US5356433A — Biocompatible metal surfaces

Claim 1

Independent Claim 175 words

A medical device having a biocompatible surface, the biocompatible surface having been made by a process comprising the steps of: providing a metallic member having a tantalum oxide-containing surface thereof, said metallic member being flexible and being sized and shaped as a stent; treating the tantalum oxide containing surface with an amino-terminated organosilane having amine reactive sites and covalently linking the organosilane with the flexible metallic member to effect a condensation reaction that covalently links the tantalum oxide and silicon moieties of the organosilane in order to form a flexible organosilane-coated tantalum stent; applying a biologically active agent compostion to the organosilane-coated tantalum stent and forming a covalent linkage between the organosilane and the biologically active agent to provide a coated flexible tantalum stent; and the coated flexible tantalum stent thus formed has a coating which withstands cracking upon flexure, and the tantalum stent thus formed is a biocompatible tantalum stent which, when implanted within a living body, prevents substantial thrombus from occurring on its surface while not significantly interfering with endothelialization of said surface.

Claim 2

Dependent Claim 175 words

A medical device having a biocompatible surface, the biocompatible surface having been made by a process comprising the steps of: providing a metallic member having a tantalum oxide-containing surface thereof, said metallic member being flexible and being sized and shaped as a stent; treating the tantalum oxide containing surface with an amino-terminated organosilane having amine reactive sites and covalently linking the organosilane with the flexible metallic member to effect a condensation reaction that covalently links the tantalum oxide and silicon moieties of the organosilane in order to form a flexible organosilane-coated tantalum stent; applying a biologically active agent compostion to the organosilane-coated tantalum stent and forming a covalent linkage between the organosilane and the biologically active agent to provide a coated flexible tantalum stent; and the coated flexible tantalum stent thus formed has a coating which withstands cracking upon flexure, and the tantalum stent thus formed is a biocompatible tantalum stent which, when implanted within a living body, prevents substantial thrombus from occurring on its surface while not significantly interfering with endothelialization of said surface.

Claim 3

Dependent Claim 36 words

The medical device in accordance with claim 1, wherein the covalent linkage of the applying and forming step is between the amine moiety of the amino-terminated organosilane and a carboxyl moiety of the biologically active agent.

Claim 4

Dependent Claim 56 words

The medical device in accordance with claim 1, wherein said step of treating and covalently linking includes dipping the metallic member into an organosilane of the formula NH 2 --R--Si--(OR') n , wherein R is a short chain length aliphatic group, R' is selected from the group consisting of methyl and ethyl, and n is 3.

Claim 5

Dependent Claim 27 words

The medical device in accordance with claim 1, further including curing the organosilane-coated metallic member at an elevated temperature prior to said step of applying and forming.

Claim 6

Dependent Claim 18 words

The medical device in accordance with claim 1, wherein said flexible metallic member has a generally helical configuration.

Claim 7

Dependent Claim 20 words

The medical device in accordance with claim 1, wherein said flexible metallic member is a generally helically wound tantalum stent.

Claim 8

Dependent Claim 150 words

A medical device having a biocompatible anti-thrombogenic tantalum surface, comprising: a metallic member for a medical device, the metallic member having a tantalum oxide surface and being flexible and being sized and shaped as a stent, the metallic member having a biologically active surface treatment covalently adhered to the tantalum oxide surface; said biologically active surface treatment including an organosilane component having amine reactive sites, the organosilane component having silicon moieties covalently linked to tantalum oxide moieties of the metallic member, said biologically active surface treatment further including a biologically active agent covalently bound to the organosilane component to define a biocompatible tantalum stent; and said biocompatible tantalum stent has a surface which substantially prevents thrombus formation thereonto while avoiding any significant interference of the development of endothelialization of the biocompatible tantalum stent, and said biocompatible tantalum stent has a coating which is flexible and which withstands cracking upon flexure.

Claim 9

Dependent Claim 150 words

A medical device having a biocompatible anti-thrombogenic tantalum surface, comprising: a metallic member for a medical device, the metallic member having a tantalum oxide surface and being flexible and being sized and shaped as a stent, the metallic member having a biologically active surface treatment covalently adhered to the tantalum oxide surface; said biologically active surface treatment including an organosilane component having amine reactive sites, the organosilane component having silicon moieties covalently linked to tantalum oxide moieties of the metallic member, said biologically active surface treatment further including a biologically active agent covalently bound to the organosilane component to define a biocompatible tantalum stent; and said biocompatible tantalum stent has a surface which substantially prevents thrombus formation thereonto while avoiding any significant interference of the development of endothelialization of the biocompatible tantalum stent, and said biocompatible tantalum stent has a coating which is flexible and which withstands cracking upon flexure.

Claim 10

Dependent Claim 18 words

The medical device in accordance with claim 7, wherein said flexible metallic member has a generally helical configuration.

Claim 11

Dependent Claim 19 words

The medical device in accordance with claim 7, wherein the metallic member is a generally helically wound tantalum stent.

Claim 12

Dependent Claim 60 words

The medical device in accordance with claim 9, wherein said organosilane component is of the formula NH 2 --R--Si(OR') 3 , wherein R is a short chain length aliphatic group and R' is selected from the group consisting of methyl and ethyl, and said biologically active agent is selected from the group consisting of a mucopolysaccharide and a glucose amine.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1997-10-17	1998-04-18	1998-10-18	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2001-10-17	2002-04-18	2002-10-18	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2005-10-17	2006-04-18	2006-10-18	$7700.00	Window Closed / Lapsed

Biocompatible metal surfaces

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