Patent US2536750A successfully refreshed from Google Patents.
US4876126A
Expired / Lapsed
US
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Medical instrument and method for making
Assignee: Terumo Corp
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Filing: 1988-09-01
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Granted: 1989-10-24
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Expires: 2008-09-01
Abstract
Abstract A medical instrument comprises a substrate which has at least on its surface a reactive functional group covalently bonded with a water-soluble polymer or derivative thereof, whereby said surface has lubricity when wetted. The water-soluble polymer is a cellulosic polymer, maleic anhydride polymer, polyacrylamide or water-soluble nylon. The medical instrument is prepared by treating a substrate with a solution of a compound having a reactive functional group to form an undercoat so that the reactive functional group is present at least on the substrate surface, and then treating the substrate with a water-soluble polymer or derivative thereof to covalently bond the reactive functional group with the water-soluble polymer to thereby form a coat of the water-soluble polymer on the undercoat and optionally, contacting the treated substrate with water.
Inventors
- 👤 Naoto Takemura
- 👤 Susumu Tanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:32
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/1379; Y10T428/139; Y10T428/1393; Y10T428/31504; Y10T428/31511; Y10T428/31551; Y10T428/31573; Y10T428/31725; Y10T428/31855; Y10T428/3188
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
63 words
A medical instrument comprising: a substrate inherently having a reactive functional group on a surface thereof; a water soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water soluble nylon, or a derivative thereof, said water soluble polymer being covalently bonded with said reactive functional group, said surface exhibiting lubricity when wetted with aqueous fluid.
Claim 2
Dependent Claim
63 words
A medical instrument comprising: a substrate inherently having a reactive functional group on a surface thereof; a water soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water soluble nylon, or a derivative thereof, said water soluble polymer being covalently bonded with said reactive functional group, said surface exhibiting lubricity when wetted with aqueous fluid.
Claim 3
Dependent Claim
15 words
A medical instrument as claimed in claim 1 wherein said cellulosic polymer is hydroxypropyl cellulose.
Claim 4
Dependent Claim
23 words
A medical instrument as claimed in claim 1 wherein said maleic anhydride polymer is a copolymer of methyl vinyl ether and maleic anhydride.
Claim 5
Dependent Claim
26 words
A medical instrument as claimed in claim 1 wherein said reactive functional group is selected from the class consisting of aldehyde, epoxy, isocyanate, and amino groups.
Claim 6
Dependent Claim
40 words
A medical instrument as claimed in claim 1 wherein said medical instrument is a guide member formed of a wire member insertable through a medical tubing for enabling said medical tubing to be moved into and out of a body.
Claim 7
Dependent Claim
21 words
A medical instrument as claimed in claim 1, wherein said water-soluble polymer has an average molecular weight of 30,000 to 5,000,000.
Claim 8
Independent Claim
110 words
A method for preparing a medical instrument comprising: treating a substrate constituting said medical instrument, said substrate having a surface, with a solution of a compound having a reactive functional group to form an undercoat so that said reactive functional group is present at least on said surface of said substrate; and treating said substrate with a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water-soluble nylon, or a derivative thereof, to covalently bond said reactive functional group with said water-soluble polymer to form a coat of said water-soluble polymer on said undercoat so that said surface has lubricity when wetted.
Claim 9
Independent Claim
110 words
A method for preparing a medical instrument comprising: treating a substrate constituting said medical instrument, said substrate having a surface, with a solution of a compound having a reactive functional group to form an undercoat so that said reactive functional group is present at least on said surface of said substrate; and treating said substrate with a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water-soluble nylon, or a derivative thereof, to covalently bond said reactive functional group with said water-soluble polymer to form a coat of said water-soluble polymer on said undercoat so that said surface has lubricity when wetted.
Claim 10
Dependent Claim
19 words
A method for preparing a medical instrument as claimed in claim 7 wherein said cellulosic polymer is hydroxypropyl cellulose.
Claim 11
Dependent Claim
27 words
A method for, preparing a medical instrument as claimed in claim 7 wherein said maleic anhydride polymer is a copolymer of methyl vinyl ether and maleic anhydride.
Claim 12
Dependent Claim
30 words
A method for preparing a medical instrument as claimed in claim 7 wherein said reactive functional group is selected from the class consisting of aldehyde, epoxy, isocyanate, and amino groups.
Claim 13
Dependent Claim
44 words
A method for preparing a medical instrument as claimed in claim 7 wherein said medical instrument is a guide member formed of a wire member insertable through a medical tubing for enabling said medical tubing to be moved into and out of a body.
Claim 14
Dependent Claim
21 words
A method for preparing a medical instrument as claimed in claim 7, which further comprises contacting the treated substrate with water.
Claim 15
Dependent Claim
25 words
A method for preparing a medical instrument as claimed in claim 7 wherein said water-soluble polymer has an average molecular weight of 30,000 to 5,000,000.
Claim 16
Dependent Claim
75 words
A medical instrument comprising: a substantially reactive functional group-free substrate having a surface; an undercoat formed on said surface from a compound having a reactive functional group; a coating of a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water soluble nylon, or a derivative thereof, said water-soluble polymer being covalently bonded with said reactive functional group, said surface exhibiting lubricity when wetted with aqueous fluid.
Claim 17
Dependent Claim
75 words
A medical instrument comprising: a substantially reactive functional group-free substrate having a surface; an undercoat formed on said surface from a compound having a reactive functional group; a coating of a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water soluble nylon, or a derivative thereof, said water-soluble polymer being covalently bonded with said reactive functional group, said surface exhibiting lubricity when wetted with aqueous fluid.
Claim 18
Dependent Claim
15 words
A medical instrument as claimed in claim 14 wherein said cellulosic polymer is hydroxypropyl cellulose.
Claim 19
Dependent Claim
23 words
A medical instrument as claimed in claim 14 wherein said maleic anhydride polymer is a copolymer of methyl vinyl ether and maleic anhydride.
Claim 20
Dependent Claim
26 words
A medical instrument as claimed in claim 14 wherein said reactive functional group is selected from the class consisting of aldehyde, epoxy, isocyanate, and amino groups.
Claim 21
Dependent Claim
40 words
A medical instrument as claimed in claim 14 wherein said medical instrument is a guide member formed of a wire member insertable through a medical tubing for enabling said medical tubing to be moved into and out of a body.
Claim 22
Dependent Claim
21 words
A medical instrument as claimed in claim 14 wherein said water-soluble polymer has an average molecular weight of 30,000 to 5,000,000.
Claim 23
Dependent Claim
40 words
A medical instrument as claimed in claim 14 wherein said medical instrument is a guided member formed of a wire member insertable through a medical tubing for enabling said medical tubing to be moved into and out of a body.
Claim 24
Dependent Claim
21 words
A method for preparing a medical instrument as claimed in claim 14, which further comprises contacting the treated substrate with water.
Claim 25
Independent Claim
87 words
A method for preparing a medical instrument comprising: forming a surface of said medical instrument with a substrate inherently having a reactive functional group on a surface thereof; and treating said substrate with a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water-soluble nylon, or a derivative thereof, to covalently bond said reactive functional group with said water-soluble polymer to form a coat of said water-soluble polymer on said surface so that said surface exhibits lubricity when wetted.
Claim 26
Independent Claim
87 words
A method for preparing a medical instrument comprising: forming a surface of said medical instrument with a substrate inherently having a reactive functional group on a surface thereof; and treating said substrate with a water-soluble polymer selected from the class consisting of a cellulosic polymer, a maleic anhydride polymer, and a water-soluble nylon, or a derivative thereof, to covalently bond said reactive functional group with said water-soluble polymer to form a coat of said water-soluble polymer on said surface so that said surface exhibits lubricity when wetted.
Claim 27
Dependent Claim
19 words
A method for preparing a medical instrument as claimed in claim 22 wherein said cellulosic polymer is hydroxypropyl cellulose.
Claim 28
Dependent Claim
27 words
A method for preparing a medical instrument as claimed in claim 22 wherein said maleic anhydride polymer is a copolymer of methyl vinyl ether and maleic anhydride.
Claim 29
Dependent Claim
30 words
A method for preparing a medical instrument as claimed in claim 22 wherein said reactive functional group is selected from the class consisting of aldehyde epoxy, isocyanate, and amino groups.
Claim 30
Dependent Claim
25 words
A method for preparing a medical instrument as claimed in claim 22 wherein said water-soluble polymer has a average molecular weight of 30,000 to 5,000,000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-23 | 1993-04-24 | 1993-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-23 | 1997-04-24 | 1997-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-23 | 2001-04-24 | 2001-10-24 | $7700.00 | Window Closed / Lapsed |