US5447966A Expired / Lapsed US ⏱️ 0.0 years remaining

Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin

Assignee: United States Surgical Corp

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Filing: 1994-02-08

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Granted: 1995-09-05

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Expires: 2014-02-08

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Abstract

Abstract An absorbable composition useful for treating absorbable surgical devices to render the same storage stable and/or to enhance delivery of the article and/or a medico-surgically useful substance to a wound. The preferred composition includes collagen or a derivative thereof, a plasticizer and a surfactant.

Inventors

👤 Matthew E. Hermes
👤 Ross R. Muth
👤 Darel L. Gustafson

Bibliographic Details

Application Number —

Jurisdiction US

Data Source google_patents

Last Synchronized 2026-10-23 09:37

CPC Classifications

A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A01; A01N; A01N37/00; A01N37/36; A61B; A61B17/00; A61B17/04; A61B17/06; A61B17/06114; A61B17/06166; A61L17/00; A61L17/14; A61L17/145; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/58; A61L31/08; A61L31/10; A61B17/064; A61B17/08; A61B17/083; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61B2017/00004; A61B2017/0647; A61B2017/0648; A61B50/00; A61B50/30; A61F; A61F13/00; A61F2/00; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2210/00; A61F2210/0004

Claims Analysis

Total Claims: 14

Claim 1

Independent Claim 134 words

A storage stable, bioabsorbable surgical device possessing improved storage stability and formed from a molded bioabsorbable article coated with a bioabsorbable composition, the composition comprising: (i) about 98% to about 60% by weight gelatin; (ii) about 1% to about 30% by weight of a plasticiser dispersed or dissolved in (i) said gelatin, wherein said plasticizer is a water-soluble hygroscopic polyhydroxy compound or ester derivative thereof; and (iii) about 0.1% to about 25% by weight of a polyethylene oxide-polypropylene oxide block copolymer surfactant dispersed or dissolved in (i) said gelatin or in (ii) said plasticizer; wherein said surgical device is a surgical clip, stable, pin, screw, or tac fabricated in whole or in part from a polymer or copolymer of gylcolic acid, lactic acid, glycolide, lactide, dioxanone, trimethylene carbonate, caprolactone, polyalkylene glycol or combination thereof.

Claim 2

Dependent Claim 134 words

Claim 3

Dependent Claim 38 words

The device of claim 1 wherein said polyhydroxy compound or ester derivative thereof is selected from the group consisting of glycerol, monacetin, diacetin, ethylene glycol, diethylene glycol, triethylene glycol, 1,3-propanediol, trimethylolethane, trimethylol propane, pentaerythritol, sorbitol and mixtures thereof.

Claim 4

Dependent Claim 11 words

The device of claim 2 wherein said polyhydroxy compound is glycerol.

Claim 5

Dependent Claim 63 words

The device of claim 1 wherein (ii) said polyethylene oxide-polypropylene oxide block copolymer has the formula H(OCH.sub.2 CH.sub.2).sub.x (OC.sub.3 H.sub.6).sub.y (OCH.sub.2 CH.sub.2).sub.z OH wherein x is a number in the range from about 45 to about 90, y is a number in the range of from about 60 to about 85 and z is a number of from about 45 to about 90.

Claim 6

Dependent Claim 20 words

The device of claim 4 wherein said polyethylene oxide-polypropylene oxide block copolymer is H(OCH.sub.2 CH.sub.2).sub.75 (OC.sub.3 H.sub.6).sub.80 (OCH.sub.2 CH.sub.2).sub.50 OH.

Claim 7

Dependent Claim 43 words

The device of claim 5 wherein said compositioin comprises: (i) about 90% to about 70% by weight of said gelatin; (ii) about 5% to about 25% by weight of said plasticizer; and (iii) about 1% to about 20% by weight of said surfactant.

Claim 8

Dependent Claim 43 words

The device of claim 6 wherein said composition comprises: (i) about 85% to about 75% by weight of said gelatin; (ii) about 10% to about 15% by weight of said plasticizer; and (iii) about 5% to about 15% by weight of said surfactant.

Claim 9

Dependent Claim 61 words

The device of claim 1 additionally comprising at least one additive selected from the group consisting of antimicrobial agent, Human Growth Factor, magainin, tissue or kidney plasminogen activator to cause thrombosis, superoxide dismutase to scavenge tissue damaging free radicals, tumor necrosis factor for cancer therapy, colony stimulating factor, interferon, interleukin-2 or other lymphokine to enhance the immune system and mixtures thereof.

Claim 10

Dependent Claim 25 words

The device of claim 8 wherein said Human Growth Factor is selected from the group consisting of hEGF, TGF-beta, IGF, PDGF, FGF and mixtures thereof.

Claim 11

Dependent Claim 29 words

The device of claim 1 wherein said device is fabricated in whole or in part from a polymer or copolymer possessing short-chain polyester linkages or other readily hydrolyzable linkages.

Claim 12

Dependent Claim 12 words

The device of claim 1 wherein the plasticizer is water or glycerol.

Claim 13

Dependent Claim 69 words

The device of claim 1 wherein said plasticizer (ii) is glycerol; and said surfactant (iii) has the formula H(OCH.sub.2 CH.sub.2).sub.x (OC.sub.3 H.sub.6).sub.y (OCH.sub.2 CH.sub.2).sub.z OH wherein x is a number in the range of from about 45 to about 90, y is a number in the range of from about 60 to about 85 and z is a number in the range of from about 45 to about 90.

Claim 14

Dependent Claim 14 words

The surgical device of claim 1 wherein said device is a substantially rigid prothesis.

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USPTO Annuity & Maintenance Windows

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-09-04	1999-03-06	1999-09-05	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-09-04	2003-03-06	2003-09-05	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-09-04	2007-03-06	2007-09-05	$7700.00	Window Closed / Lapsed

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