitable for systemic administration, and (h) systematically administering said drug so that said drug is transported through the body of said patient and localized at said diseased site by the presence of said drug-localizing agent retained at said site.

Claim 2

Independent Claim 163 words

A method for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: (a) providing a drug-localizing agent for a drug that is effective to treat said diseased site, (b) providing a medical device capable of being placed into said vascular lumen at said diseased site and capable of delivering said localizing agent locally at said site, (c) preparing said medical device for delivering said agent at said site, (d) placing said medical device at said site, (e) locally delivering said agent to said site in a manner that said agent is retained at said site, (f) removing said medical device from said vascular lumen, (g) providing said drug effective to treat said diseased site in a form suitable for systemic administration, and (h) systematically administering said drug so that said drug is transported through the body of said patient and localized at said diseased site by the presence of said drug-localizing agent retained at said site.

Claim 3

Dependent Claim 29 words

The method of claim 1 wherein said agent includes an adhesive polymer that adheres to said site, said polymer incorporating a specie that forms a complex with said drug.

Claim 4

Dependent Claim 14 words

The method of claim 1 comprising: delivering said agent to said site under pressure.

Claim 5

Dependent Claim 17 words

The method of claim 1 comprising: delivering said agent to said site with the aid of heat.

Claim 6

Dependent Claim 33 words

The method of claim 1, comprising: monitoring said patient for symptoms of restenosis after removing the medical device from the vascular lumen, and providing and administering said drug after observation of said symptoms.

Claim 7

Dependent Claim 47 words

The method of claim 1 comprising: locally delivering a sufficient amount of said agent to localize an effective amount of said drug from multiple sequential systemic administrations, and systematically administering a sufficient quantity of said drug to effectively treat said site in a sequential fashion as needed.

Claim 8

Dependent Claim 28 words

The method of claim 1 comprising: after systemically delivering a desired drug, delivering additional drug-localizing agent locally to said diseased site and, thereafter systemically delivering additional desired drug.

Claim 9

Dependent Claim 24 words

The method of claim 1 comprising: delivering a mixture of drug-localizing agents effective to concentrate different drugs and systemically administering said drugs as desired.

Claim 10

Dependent Claim 17 words

The method of claim 1 wherein said medical device is a dilatation catheter having an expandable portion.

Claim 11

Dependent Claim 42 words

The method of claim 1 comprising: providing a medical device in the form of a dilation catheter having an expandable portion, expanding said expandable portion to dilate said diseased site, and delivering said agent simultaneously with the dilation of said diseased site.

Claim 12

Dependent Claim 17 words

The method of claim 10 comprising: locally administering the same drug that is to be administered systemically.

Claim 13

Independent Claim 23 words

The method of any one of claims 1, 10, or 11 wherein said expandable portion includes a polymer capable of releasing said agent.

Claim 14

Dependent Claim 19 words

The method of claim 12 when said polymer is a compressible hydrogel capable of releasing said agent when compressed.

Claim 15

Dependent Claim 28 words

The method of claim 12 wherein said expandable portion includes openings or pores or channels through which said agent may pass to deliver said agent to said site.

Claim 16

Dependent Claim 15 words

The method of claim 1 said drug forms a chemical complex with said drug-localizing agent.

Claim 17

Dependent Claim 27 words

The method of claim 15 wherein said drug is an anionic species and said agent is a cationic species in the body lumen environment of said site.

Claim 18

Dependent Claim 15 words

The method of claim 15 wherein said agent is cimetidine and said drug is lidocaine.

Claim 19

Dependent Claim 10 words

The method of claim 15 wherein said drug is heparin.

Claim 20

Dependent Claim 12 words

The method of claim 18 wherein said agent is an ammonium cation.

Claim 21

Dependent Claim 11 words

The method of claim 19 wherein said agent is benzalkonium cation.

Claim 22

Independent Claim 141 words

A method for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: (a) providing a drug-localizing agent for a drug that is effective to treat said diseased site, (b) providing a medical device capable of being placed into said vascular lumen at said diseased site and capable of delivering said localizing agent locally at said site, (c) preparing said medical device for delivering said agent at said site, (d) placing said medical device at said site, (e) locally delivering said agent to said site in a manner that said agent is retained at said site, (f) removing said medical device from said vascular lumen, (g) monitoring said patient for symptoms of restenosis after removing the medical device from the vascular lumen, and (h) systemically administering said drug to said patient having symptoms of restenosis.

Claim 23

Independent Claim 141 words

A method for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: (a) providing a drug-localizing agent for a drug that is effective to treat said diseased site, (b) providing a medical device capable of being placed into said vascular lumen at said diseased site and capable of delivering said localizing agent locally at said site, (c) preparing said medical device for delivering said agent at said site, (d) placing said medical device at said site, (e) locally delivering said agent to said site in a manner that said agent is retained at said site, (f) removing said medical device from said vascular lumen, (g) monitoring said patient for symptoms of restenosis after removing the medical device from the vascular lumen, and (h) systemically administering said drug to said patient having symptoms of restenosis.

Claim 24

Independent Claim 74 words

A method for treating a diseased site deep within the body, comprising: locally delivering to said diseased site a drug-localizing agent using a medical device capable of carrying said agent to and releasing said agent at said site in a manner that the agent is retained at the site, removing the medical device from the body, and systemically delivering drug, said drug being localized at said site by the presence of said localizing agent.

Claim 25

Independent Claim 74 words

A method for treating a diseased site deep within the body, comprising: locally delivering to said diseased site a drug-localizing agent using a medical device capable of carrying said agent to and releasing said agent at said site in a manner that the agent is retained at the site, removing the medical device from the body, and systemically delivering drug, said drug being localized at said site by the presence of said localizing agent.

Claim 26

Dependent Claim 101 words

A kit for delivering a drug-localizing agent to a diseased site in a vascular lumen deep within the body of a patient, comprising: a drug-localizing agent, in a form suitable for local administration that is retained at said site and is effective for localizing a systemically-administered drug to said site, said agent lacking said drug in a form suitable for local administration, and a medical catheter device sized and constructed for placement into said vascular lumen at said diseased site and for delivering said localizing agent locally at said site in a manner that said agent is retained at said site.

Claim 27

Dependent Claim 101 words

A kit for delivering a drug-localizing agent to a diseased site in a vascular lumen deep within the body of a patient, comprising: a drug-localizing agent, in a form suitable for local administration that is retained at said site and is effective for localizing a systemically-administered drug to said site, said agent lacking said drug in a form suitable for local administration, and a medical catheter device sized and constructed for placement into said vascular lumen at said diseased site and for delivering said localizing agent locally at said site in a manner that said agent is retained at said site.

Claim 28

Dependent Claim 124 words

A kit for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: a drug-localizing agent in a form suitable for local administration that is retained at said site and is effective for localizing a systemically-administered drug, said agent lacking said drug in a form suitable for local administration, a drug, in a form suitable for systemic administration, that is effective to treat said diseased site and is localized at said site by prior administration of said localizing agent, and a medical catheter device sized and constructed for placement into said vascular lumen at said diseased site and for delivering said localizing agent locally at said site in a manner that said agent is retained at said site.

Claim 29

Dependent Claim 124 words

A kit for treating a diseased site in a vascular lumen deep within the body of a patient, comprising: a drug-localizing agent in a form suitable for local administration that is retained at said site and is effective for localizing a systemically-administered drug, said agent lacking said drug in a form suitable for local administration, a drug, in a form suitable for systemic administration, that is effective to treat said diseased site and is localized at said site by prior administration of said localizing agent, and a medical catheter device sized and constructed for placement into said vascular lumen at said diseased site and for delivering said localizing agent locally at said site in a manner that said agent is retained at said site.

Claim 30

Dependent Claim 19 words

The method of claim 23 or 24 wherein said medical device is a dilation catheter having an expandable portion.

Claim 31

Dependent Claim 18 words

The method of claim 25 wherein said expandable portion includes a polymer membrane capable of releasing said agent.

Claim 32

Dependent Claim 19 words

The method of claim 26 when said polymer is a compressible hydrogel capable of releasing said agent when compressed.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1999-12-31	2000-07-01	2000-12-31	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2003-12-31	2004-07-01	2004-12-31	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2007-12-31	2008-07-01	2008-12-31	$7700.00	Window Closed / Lapsed

Drug treatment of diseased sites deep within the body

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