US5295944A
Expired / Lapsed
US
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Method for treating a tumor with ionizing radiation
Assignee: Dana Farber Cancer Institute Inc
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Filing: 1991-05-14
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Granted: 1994-03-22
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Expires: 2011-05-14
Abstract
Abstract A method is disclosed treating a tumor in a host by administering an ultrapurified polymerized hemoglobin solution to the host and thereafter administering ionizing radiation, such as X-rays, to the tumor. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.
Inventors
- 👤 Beverly A. Teicher
- 👤 Carl W. Rausch
- 👤 2nd Robert E. Hopkins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:50
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/41; A61K38/42; A61K2121/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
49 words
A method for treating a tumor in a host with ionizing radiation, comprising: a) administering to said host an ultrapurified polymerized hemoglobin solution in an amount sufficient to increase the antitumor effect of said ionizing radiation; and, b) administering to said tumor an effective amount of said ionizing radiation.
Claim 2
Independent Claim
49 words
A method for treating a tumor in a host with ionizing radiation, comprising: a) administering to said host an ultrapurified polymerized hemoglobin solution in an amount sufficient to increase the antitumor effect of said ionizing radiation; and, b) administering to said tumor an effective amount of said ionizing radiation.
Claim 3
Dependent Claim
18 words
A method of claim 1 wherein said ionizing radiation comprises X-rays, gamma rays, electrons or high LET radiation.
Claim 4
Dependent Claim
24 words
A method of claim 1 wherein said ultrapurified polymerized hemoglobin solution comprises a hemoglobin which is dependent upon chloride ion concentration for oxygen transport.
Claim 5
Dependent Claim
14 words
A method of claim 1 wherein said ultrapurified polymerized hemoglobin solution is bovine hemoglobin.
Claim 6
Dependent Claim
18 words
A method of claim 4 wherein said ionizing radiation comprises X-rays, gamma rays, electrons or high LET radiation.
Claim 7
Dependent Claim
11 words
A method of claim 1 wherein said host is a mammal.
Claim 8
Dependent Claim
13 words
A method of claim 6 wherein said mammalian host is a human being.
Claim 9
Dependent Claim
47 words
In a method of treating a tumor in a mammalian host with ionizing radiation the improvement comprising: administering to said mammalian host, prior to treatment with said ionizing radiation, an ultrapurified bovine hemoglobin solution in an amount sufficient to increase the antitumor effect of said ionizing radiation.
Claim 10
Dependent Claim
47 words
In a method of treating a tumor in a mammalian host with ionizing radiation the improvement comprising: administering to said mammalian host, prior to treatment with said ionizing radiation, an ultrapurified bovine hemoglobin solution in an amount sufficient to increase the antitumor effect of said ionizing radiation.
Claim 11
Dependent Claim
13 words
The improvement of claim 8 wherein said mammalian host comprises a human being.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-21 | 1997-09-20 | 1998-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-21 | 2001-09-20 | 2002-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-21 | 2005-09-20 | 2006-03-22 | $7700.00 | Window Closed / Lapsed |