Antimicrobial compositions

Claim 2

An antimicrobial composition comprising: 30 to 85 percent by weight of a binder consisting essentially of a material selected from the group consisting of acrylonitrile-butadiene-styrene copolymers, polyvinyl chloride, mixtures thereof, polyesters polyurethanes, styrene-block copolymers, natural and synthetic rubbers, polycarbonates, nylon and silicone rubber; and 15 to 70 percent by weight of an antimicrobial agent selected from the group consisting of compounds of antimicrobial metals and mixtures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 3

The antimicrobial composition of claim 1 in which said mixtures of acrylonitrile-butadiene-styrene copolymers and polyvinyl chloride consist of 25 to 75 percent by weight of acrylonitrile-butadiene-styrene copolymers and 25 to 75 percent by weight of polyvinyl chloride.

Claim 4

The antimicrobial composition of claim 1 in which said antimicrobial agent is selected from the group consisting of oxides and salts of silver and gold.

Claim 5

The antimicrobial composition of claim 1 in which said antimicrobial agent is selected from the group consisting of silver compounds.

Claim 6

The antimicrobial composition of claim 4 in which said antimicrobial agent is silver oxide.

Claim 7

The antimicrobial composition of claim 5 wherein said zone of inhibition forms, in 24 hours, a solution of at least 10 -6 molar concentration of silver ion concentration in a stagnant film of urine in contact with said surface.

Claim 8

An antimicrobial composition for coating articles comprising: 30 to 85 percent by weight of a binder; 15 to 70 percent by weight of an antimicrobial agent selected from the group consisting essentially of silver compounds, silver oxides and mixtures thereof, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 9

An antimicrobial composition for coating articles comprising: 30 to 85 percent by weight of a binder; 15 to 70 percent by weight of an antimicrobial agent selected from the group consisting essentially of silver compounds, silver oxides and mixtures thereof, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 10

The antimicrobial composition for coating articles of claim 7 wherein said binder consists essentially of acrylonitrile-butadiene-styrene copolymers.

Claim 11

The antimicrobial composition for coating articles of claim 7 wherein said binder consists essentially of a mixture of 35 to 65 percent by weight of acrylonitrile-butadiene-styrene copolymers and 35 to 65 percent by weight of polyvinyl chloride.

Claim 12

The antimicrobial composition for coating articles of claim 9 wherein said zone of inhibition forms, in 24 hours, a solution of at least 10 -6 molar concentration of silver ion concentration in a stagnant film of urine in contact with said surface.

Claim 13

A catheter adapter for use in indwelling urethral catheterization including an antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and selected from a group consisting essentially of acrylonitrile-butadiene-styrene copolymers, polyvinyl chloride, polyesters, polyurethanes of mixtures thereof; said antimicrobial metal compound being 0.15-70% by weight o the coating selected from the group consisting of compounds of antimicrobial metals and mixtures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 14

A catheter adapter for use in indwelling urethral catheterization including an antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and selected from a group consisting essentially of acrylonitrile-butadiene-styrene copolymers, polyvinyl chloride, polyesters, polyurethanes of mixtures thereof; said antimicrobial metal compound being 0.15-70% by weight o the coating selected from the group consisting of compounds of antimicrobial metals and mixtures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 15

The catheter adapter of claim 11 wherein said binder is of a high dielectric constant to provide discreetly dissolved particles on the surface to provide an initial high dose of antimicrobial metal compound.

Claim 16

The catheter adapter of claim 12 wherein said antimicrobial metal compound is of large particle size and is discreetly dissolved in the surface of the binder; and, said antimicrobial composition is selected from the group consisting of oxides and salts of silver and gold.

Claim 17

The catheter adapter of claim 13 wherein said antimicrobial composition forms a zone of inhibition which prevents and kills bacteria growth thereabout.

Claim 18

A silicone rubber foley catheter for use in indwelling urethral catherterization including an antimicrobial coating thereon; said antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and selected from a group consisting essentially of alkoxy curing RTV rubber, acidtoxy cured RTV silicone rubber, rubber latexes, and mistures thereof; said antimicrobial metal compound being 0.15-70 by weight of the coating selected from the group consisting of compounds of antimicrobial metals and mixtures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 19

A silicone rubber foley catheter for use in indwelling urethral catherterization including an antimicrobial coating thereon; said antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and selected from a group consisting essentially of alkoxy curing RTV rubber, acidtoxy cured RTV silicone rubber, rubber latexes, and mistures thereof; said antimicrobial metal compound being 0.15-70 by weight of the coating selected from the group consisting of compounds of antimicrobial metals and mixtures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 20

The silicone rubber foley catheter of claim 7 wherein said antimicrobial metal compound is of small particle size completely dissolved throughout the binder to provide and maintain a desired zone of inhibition in a stagnant film of urine in contact with said catheter for the longest possible period of time.

Claim 21

The silicone rubber foley catheter of claim 16 wherein said binder is 95% by weight alkoxy curing RTV rubber and said antimicrobial metal is 5% by weight silver sulfadiazine.

Claim 22

The silicone rubber foley catheter of claim 17 wherein said binder is 95-99% by weight alkoxy curing RTV rubber and said antimicrobial metal is 1-5% by weight of silver oxide, forming a smooth, adherent, strong antimicrobial coating capable of being stretched fifty (50) percent and further providing safe effective and long lasting zones of inhibition.

Claim 23

A flexible polyvinyl chloride catheter for use in short term indwelling urethral catherterization including an antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and being of a high dielectric constant; and said antimicrobial metal compound being 0.15-70% by weight of the coating and being of small particle size and selected from the group consisting of compounds of antimicrobial metals and mistures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.

Claim 24

A flexible polyvinyl chloride catheter for use in short term indwelling urethral catherterization including an antimicrobial coating thereon; said antimicrobial coating comprising a binder and an antimicrobial metal compound; said binder being from 30-99.85% by weight of the coating and being of a high dielectric constant; and said antimicrobial metal compound being 0.15-70% by weight of the coating and being of small particle size and selected from the group consisting of compounds of antimicrobial metals and mistures thereof that are physiologically compatible with human tissue, said binder having a sufficiently low dielectric constant so as to allow said antimicrobial agent to form a chain-like structure to create an initial dose of antimicrobial action upon first use by allowing antimicrobial ions on a surface of said composition to dissolve, said chain-like structure providing a pathway in said binder to allow interior antimicrobial ions in said composition to come to said surface of said composition to provide subsequent doses of antimicrobial action.